IRIS
DE LUCA, Annamaria
 Distribuzione geografica
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Continente #
NA - Nord America 13.772
EU - Europa 3.618
AS - Asia 3.238
SA - Sud America 1.186
AF - Africa 64
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 6
Totale 21.894
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Nazione #
US - Stati Uniti d'America 13.656
BR - Brasile 1.093
CN - Cina 1.061
SG - Singapore 924
HK - Hong Kong 762
SE - Svezia 682
RU - Federazione Russa 534
IT - Italia 519
UA - Ucraina 503
DE - Germania 470
FI - Finlandia 300
GB - Regno Unito 246
FR - Francia 140
IN - India 99
VN - Vietnam 66
CA - Canada 62
ID - Indonesia 53
BD - Bangladesh 51
BE - Belgio 46
IE - Irlanda 40
IQ - Iraq 40
NL - Olanda 35
MX - Messico 34
TR - Turchia 31
AR - Argentina 29
IR - Iran 27
JP - Giappone 25
CZ - Repubblica Ceca 19
ZA - Sudafrica 19
AT - Austria 17
ES - Italia 17
UZ - Uzbekistan 17
VE - Venezuela 16
MA - Marocco 15
PL - Polonia 15
SA - Arabia Saudita 14
AE - Emirati Arabi Uniti 12
CO - Colombia 11
EC - Ecuador 11
PK - Pakistan 10
KE - Kenya 9
AU - Australia 7
CL - Cile 7
LT - Lituania 7
JO - Giordania 6
UY - Uruguay 6
BO - Bolivia 5
EG - Egitto 5
EU - Europa 5
KR - Corea 5
NP - Nepal 5
RS - Serbia 5
TT - Trinidad e Tobago 5
AL - Albania 4
AZ - Azerbaigian 4
CI - Costa d'Avorio 4
IL - Israele 4
KZ - Kazakistan 4
OM - Oman 4
PA - Panama 4
PE - Perù 4
DK - Danimarca 3
EE - Estonia 3
HN - Honduras 3
JM - Giamaica 3
KG - Kirghizistan 3
NZ - Nuova Zelanda 3
PY - Paraguay 3
RO - Romania 3
TN - Tunisia 3
BH - Bahrain 2
BY - Bielorussia 2
CR - Costa Rica 2
DZ - Algeria 2
ET - Etiopia 2
NI - Nicaragua 2
NO - Norvegia 2
PS - Palestinian Territory 2
SN - Senegal 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BS - Bahamas 1
CH - Svizzera 1
GR - Grecia 1
GY - Guiana 1
KH - Cambogia 1
KW - Kuwait 1
LB - Libano 1
LV - Lettonia 1
ML - Mali 1
MY - Malesia 1
NG - Nigeria 1
PH - Filippine 1
PT - Portogallo 1
QA - Qatar 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 21.894
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Città #
Fairfield 1.626
Woodbridge 1.335
Chandler 1.251
Ashburn 1.200
Jacksonville 1.127
Houston 929
Hong Kong 760
Cambridge 680
Seattle 637
Singapore 607
Wilmington 568
Ann Arbor 550
Nyköping 519
Lawrence 276
Roxbury 272
Nanjing 253
Beijing 186
Des Moines 177
Princeton 173
Boardman 167
Bari 154
New York 152
Inglewood 119
San Diego 97
Los Angeles 83
Nanchang 78
São Paulo 78
Hebei 70
Jiaxing 62
Munich 62
Santa Clara 53
Jakarta 52
London 50
Shenyang 49
Brussels 45
Tianjin 40
Dublin 38
Helsinki 38
Pune 35
Bitetto 33
Changsha 33
Dearborn 33
Dong Ket 33
Milan 32
Rio de Janeiro 32
Brooklyn 30
Bitonto 29
Nuremberg 29
Belo Horizonte 27
Shanghai 27
San Mateo 26
The Dalles 26
Frankfurt am Main 25
Columbus 24
Guangzhou 24
Moscow 23
San Francisco 23
Council Bluffs 22
Falls Church 22
Toronto 22
Brasília 21
Leawood 21
Ardabil 19
Baghdad 19
Redwood City 19
Taranto 19
Zhengzhou 19
Brno 18
Augusta 17
Chicago 17
Wuhan 17
Falkenstein 16
Monmouth Junction 16
Tashkent 16
Campinas 15
Curitiba 15
Grottaglie 15
Hefei 15
Jinan 15
Paris 15
Mexico City 14
Ottawa 14
Turku 14
Washington 14
Ningbo 13
Caxias do Sul 12
Hanoi 12
Tokyo 12
Goiânia 11
Ho Chi Minh City 11
Montreal 11
Dhaka 10
Guarulhos 10
Prescot 10
Warsaw 10
Betim 9
Charlotte 9
Düsseldorf 9
Fortaleza 9
Manaus 9
Totale 15.790
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 430
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 206
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 167
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 158
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 158
Isolation and characterization of neural stem cells from dystrophic mdx mouse 155
Dasatinib/HP-β-CD inclusion complex based aqueous formulation as a promising tool for the treatment of paediatric neuromuscular disorders 150
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 150
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 143
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 142
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 134
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 134
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 129
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 129
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 126
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 125
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 124
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 123
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 121
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 120
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 118
Effetti di una nuova 1-4 diidropiridina, il Bay K 8644, su organi a muscolatura liscia isolati di cavia 117
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 117
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 116
Myasthenia Gravis Treatment: From Old Drugs to Innovative Therapies with a Glimpse into the Future 115
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 114
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 113
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 113
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 112
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 111
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 111
Aging and chloride channel regulation in rat fast-twitch muscle fibres 108
Changes of chloride channel regulation in rat skeletal muscle during aging 106
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 106
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 105
Mechanisms of block of sodium channels in human myoballs by local anaesthetics with different use dependence 104
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 104
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 104
First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant 103
Taurine and skeletal muscle ion channels 102
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 101
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 100
Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds 100
The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation 99
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 99
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 99
Stakeholder cooperation to overcome challenges in orphan medicine development: The example of Duchenne muscular dystrophy 99
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 99
Excitation-contraction coupling of extensor digitorum longus muscle of dystrophic MDX mouse 98
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 98
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 98
Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, the Netherlands 98
Prednisone in dystrophin-deficient Caernorabditis elegans 97
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 97
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 95
Muscle loading modulates aquaporin-4 expression in skeletal muscle 94
A stereospecific binding site regulates the C1- ion channel in rat skeletal muscle 94
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 94
Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy. 93
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 93
null 93
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 93
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 92
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 92
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 92
null 91
Evaluation of potential synergistic action of a combined treatment with alpha-methyl-prednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy. 91
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 91
Drug screening for muscular dystrophy: From target to function toward patients, is anything lost? 90
null 90
Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx mice. 90
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 90
Aberrant mechanical-metabolic coupling in muscular dystrophy: gene expression and functional studies in mdx mouse muscle in relation to age and exercise 90
227thENMC International Workshop:. Finalizing a plan to guarantee quality in translational research for neuromuscular diseases Heemskerk, Netherlands, 10-11 February 2017 90
Skeletal Muscle Chloride Channel, a Biophysical Sensor of Dystrophic Progression in Mdx Mouse, is a Potential Target of Pro-inflammatory Mediators 89
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 89
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 88
PHARMACOLOGICAL BLOCK OF CHLORIDE CHANNELS DURING DEVELOPMENT AFFECTS CONTRACTILE AND ELECTRICAL-PROPERTIES OF RAT SKELETAL-MUSCLE 88
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 88
Taurine and skeletal muscle disorders 88
Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies 88
Age-dependent modification of phosphorylation state of skeletal muscle chloride channel controls its biophysical and pharmacological properties 87
Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse 87
Antimyotonic effects of enantiomers of mexiletine-like drugs 87
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 87
null 87
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 86
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity 85
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers 85
Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation 85
Erratum: Corrigendum to “Isolation and characterization of neural stem cells from dystrophic mdx mouse” (Experimental Cell Research (2016) 343(1) (190–207) (S0014482716300593) (10.1016/j.yexcr.2016.03.019)) 85
Dual effects of taurine on membrane ionic conductances of rat skeletal muscle fibers 84
Enantiomers of tocainide and mexiletine: antimyotonic activity and use-dependent block of skeletal muscle Na+ channels 83
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 83
Pharmacology of CLC chloride channels and transporters 82
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 82
A new original compound, which inhibits calpain 1-2 and reactive oxygen species, reduces the dystrophic progression of mdx mice 81
Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channels 81
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 81
Safety issues and harmful pharmacological interactions of nutritional supplements in Duchenne muscular dystrophy: considerations for Standard of Care and emerging virus outbreaks 81
Totale 10.760
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Categoria #
all - tutte 99.291
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 99.291
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20212.863 314 134 221 282 309 104 203 153 271 422 287 163
2021/20221.994 70 285 22 114 85 116 105 113 120 137 310 517
2022/20233.208 498 271 201 309 395 444 21 346 535 30 87 71
2023/20241.437 89 232 49 84 98 228 158 295 16 56 22 110
2024/20254.991 145 71 390 154 131 462 473 495 226 262 736 1.446
2025/2026572 572 0 0 0 0 0 0 0 0 0 0 0
Totale 22.510