IRIS
DE LUCA, Annamaria
 Distribuzione geografica
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Continente #
NA - Nord America 13.089
EU - Europa 2.507
AS - Asia 1.405
SA - Sud America 10
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 5
AF - Africa 4
Totale 17.028
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Nazione #
US - Stati Uniti d'America 13.067
CN - Cina 987
SE - Svezia 678
UA - Ucraina 487
IT - Italia 381
DE - Germania 333
SG - Singapore 276
FI - Finlandia 268
GB - Regno Unito 171
FR - Francia 70
IN - India 55
IE - Irlanda 38
BE - Belgio 36
VN - Vietnam 34
CA - Canada 22
IR - Iran 22
CZ - Repubblica Ceca 19
NL - Olanda 11
JP - Giappone 10
AU - Australia 6
HK - Hong Kong 6
BR - Brasile 5
EU - Europa 5
KR - Corea 5
RU - Federazione Russa 5
TR - Turchia 5
CL - Cile 3
AT - Austria 2
EG - Egitto 2
MA - Marocco 2
NZ - Nuova Zelanda 2
RO - Romania 2
VE - Venezuela 2
AE - Emirati Arabi Uniti 1
CH - Svizzera 1
DK - Danimarca 1
EE - Estonia 1
ES - Italia 1
ID - Indonesia 1
LV - Lettonia 1
MY - Malesia 1
NO - Norvegia 1
PH - Filippine 1
TH - Thailandia 1
Totale 17.028
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Città #
Fairfield 1.625
Woodbridge 1.335
Chandler 1.251
Ashburn 1.167
Jacksonville 1.125
Houston 927
Cambridge 680
Seattle 634
Wilmington 568
Ann Arbor 550
Nyköping 519
Lawrence 276
Roxbury 272
Nanjing 253
Singapore 226
Des Moines 177
Princeton 173
Beijing 168
Boardman 165
New York 134
Bari 130
Inglewood 119
San Diego 97
Nanchang 78
Hebei 70
Jiaxing 62
Los Angeles 55
Shenyang 49
Santa Clara 41
Tianjin 40
Dublin 37
Brussels 35
Dearborn 33
Dong Ket 33
Changsha 32
London 32
Pune 31
Milan 27
San Mateo 26
Falls Church 22
Helsinki 21
Leawood 21
Brooklyn 20
Guangzhou 20
Shanghai 20
Ardabil 19
Redwood City 19
Taranto 19
Zhengzhou 19
Brno 18
Augusta 17
Wuhan 17
Monmouth Junction 16
Jinan 15
Hefei 14
Paris 14
Ningbo 13
Washington 13
San Francisco 11
Prescot 10
Toronto 10
Munich 9
Kilburn 8
Kunming 8
Norwalk 8
Hounslow 7
Indiana 7
Ottawa 7
Tappahannock 7
Chicago 6
Jinhua 6
Camerino 5
Genova 5
Grafing 5
Hong Kong 5
Rome 5
Sennori 5
Wuxi 5
Auburn Hills 4
Campobello Di Mazara 4
Genoa 4
Islington 4
Marseille 4
Modugno 4
Montignoso 4
Mumbai 4
Simi Valley 4
Tokyo 4
Trani 4
Albairate 3
Clifton 3
Kiev 3
Melbourne 3
Montreal 3
Nagareyama 3
New Bedfont 3
Perugia 3
Phoenix 3
Quanzhou 3
Rende 3
Totale 13.805
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 413
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 138
Isolation and characterization of neural stem cells from dystrophic mdx mouse 136
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 131
Dasatinib/HP-β-CD inclusion complex based aqueous formulation as a promising tool for the treatment of paediatric neuromuscular disorders 125
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 124
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 124
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 114
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 112
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 112
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 108
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 107
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 106
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 104
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 103
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 103
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 101
Effetti di una nuova 1-4 diidropiridina, il Bay K 8644, su organi a muscolatura liscia isolati di cavia 100
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 100
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 100
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 100
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 99
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 99
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 96
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 95
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 94
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 94
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 93
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 93
null 92
Mechanisms of block of sodium channels in human myoballs by local anaesthetics with different use dependence 91
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 91
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 91
null 90
null 90
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 90
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 90
First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant 89
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 89
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 88
Taurine and skeletal muscle ion channels 88
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 88
Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy. 86
null 86
Changes of chloride channel regulation in rat skeletal muscle during aging 85
Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, the Netherlands 85
The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation 84
Excitation-contraction coupling of extensor digitorum longus muscle of dystrophic MDX mouse 84
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 84
Stakeholder cooperation to overcome challenges in orphan medicine development: The example of Duchenne muscular dystrophy 84
Prednisone in dystrophin-deficient Caernorabditis elegans 83
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 83
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 82
Evaluation of potential synergistic action of a combined treatment with alpha-methyl-prednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy. 81
Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds 81
Skeletal Muscle Chloride Channel, a Biophysical Sensor of Dystrophic Progression in Mdx Mouse, is a Potential Target of Pro-inflammatory Mediators 80
Muscle loading modulates aquaporin-4 expression in skeletal muscle 80
Aging and chloride channel regulation in rat fast-twitch muscle fibres 80
Drug screening for muscular dystrophy: From target to function toward patients, is anything lost? 79
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 79
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 79
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 78
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 78
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 77
PHARMACOLOGICAL BLOCK OF CHLORIDE CHANNELS DURING DEVELOPMENT AFFECTS CONTRACTILE AND ELECTRICAL-PROPERTIES OF RAT SKELETAL-MUSCLE 77
Enantiomers of tocainide and mexiletine: antimyotonic activity and use-dependent block of skeletal muscle Na+ channels 77
null 77
A stereospecific binding site regulates the C1- ion channel in rat skeletal muscle 77
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 76
null 75
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 75
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 75
null 75
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 74
Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse 73
null 73
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 73
Antimyotonic effects of enantiomers of mexiletine-like drugs 73
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 72
Taurine and skeletal muscle disorders 72
Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice. 71
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity 70
Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channels 70
Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation 70
Pharmacology of CLC chloride channels and transporters 70
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 70
Effects of chronic taurine treatment on the electrical and contractile properties of skeletal muscle fibers of aged rats 69
Dual effects of taurine on membrane ionic conductances of rat skeletal muscle fibers 69
null 69
null 69
Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline 68
Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy 68
null 68
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 68
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 68
Glial dystrophin-associated proteins, laminin and agrin, are downregulated in the brain of mdx mouse 67
Experimental evaluation of the effects of pravastatin on electrophysiological parameters of rat skeletal muscle 67
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 66
Modulatory pathways of skeletal muscle chloride channels from adult and aged rats 65
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 65
Totale 8.950
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Categoria #
all - tutte 75.667
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 75.667
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20203.090 0 0 117 366 437 242 444 333 492 219 350 90
2020/20212.863 314 134 221 282 309 104 203 153 271 422 287 163
2021/20221.994 70 285 22 114 85 116 105 113 120 137 310 517
2022/20233.208 498 271 201 309 395 444 21 346 535 30 87 71
2023/20241.437 89 232 49 84 98 228 158 295 16 56 22 110
2024/2025581 145 71 365 0 0 0 0 0 0 0 0 0
Totale 17.528