IRIS
DE LUCA, Annamaria
 Distribuzione geografica
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Continente #
NA - Nord America 13.176
EU - Europa 2.829
AS - Asia 1.676
SA - Sud America 43
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 5
AF - Africa 4
Totale 17.741
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Nazione #
US - Stati Uniti d'America 13.137
CN - Cina 1.029
SE - Svezia 678
UA - Ucraina 488
SG - Singapore 487
IT - Italia 408
DE - Germania 344
FI - Finlandia 275
RU - Federazione Russa 248
GB - Regno Unito 179
FR - Francia 71
IN - India 56
BE - Belgio 45
CA - Canada 38
IE - Irlanda 38
BR - Brasile 34
VN - Vietnam 34
IR - Iran 22
CZ - Repubblica Ceca 19
HK - Hong Kong 16
NL - Olanda 14
JP - Giappone 11
AU - Australia 6
EU - Europa 5
KR - Corea 5
LT - Lituania 5
TR - Turchia 5
AT - Austria 3
CL - Cile 3
DK - Danimarca 3
RO - Romania 3
VE - Venezuela 3
EE - Estonia 2
EG - Egitto 2
ES - Italia 2
MA - Marocco 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
UZ - Uzbekistan 2
AE - Emirati Arabi Uniti 1
AR - Argentina 1
BD - Bangladesh 1
CH - Svizzera 1
EC - Ecuador 1
ID - Indonesia 1
IQ - Iraq 1
KG - Kirghizistan 1
LV - Lettonia 1
MX - Messico 1
MY - Malesia 1
PH - Filippine 1
PK - Pakistan 1
TH - Thailandia 1
UY - Uruguay 1
Totale 17.741
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Città #
Fairfield 1.625
Woodbridge 1.335
Chandler 1.251
Ashburn 1.173
Jacksonville 1.125
Houston 929
Cambridge 680
Seattle 634
Wilmington 568
Ann Arbor 550
Nyköping 519
Singapore 367
Lawrence 276
Roxbury 272
Nanjing 253
Des Moines 177
Princeton 173
Beijing 168
Boardman 165
Bari 134
New York 134
Inglewood 119
San Diego 97
Nanchang 78
Hebei 70
Jiaxing 62
Los Angeles 58
Shenyang 49
Brussels 44
Santa Clara 43
Tianjin 40
Dublin 37
London 37
Changsha 33
Dearborn 33
Dong Ket 33
Pune 31
Milan 30
Helsinki 28
San Mateo 26
Guangzhou 24
Shanghai 23
Falls Church 22
Leawood 21
Brooklyn 20
Ardabil 19
Redwood City 19
Taranto 19
Zhengzhou 19
Brno 18
Toronto 18
Augusta 17
Wuhan 17
Monmouth Junction 16
Hong Kong 15
Jinan 15
Hefei 14
Paris 14
Ningbo 13
Ottawa 13
Washington 13
Munich 11
San Francisco 11
Prescot 10
Kilburn 8
Kunming 8
Norwalk 8
Hounslow 7
Indiana 7
Tappahannock 7
Chicago 6
Jinhua 6
Rome 6
São Paulo 6
Camerino 5
Genova 5
Grafing 5
Sennori 5
Tokyo 5
Wuxi 5
Auburn Hills 4
Campobello Di Mazara 4
Genoa 4
Islington 4
Kansas City 4
Marseille 4
Modugno 4
Montignoso 4
Mumbai 4
Quanzhou 4
Simi Valley 4
Trani 4
Turin 4
Albairate 3
Chongqing 3
Clifton 3
Council Bluffs 3
Frankfurt am Main 3
Grottaglie 3
Kiev 3
Totale 14.029
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 414
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 142
Isolation and characterization of neural stem cells from dystrophic mdx mouse 141
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 136
Dasatinib/HP-β-CD inclusion complex based aqueous formulation as a promising tool for the treatment of paediatric neuromuscular disorders 134
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 129
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 126
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 124
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 121
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 118
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 116
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 110
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 110
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 108
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 108
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 106
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 106
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 106
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 104
Effetti di una nuova 1-4 diidropiridina, il Bay K 8644, su organi a muscolatura liscia isolati di cavia 102
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 102
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 102
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 101
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 101
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 100
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 98
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 98
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 97
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 96
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 96
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 96
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 95
Mechanisms of block of sodium channels in human myoballs by local anaesthetics with different use dependence 93
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 93
null 93
Taurine and skeletal muscle ion channels 91
null 91
First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant 91
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 90
null 90
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 90
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 90
Changes of chloride channel regulation in rat skeletal muscle during aging 89
Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy. 88
Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, the Netherlands 88
The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation 87
null 87
Excitation-contraction coupling of extensor digitorum longus muscle of dystrophic MDX mouse 86
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 86
Aging and chloride channel regulation in rat fast-twitch muscle fibres 85
Stakeholder cooperation to overcome challenges in orphan medicine development: The example of Duchenne muscular dystrophy 85
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 85
Prednisone in dystrophin-deficient Caernorabditis elegans 84
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 84
Muscle loading modulates aquaporin-4 expression in skeletal muscle 83
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 83
Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds 83
Skeletal Muscle Chloride Channel, a Biophysical Sensor of Dystrophic Progression in Mdx Mouse, is a Potential Target of Pro-inflammatory Mediators 82
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 82
Evaluation of potential synergistic action of a combined treatment with alpha-methyl-prednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy. 82
Drug screening for muscular dystrophy: From target to function toward patients, is anything lost? 81
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 81
A stereospecific binding site regulates the C1- ion channel in rat skeletal muscle 80
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 79
PHARMACOLOGICAL BLOCK OF CHLORIDE CHANNELS DURING DEVELOPMENT AFFECTS CONTRACTILE AND ELECTRICAL-PROPERTIES OF RAT SKELETAL-MUSCLE 78
null 78
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 77
Enantiomers of tocainide and mexiletine: antimyotonic activity and use-dependent block of skeletal muscle Na+ channels 77
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 77
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 77
null 76
null 75
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 75
Taurine and skeletal muscle disorders 75
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 75
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 75
Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse 74
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 74
Antimyotonic effects of enantiomers of mexiletine-like drugs 74
null 73
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 73
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 73
Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice. 72
Pharmacology of CLC chloride channels and transporters 72
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 72
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity 71
Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channels 71
Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation 71
Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline 71
Aberrant mechanical-metabolic coupling in muscular dystrophy: gene expression and functional studies in mdx mouse muscle in relation to age and exercise 71
Effects of chronic taurine treatment on the electrical and contractile properties of skeletal muscle fibers of aged rats 70
Dual effects of taurine on membrane ionic conductances of rat skeletal muscle fibers 70
null 70
null 70
Glial dystrophin-associated proteins, laminin and agrin, are downregulated in the brain of mdx mouse 69
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 69
Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy 69
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 69
227thENMC International Workshop:. Finalizing a plan to guarantee quality in translational research for neuromuscular diseases Heemskerk, Netherlands, 10-11 February 2017 69
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 68
Totale 9.225
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Categoria #
all - tutte 83.523
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 83.523
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.928 0 0 0 0 0 0 444 333 492 219 350 90
2020/20212.863 314 134 221 282 309 104 203 153 271 422 287 163
2021/20221.994 70 285 22 114 85 116 105 113 120 137 310 517
2022/20233.208 498 271 201 309 395 444 21 346 535 30 87 71
2023/20241.437 89 232 49 84 98 228 158 295 16 56 22 110
2024/20251.382 145 71 390 154 131 462 29 0 0 0 0 0
Totale 18.329