Imputed gene expression based on common variants is instrumental to understanding the biology of psychiatric risk. By identifying trans-eQTLs via co-expression across different brain regions, we aimed to generate a platform for Transcriptome-Wide Association Studies with enhanced gene expression imputation, particularly for genes depleted for cis-eQTLs.
ENHANCING GENE EXPRESSION PREDICTION IN MAJOR PSYCHIATRIC DISORDERS VIA CO-EXPRESSION MODELS
Kikidis, Gianluca C.;Blasi, Giuseppe;Rampino, Antonio;Bellantuono, Loredana;Sportelli, Leonardo;Penzel, Nora;Pergola, Giulio
2023-01-01
Abstract
Imputed gene expression based on common variants is instrumental to understanding the biology of psychiatric risk. By identifying trans-eQTLs via co-expression across different brain regions, we aimed to generate a platform for Transcriptome-Wide Association Studies with enhanced gene expression imputation, particularly for genes depleted for cis-eQTLs.File in questo prodotto:
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