IRIS
DE LUCA, Annamaria
 Distribuzione geografica
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Continente #
NA - Nord America 17.497
AS - Asia 7.033
EU - Europa 4.567
SA - Sud America 1.870
AF - Africa 263
OC - Oceania 17
Continente sconosciuto - Info sul continente non disponibili 7
AN - Antartide 1
Totale 31.255
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Nazione #
US - Stati Uniti d'America 17.226
SG - Singapore 3.062
CN - Cina 1.563
BR - Brasile 1.510
HK - Hong Kong 891
IT - Italia 750
SE - Svezia 697
RU - Federazione Russa 555
DE - Germania 526
UA - Ucraina 516
FR - Francia 418
FI - Finlandia 412
VN - Vietnam 389
GB - Regno Unito 313
IN - India 233
BD - Bangladesh 186
CA - Canada 143
AR - Argentina 125
ID - Indonesia 107
IQ - Iraq 97
MX - Messico 76
TR - Turchia 73
NL - Olanda 63
JP - Giappone 60
ZA - Sudafrica 59
CI - Costa d'Avorio 52
CO - Colombia 51
EC - Ecuador 50
BE - Belgio 48
PK - Pakistan 46
IE - Irlanda 45
ES - Italia 44
PL - Polonia 42
SA - Arabia Saudita 39
CL - Cile 37
VE - Venezuela 37
MA - Marocco 36
UZ - Uzbekistan 34
IR - Iran 29
AT - Austria 25
EG - Egitto 24
AE - Emirati Arabi Uniti 22
PH - Filippine 22
KE - Kenya 21
MY - Malesia 21
CZ - Repubblica Ceca 20
JO - Giordania 19
TN - Tunisia 18
UY - Uruguay 18
DZ - Algeria 16
NP - Nepal 16
PE - Perù 16
PY - Paraguay 15
AU - Australia 14
LT - Lituania 14
IL - Israele 13
KR - Corea 13
KZ - Kazakistan 12
AZ - Azerbaigian 10
BO - Bolivia 10
ET - Etiopia 10
CR - Costa Rica 9
KG - Kirghizistan 9
RS - Serbia 9
TW - Taiwan 9
AL - Albania 8
HN - Honduras 8
OM - Oman 8
PS - Palestinian Territory 8
AO - Angola 6
CH - Svizzera 6
DK - Danimarca 6
GE - Georgia 6
GR - Grecia 6
HU - Ungheria 6
JM - Giamaica 6
LB - Libano 6
NI - Nicaragua 6
PA - Panama 6
RO - Romania 6
TH - Thailandia 6
TT - Trinidad e Tobago 6
EU - Europa 5
PT - Portogallo 5
EE - Estonia 4
KH - Cambogia 4
NG - Nigeria 4
SN - Senegal 4
BY - Bielorussia 3
HR - Croazia 3
LV - Lettonia 3
LY - Libia 3
ME - Montenegro 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
QA - Qatar 3
SK - Slovacchia (Repubblica Slovacca) 3
BH - Bahrain 2
CY - Cipro 2
DM - Dominica 2
Totale 31.214
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Città #
Ashburn 1.858
Singapore 1.668
Fairfield 1.626
Woodbridge 1.335
Chandler 1.245
Jacksonville 1.129
Houston 937
San Jose 930
Hong Kong 885
Cambridge 682
Seattle 644
Dallas 638
Wilmington 570
Ann Arbor 550
Nyköping 512
Beijing 397
Lawrence 274
Roxbury 272
Lauterbourg 266
Nanjing 255
New York 221
Los Angeles 214
Boardman 183
Des Moines 178
Princeton 171
Bari 170
Helsinki 138
Ho Chi Minh City 127
Council Bluffs 122
Inglewood 119
São Paulo 116
Santa Clara 105
San Diego 98
Hanoi 91
Nanchang 78
Hebei 70
Buffalo 69
Chicago 63
Jiaxing 62
Munich 62
Jakarta 61
London 56
Brooklyn 55
Abidjan 50
Shenyang 49
Baghdad 45
Brussels 45
Milan 45
Frankfurt am Main 44
Dublin 42
Rio de Janeiro 41
Tianjin 41
Tokyo 40
Bitetto 38
Brasília 36
Falkenstein 36
Pune 36
Changsha 35
Toronto 34
Chennai 33
Dearborn 33
Dong Ket 33
Nuremberg 33
Warsaw 33
Belo Horizonte 32
Tashkent 31
Bitonto 30
Montreal 30
Shanghai 30
The Dalles 30
Orem 29
Rome 29
San Francisco 29
Victoria 29
Mexico City 27
San Mateo 27
Columbus 26
Stockholm 26
Turku 26
Guangzhou 25
Moscow 25
Denver 24
Curitiba 22
Falls Church 22
Medellín 22
Atlanta 21
Johannesburg 21
Leawood 21
Paris 21
Phoenix 21
Taranto 21
Zhengzhou 21
Augusta 20
Campinas 20
Ardabil 19
Redwood City 19
Washington 19
Brno 18
Nairobi 18
Wuhan 18
Totale 20.993
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 459
Myasthenia Gravis Treatment: From Old Drugs to Innovative Therapies with a Glimpse into the Future 322
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 289
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 236
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 235
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 230
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 228
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 220
Isolation and characterization of neural stem cells from dystrophic mdx mouse 203
Dasatinib/HP-β-CD inclusion complex based aqueous formulation as a promising tool for the treatment of paediatric neuromuscular disorders 203
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 199
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 199
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 197
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 190
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 187
GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy 176
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 174
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 172
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 164
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 161
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 157
Aging and chloride channel regulation in rat fast-twitch muscle fibres 155
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 154
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 154
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 152
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 151
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 150
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 150
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 149
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 149
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 148
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 148
Aberrant mechanical-metabolic coupling in muscular dystrophy: gene expression and functional studies in mdx mouse muscle in relation to age and exercise 147
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 146
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 145
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 143
Alteration of stim1/orai1-mediated soce in skeletal muscle: Impact in genetic muscle diseases and beyond 142
Changes of chloride channel regulation in rat skeletal muscle during aging 141
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 139
Ultrasonography validation for early alteration of diaphragm echodensity and function in the mdx mouse model of Duchenne muscular dystrophy 139
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 138
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 137
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 137
Stakeholder cooperation to overcome challenges in orphan medicine development: The example of Duchenne muscular dystrophy 136
Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds 136
A stereospecific binding site regulates the C1- ion channel in rat skeletal muscle 135
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 134
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 134
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 133
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 133
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 133
227thENMC International Workshop:. Finalizing a plan to guarantee quality in translational research for neuromuscular diseases Heemskerk, Netherlands, 10-11 February 2017 133
Effetti di una nuova 1-4 diidropiridina, il Bay K 8644, su organi a muscolatura liscia isolati di cavia 132
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 132
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 131
"The Social Network" and Muscular Dystrophies: The Lesson Learnt about the Niche Environment as a Target for Therapeutic Strategies 130
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers 129
First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant 127
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 127
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 127
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 127
Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies 127
Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, the Netherlands 126
Excitation-contraction coupling of extensor digitorum longus muscle of dystrophic MDX mouse 125
(2) Save to: more options Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 124
Age-dependent modification of phosphorylation state of skeletal muscle chloride channel controls its biophysical and pharmacological properties 123
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 123
Mechanisms of block of sodium channels in human myoballs by local anaesthetics with different use dependence 122
The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation 122
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 122
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 122
Erratum: Corrigendum to “Isolation and characterization of neural stem cells from dystrophic mdx mouse” (Experimental Cell Research (2016) 343(1) (190–207) (S0014482716300593) (10.1016/j.yexcr.2016.03.019)) 121
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 121
"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic 121
β‐Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation 121
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 120
A decade of optimizing drug development for rare neuromuscular disorders through TACT 120
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 118
Taurine and skeletal muscle ion channels 118
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 118
A novel kcna2 variant in a patient with non-progressive congenital ataxia and epilepsy: Functional characterization and sensitivity to 4-aminopyridine 118
Prednisone in dystrophin-deficient Caernorabditis elegans 117
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 116
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 116
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 116
Safety issues and harmful pharmacological interactions of nutritional supplements in Duchenne muscular dystrophy: considerations for Standard of Care and emerging virus outbreaks 116
A new original compound, which inhibits calpain 1-2 and reactive oxygen species, reduces the dystrophic progression of mdx mice 115
Muscle loading modulates aquaporin-4 expression in skeletal muscle 114
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 114
Antitumorali 113
Circadian Genes as Exploratory Biomarkers in DMD: Results From Both the mdx Mouse Model and Patients 113
Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice. 112
Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia 111
Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy. 110
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 110
Taurine and skeletal muscle disorders 110
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 110
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 110
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 109
Skeletal muscle ClC-1 chloride channels in health and diseases 109
Totale 14.757
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Categoria #
all - tutte 134.103
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 134.103
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021163 0 0 0 0 0 0 0 0 0 0 0 163
2021/20221.994 70 285 22 114 85 116 105 113 120 137 310 517
2022/20233.187 494 268 199 307 393 441 21 343 533 30 87 71
2023/20241.430 89 231 49 83 98 224 158 295 16 55 22 110
2024/20254.954 144 70 388 154 130 460 468 492 225 259 729 1.435
2025/202610.037 1.485 462 1.035 1.022 1.102 540 1.417 338 1.067 1.042 367 160
Totale 31.910