Compounds 8a–d have been designed as bioisosters of tariquidar for imaging P-gp expression and density by PET. The results displayed that compounds 8b and 8d could be considered potential P-gp/BCRP ligands suitable as 11C and 18F radiotracers, respectively.
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp
Contino, Marialessandra;Zinzi, Laura;Perrone, Maria Grazia;Leopoldo, Marcello;Berardi, Francesco;Perrone, Roberto;Colabufo, Nicola Antonio
2013-01-01
Abstract
Compounds 8a–d have been designed as bioisosters of tariquidar for imaging P-gp expression and density by PET. The results displayed that compounds 8b and 8d could be considered potential P-gp/BCRP ligands suitable as 11C and 18F radiotracers, respectively.File in questo prodotto:
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