IRIS
DE LUCA, Annamaria
 Distribuzione geografica
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Continente #
NA - Nord America 18.662
AS - Asia 7.132
EU - Europa 5.889
SA - Sud America 1.901
Continente sconosciuto - Info sul continente non disponibili 666
AF - Africa 269
OC - Oceania 18
AN - Antartide 1
Totale 34.538
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Nazione #
US - Stati Uniti d'America 18.336
SG - Singapore 3.078
IT - Italia 2.046
CN - Cina 1.589
BR - Brasile 1.519
HK - Hong Kong 901
SE - Svezia 697
RU - Federazione Russa 555
DE - Germania 528
UA - Ucraina 517
FR - Francia 422
FI - Finlandia 412
VN - Vietnam 391
GB - Regno Unito 316
IN - India 234
BD - Bangladesh 221
CA - Canada 167
AR - Argentina 127
ID - Indonesia 108
IQ - Iraq 97
MX - Messico 80
TR - Turchia 73
NL - Olanda 64
CO - Colombia 63
ZA - Sudafrica 61
JP - Giappone 60
EC - Ecuador 53
CI - Costa d'Avorio 52
BE - Belgio 49
ES - Italia 48
IE - Irlanda 47
PK - Pakistan 47
PL - Polonia 43
CL - Cile 40
SA - Arabia Saudita 39
VE - Venezuela 39
MA - Marocco 36
UZ - Uzbekistan 34
IR - Iran 29
AT - Austria 27
EG - Egitto 24
PH - Filippine 23
AE - Emirati Arabi Uniti 22
KE - Kenya 21
MY - Malesia 21
CZ - Repubblica Ceca 20
JO - Giordania 19
TN - Tunisia 18
UY - Uruguay 18
DZ - Algeria 16
NP - Nepal 16
PE - Perù 16
AU - Australia 15
PY - Paraguay 15
CR - Costa Rica 14
HN - Honduras 14
IL - Israele 14
LT - Lituania 14
KR - Corea 13
KZ - Kazakistan 12
AZ - Azerbaigian 10
BO - Bolivia 10
ET - Etiopia 10
KG - Kirghizistan 9
RS - Serbia 9
TH - Thailandia 9
TW - Taiwan 9
AL - Albania 8
JM - Giamaica 8
NI - Nicaragua 8
OM - Oman 8
PS - Palestinian Territory 8
RO - Romania 8
SV - El Salvador 8
TT - Trinidad e Tobago 8
HU - Ungheria 7
LB - Libano 7
AO - Angola 6
CH - Svizzera 6
DK - Danimarca 6
GE - Georgia 6
GR - Grecia 6
PA - Panama 6
PT - Portogallo 6
EU - Europa 5
EE - Estonia 4
GT - Guatemala 4
KH - Cambogia 4
NG - Nigeria 4
NO - Norvegia 4
SC - Seychelles 4
SN - Senegal 4
BY - Bielorussia 3
HR - Croazia 3
KW - Kuwait 3
LV - Lettonia 3
LY - Libia 3
ME - Montenegro 3
NZ - Nuova Zelanda 3
QA - Qatar 3
Totale 33.833
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Città #
Ashburn 1.913
Singapore 1.676
Fairfield 1.626
Woodbridge 1.335
Chandler 1.245
San Jose 1.136
Jacksonville 1.130
Houston 939
Hong Kong 892
Milan 736
Cambridge 684
Dallas 647
Seattle 644
Wilmington 571
Ann Arbor 550
Nyköping 512
Council Bluffs 445
Beijing 410
Lawrence 274
Roxbury 272
Bari 270
Lauterbourg 266
Nanjing 255
New York 246
Rome 229
Los Angeles 227
Boardman 184
Des Moines 178
Princeton 172
Santa Clara 143
Helsinki 138
Ho Chi Minh City 128
Inglewood 119
São Paulo 117
San Diego 98
Columbus 96
Hanoi 91
Nanchang 79
Buffalo 75
Chicago 71
Hebei 70
Jiaxing 62
Munich 62
Jakarta 61
Brooklyn 56
London 56
Abidjan 50
Shenyang 49
Brussels 46
Baghdad 45
Frankfurt am Main 45
Figino 43
Dublin 42
Turin 42
Rio de Janeiro 41
San Francisco 41
Tianjin 41
Tokyo 40
Bitetto 38
Brasília 37
Falkenstein 36
Pune 36
Toronto 36
Changsha 35
Dearborn 35
Chennai 33
Dong Ket 33
Nuremberg 33
Warsaw 33
Belo Horizonte 32
Montreal 32
Phoenix 31
Shanghai 31
Tashkent 31
Bitonto 30
Mexico City 30
Orem 30
Taranto 30
The Dalles 30
Victoria 29
San Mateo 27
Denver 26
Stockholm 26
Turku 26
Guangzhou 25
Moscow 25
Johannesburg 23
Medellín 23
Paris 23
Curitiba 22
Falls Church 22
Atlanta 21
Leawood 21
Zhengzhou 21
Augusta 20
Bologna 20
Campinas 20
Naples 20
Santiago 20
Washington 20
Totale 22.883
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 469
Myasthenia Gravis Treatment: From Old Drugs to Innovative Therapies with a Glimpse into the Future 346
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 297
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 249
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 248
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 238
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 234
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 234
Dasatinib/HP-β-CD inclusion complex based aqueous formulation as a promising tool for the treatment of paediatric neuromuscular disorders 213
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 207
Isolation and characterization of neural stem cells from dystrophic mdx mouse 206
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 205
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 204
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 198
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 196
GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy 192
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 184
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 177
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 169
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 166
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 165
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 165
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 164
Aging and chloride channel regulation in rat fast-twitch muscle fibres 161
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 161
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 159
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 158
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 158
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 158
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 158
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 156
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 156
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 155
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 155
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 154
Aberrant mechanical-metabolic coupling in muscular dystrophy: gene expression and functional studies in mdx mouse muscle in relation to age and exercise 154
Stakeholder cooperation to overcome challenges in orphan medicine development: The example of Duchenne muscular dystrophy 151
Alteration of stim1/orai1-mediated soce in skeletal muscle: Impact in genetic muscle diseases and beyond 150
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 148
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 148
Changes of chloride channel regulation in rat skeletal muscle during aging 147
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 146
227thENMC International Workshop:. Finalizing a plan to guarantee quality in translational research for neuromuscular diseases Heemskerk, Netherlands, 10-11 February 2017 146
A stereospecific binding site regulates the C1- ion channel in rat skeletal muscle 144
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 144
Ultrasonography validation for early alteration of diaphragm echodensity and function in the mdx mouse model of Duchenne muscular dystrophy 143
Effetti di una nuova 1-4 diidropiridina, il Bay K 8644, su organi a muscolatura liscia isolati di cavia 142
Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds 142
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 141
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 141
Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies 140
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 139
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers 138
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 138
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 138
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 137
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 137
"The Social Network" and Muscular Dystrophies: The Lesson Learnt about the Niche Environment as a Target for Therapeutic Strategies 136
(2) Save to: more options Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 135
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 135
Age-dependent modification of phosphorylation state of skeletal muscle chloride channel controls its biophysical and pharmacological properties 134
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 133
First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant 133
Update on Standard Operating Procedures in Preclinical Research for DMD and SMA Report of TREAT-NMD Alliance Workshop, Schiphol Airport, 26 April 2015, the Netherlands 133
LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model 132
Excitation-contraction coupling of extensor digitorum longus muscle of dystrophic MDX mouse 132
"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic 131
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 130
The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation 129
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 129
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 128
Prednisone in dystrophin-deficient Caernorabditis elegans 128
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 128
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 127
Mechanisms of block of sodium channels in human myoballs by local anaesthetics with different use dependence 126
A decade of optimizing drug development for rare neuromuscular disorders through TACT 126
A new original compound, which inhibits calpain 1-2 and reactive oxygen species, reduces the dystrophic progression of mdx mice 125
Erratum: Corrigendum to “Isolation and characterization of neural stem cells from dystrophic mdx mouse” (Experimental Cell Research (2016) 343(1) (190–207) (S0014482716300593) (10.1016/j.yexcr.2016.03.019)) 125
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 125
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy 124
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 124
Antitumorali 124
A novel kcna2 variant in a patient with non-progressive congenital ataxia and epilepsy: Functional characterization and sensitivity to 4-aminopyridine 124
β‐Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation 124
Alterazioni delle proprietà biofisiche dei canali al K+ del muscolo scheletrico di ratto prodotte dall'esposizione prenatale a monossido di carbonio 121
Muscle loading modulates aquaporin-4 expression in skeletal muscle 121
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 121
Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation 121
Gain-of-Function STIM1 L96V Mutation Causes Myogenesis Alteration in Muscle Cells From a Patient Affected by Tubular Aggregate Myopathy 121
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 120
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 120
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 120
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 120
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 120
Circadian Genes as Exploratory Biomarkers in DMD: Results From Both the mdx Mouse Model and Patients 120
Taurine and skeletal muscle ion channels 119
Safety issues and harmful pharmacological interactions of nutritional supplements in Duchenne muscular dystrophy: considerations for Standard of Care and emerging virus outbreaks 119
Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia 118
Taurine and skeletal muscle disorders 118
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 117
Totale 15.565
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Categoria #
all - tutte 142.462
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 142.462
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.639 0 0 22 114 85 116 105 113 120 137 310 517
2022/20233.187 494 268 199 307 393 441 21 343 533 30 87 71
2023/20241.430 89 231 49 83 98 224 158 295 16 55 22 110
2024/20254.954 144 70 388 154 130 460 468 492 225 259 729 1.435
2025/202611.214 1.485 462 1.035 1.022 1.102 540 1.417 338 1.067 1.042 367 1.337
2026/20271.451 482 623 346 0 0 0 0 0 0 0 0 0
Totale 34.538