IRIS
DE LUCA, Annamaria
 Distribuzione geografica
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Continente #
NA - Nord America 13.250
EU - Europa 3.296
AS - Asia 2.044
SA - Sud America 544
AF - Africa 24
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 6
Totale 19.173
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Nazione #
US - Stati Uniti d'America 13.189
CN - Cina 1.039
SG - Singapore 691
SE - Svezia 678
RU - Federazione Russa 529
UA - Ucraina 498
BR - Brasile 497
IT - Italia 443
DE - Germania 402
FI - Finlandia 285
GB - Regno Unito 192
FR - Francia 89
IN - India 56
HK - Hong Kong 53
ID - Indonesia 53
BE - Belgio 46
CA - Canada 41
IE - Irlanda 38
VN - Vietnam 34
NL - Olanda 31
IR - Iran 27
CZ - Repubblica Ceca 19
AT - Austria 15
MX - Messico 14
TR - Turchia 14
AR - Argentina 12
JP - Giappone 11
UZ - Uzbekistan 11
IQ - Iraq 10
MA - Marocco 9
ES - Italia 8
BD - Bangladesh 7
CL - Cile 7
VE - Venezuela 7
AU - Australia 6
PK - Pakistan 6
AE - Emirati Arabi Uniti 5
BO - Bolivia 5
EC - Ecuador 5
EU - Europa 5
KR - Corea 5
LT - Lituania 5
ZA - Sudafrica 5
AZ - Azerbaigian 3
CI - Costa d'Avorio 3
CO - Colombia 3
DK - Danimarca 3
JO - Giordania 3
KG - Kirghizistan 3
NZ - Nuova Zelanda 3
PY - Paraguay 3
RO - Romania 3
UY - Uruguay 3
AL - Albania 2
CR - Costa Rica 2
EE - Estonia 2
EG - Egitto 2
HN - Honduras 2
KE - Kenya 2
KZ - Kazakistan 2
NO - Norvegia 2
OM - Oman 2
PA - Panama 2
PS - Palestinian Territory 2
RS - Serbia 2
AO - Angola 1
BY - Bielorussia 1
CH - Svizzera 1
DZ - Algeria 1
GY - Guiana 1
KH - Cambogia 1
LV - Lettonia 1
ML - Mali 1
MY - Malesia 1
NP - Nepal 1
PE - Perù 1
PH - Filippine 1
QA - Qatar 1
SA - Arabia Saudita 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 19.173
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Città #
Fairfield 1.625
Woodbridge 1.335
Chandler 1.251
Ashburn 1.175
Jacksonville 1.125
Houston 929
Cambridge 680
Seattle 634
Wilmington 568
Ann Arbor 550
Nyköping 519
Singapore 380
Lawrence 276
Roxbury 272
Nanjing 253
Des Moines 177
Princeton 173
Beijing 170
Boardman 166
Bari 148
New York 134
Inglewood 119
San Diego 97
Nanchang 78
Hebei 70
Jiaxing 62
Los Angeles 59
Hong Kong 52
Jakarta 52
Shenyang 49
Brussels 45
Santa Clara 43
London 41
Tianjin 40
Dublin 37
Helsinki 37
São Paulo 35
Changsha 33
Dearborn 33
Dong Ket 33
Pune 31
Milan 30
San Mateo 26
Guangzhou 24
Nuremberg 23
Shanghai 23
Council Bluffs 22
Falls Church 22
Moscow 22
Leawood 21
Brooklyn 20
Ardabil 19
Redwood City 19
Taranto 19
Toronto 19
Zhengzhou 19
Brno 18
Augusta 17
Wuhan 17
Falkenstein 16
Frankfurt am Main 16
Monmouth Junction 16
Grottaglie 15
Hefei 15
Jinan 15
Ottawa 14
Paris 14
Rio de Janeiro 14
Belo Horizonte 13
Ningbo 13
Washington 13
Brasília 11
Munich 11
San Francisco 11
Tashkent 11
Prescot 10
Curitiba 8
Kilburn 8
Kunming 8
Manaus 8
Mexico City 8
Norwalk 8
Vienna 8
Campinas 7
Düsseldorf 7
Hounslow 7
Indiana 7
Portsmouth 7
Rome 7
Tappahannock 7
Americana 6
Baghdad 6
Bauru 6
Chicago 6
Fortaleza 6
Jinhua 6
Lauterbourg 6
Porto Alegre 6
Camerino 5
Genova 5
Totale 14.357
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 416
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 152
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 148
Isolation and characterization of neural stem cells from dystrophic mdx mouse 147
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 145
Dasatinib/HP-β-CD inclusion complex based aqueous formulation as a promising tool for the treatment of paediatric neuromuscular disorders 143
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 135
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 134
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 133
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 128
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 126
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 118
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 117
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 117
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 116
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 115
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 114
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 112
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 111
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 110
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 109
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 107
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 105
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 104
Effetti di una nuova 1-4 diidropiridina, il Bay K 8644, su organi a muscolatura liscia isolati di cavia 103
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 103
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 103
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 102
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 101
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 101
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 101
Mechanisms of block of sodium channels in human myoballs by local anaesthetics with different use dependence 99
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 99
Aging and chloride channel regulation in rat fast-twitch muscle fibres 96
Changes of chloride channel regulation in rat skeletal muscle during aging 95
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 94
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 94
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 94
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 94
First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant 93
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 93
null 93
Taurine and skeletal muscle ion channels 92
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 92
Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, the Netherlands 92
Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds 92
null 91
Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy. 90
null 90
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 89
The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation 88
Excitation-contraction coupling of extensor digitorum longus muscle of dystrophic MDX mouse 88
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 88
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 88
Muscle loading modulates aquaporin-4 expression in skeletal muscle 87
Stakeholder cooperation to overcome challenges in orphan medicine development: The example of Duchenne muscular dystrophy 87
null 87
Prednisone in dystrophin-deficient Caernorabditis elegans 86
A stereospecific binding site regulates the C1- ion channel in rat skeletal muscle 86
Skeletal Muscle Chloride Channel, a Biophysical Sensor of Dystrophic Progression in Mdx Mouse, is a Potential Target of Pro-inflammatory Mediators 85
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 85
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 85
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 85
Drug screening for muscular dystrophy: From target to function toward patients, is anything lost? 83
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 83
Evaluation of potential synergistic action of a combined treatment with alpha-methyl-prednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy. 83
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 83
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 83
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 82
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 81
PHARMACOLOGICAL BLOCK OF CHLORIDE CHANNELS DURING DEVELOPMENT AFFECTS CONTRACTILE AND ELECTRICAL-PROPERTIES OF RAT SKELETAL-MUSCLE 80
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 79
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 79
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 79
227thENMC International Workshop:. Finalizing a plan to guarantee quality in translational research for neuromuscular diseases Heemskerk, Netherlands, 10-11 February 2017 79
Taurine and skeletal muscle disorders 78
null 78
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 78
Dual effects of taurine on membrane ionic conductances of rat skeletal muscle fibers 77
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 77
Enantiomers of tocainide and mexiletine: antimyotonic activity and use-dependent block of skeletal muscle Na+ channels 77
Aberrant mechanical-metabolic coupling in muscular dystrophy: gene expression and functional studies in mdx mouse muscle in relation to age and exercise 77
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 77
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity 76
Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse 76
Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice. 76
Antimyotonic effects of enantiomers of mexiletine-like drugs 76
Safety issues and harmful pharmacological interactions of nutritional supplements in Duchenne muscular dystrophy: considerations for Standard of Care and emerging virus outbreaks 76
null 76
Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies 76
null 75
Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation 75
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 75
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 74
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 74
Erratum: Corrigendum to “Isolation and characterization of neural stem cells from dystrophic mdx mouse” (Experimental Cell Research (2016) 343(1) (190–207) (S0014482716300593) (10.1016/j.yexcr.2016.03.019)) 74
Age-dependent modification of phosphorylation state of skeletal muscle chloride channel controls its biophysical and pharmacological properties 73
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers 73
null 73
Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channels 73
Totale 9.737
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Categoria #
all - tutte 91.732
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 91.732
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020440 0 0 0 0 0 0 0 0 0 0 350 90
2020/20212.863 314 134 221 282 309 104 203 153 271 422 287 163
2021/20221.994 70 285 22 114 85 116 105 113 120 137 310 517
2022/20233.208 498 271 201 309 395 444 21 346 535 30 87 71
2023/20241.437 89 232 49 84 98 228 158 295 16 56 22 110
2024/20252.841 145 71 390 154 131 462 473 495 226 262 32 0
Totale 19.788