IRIS
PIERNO, Sabata
 Distribuzione geografica
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Continente #
NA - Nord America 8.160
AS - Asia 2.992
EU - Europa 2.431
SA - Sud America 732
Continente sconosciuto - Info sul continente non disponibili 336
AF - Africa 115
OC - Oceania 7
Totale 14.773
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Nazione #
US - Stati Uniti d'America 8.049
SG - Singapore 1.294
IT - Italia 782
CN - Cina 705
BR - Brasile 598
HK - Hong Kong 358
SE - Svezia 351
RU - Federazione Russa 243
DE - Germania 199
UA - Ucraina 199
FR - Francia 179
FI - Finlandia 164
VN - Vietnam 163
GB - Regno Unito 148
IN - India 106
BD - Bangladesh 93
ID - Indonesia 51
CA - Canada 48
AR - Argentina 47
MX - Messico 35
ZA - Sudafrica 28
NL - Olanda 26
BE - Belgio 24
TR - Turchia 24
IQ - Iraq 22
CI - Costa d'Avorio 21
JP - Giappone 20
PL - Polonia 20
EC - Ecuador 19
PK - Pakistan 19
CL - Cile 18
ES - Italia 18
CO - Colombia 15
UZ - Uzbekistan 15
VE - Venezuela 15
IE - Irlanda 14
KE - Kenya 14
MA - Marocco 14
SA - Arabia Saudita 14
LT - Lituania 11
TN - Tunisia 11
AT - Austria 10
CZ - Repubblica Ceca 10
IR - Iran 10
KR - Corea 10
MY - Malesia 10
PH - Filippine 9
CR - Costa Rica 8
PY - Paraguay 8
IL - Israele 7
KZ - Kazakistan 7
NP - Nepal 7
JO - Giordania 6
KG - Kirghizistan 6
PE - Perù 6
AL - Albania 5
AU - Australia 5
EG - Egitto 5
PS - Palestinian Territory 5
AE - Emirati Arabi Uniti 4
ET - Etiopia 4
OM - Oman 4
SV - El Salvador 4
UY - Uruguay 4
AO - Angola 3
DZ - Algeria 3
HR - Croazia 3
JM - Giamaica 3
NG - Nigeria 3
NI - Nicaragua 3
NO - Norvegia 3
PA - Panama 3
TH - Thailandia 3
TW - Taiwan 3
AM - Armenia 2
AZ - Azerbaigian 2
BN - Brunei Darussalam 2
BO - Bolivia 2
BY - Bielorussia 2
DK - Danimarca 2
EU - Europa 2
GR - Grecia 2
HN - Honduras 2
HU - Ungheria 2
KH - Cambogia 2
LY - Libia 2
NZ - Nuova Zelanda 2
RO - Romania 2
RS - Serbia 2
SN - Senegal 2
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BH - Bahrain 1
CG - Congo 1
CH - Svizzera 1
CY - Cipro 1
DM - Dominica 1
DO - Repubblica Dominicana 1
EE - Estonia 1
GE - Georgia 1
Totale 14.420
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Città #
Ashburn 1.065
Fairfield 841
Singapore 715
Woodbridge 608
Chandler 536
Jacksonville 436
Houston 397
San Jose 390
Hong Kong 357
Seattle 333
Milan 315
Cambridge 310
Dallas 295
Nyköping 284
Ann Arbor 278
Wilmington 257
Beijing 193
Nanjing 116
Lawrence 110
Roxbury 110
Lauterbourg 107
Bari 105
Los Angeles 97
Princeton 92
Rome 92
New York 81
Boardman 73
Inglewood 67
Des Moines 64
Council Bluffs 58
Santa Clara 55
São Paulo 52
Helsinki 49
Ho Chi Minh City 49
Hanoi 41
San Diego 37
Jakarta 34
Columbus 33
Nanchang 30
Buffalo 29
Hebei 29
Jiaxing 29
Chicago 28
London 27
Munich 27
Dong Ket 26
The Dalles 25
Brooklyn 24
Pune 24
Brussels 23
Figino 23
Shenyang 22
Toronto 20
Turin 20
Abidjan 19
Frankfurt am Main 17
Mexico City 17
Rio de Janeiro 17
Guangzhou 16
Tokyo 16
Warsaw 16
Falls Church 15
Phoenix 15
Turku 15
Belo Horizonte 14
Changsha 14
Dublin 14
Falkenstein 14
Moscow 14
San Francisco 14
San Mateo 14
Shanghai 14
Brasília 13
Chennai 13
Denver 13
Zhengzhou 13
Atlanta 12
Manchester 12
Monmouth Junction 12
Tashkent 12
Charlotte 11
Dearborn 11
Orem 11
Redwood City 11
Augusta 10
Baghdad 10
Brno 10
Johannesburg 10
Leawood 10
Montreal 10
Nairobi 10
Stockholm 10
Tianjin 10
Wuhan 10
Ardabil 9
Santiago 9
Boston 8
Dhaka 8
Genova 8
Ningbo 8
Totale 10.107
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 468
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 246
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 246
Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles 206
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 206
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 203
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 201
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 197
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 194
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 189
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 183
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 169
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 163
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 162
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 161
Aging and chloride channel regulation in rat fast-twitch muscle fibres 160
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 157
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 156
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 154
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 154
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 153
The biophysical and pharmacological characteristics of skeletal muscle ATP-Sensitive K+ channels are modified in K+-depleted rat, an animal model of hypokalemic periodic paralysis 152
Changes in Expression and Cellular Localization of Rat Skeletal Muscle ClC-1 Chloride Channel in Relation to Age, Myofiber Phenotype and PKC Modulation 150
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 147
Changes of chloride channel regulation in rat skeletal muscle during aging 146
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 145
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 143
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 141
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 140
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 140
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 138
Redox homeostasis, oxidative stress and disuse muscle atrophy 136
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 136
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 135
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 135
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 134
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers 132
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 132
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 132
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb unloaded mice 129
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 129
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 128
Increased sarcolemma chloride conductance as one of the mechanisms of action of carbonic anhydrase inhibitors in muscle excitability disorders 128
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 127
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 126
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 125
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 123
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 122
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 121
Taurine and skeletal muscle ion channels 119
Muscle loading modulates aquaporin-4 expression in skeletal muscle 119
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 117
Taurine and skeletal muscle disorders 116
Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation 114
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 114
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 112
Statin‐induced myopathy: Translational studies from preclinical to clinical evidence 111
Dual effects of taurine on membrane ionic conductances of rat skeletal muscle fibers 108
An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function 108
Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle 107
Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle 107
Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance 105
Growth hormone secretagogues exert differential effects on skeletal muscle calcium homeostasis in male rats depending on the peptidyl/non-peptidyl structure 105
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 104
Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channels 104
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 104
Experimental evaluation of the effects of pravastatin on electrophysiological parameters of rat skeletal muscle 104
EFFECTS OF TAURINE DEPLETION ON MEMBRANE ELECTIRCL PROPERTIES OF RAT SKELETAL MUSCLE. 103
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 100
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 100
Effects of chronic taurine treatment on the electrical and contractile properties of skeletal muscle fibers of aged rats 100
null 100
Comparison of excitability parameters and sodium channel behavior of fast- and slow-twitch rat skeletal muscles for the study of the effects of hindlimb suspension, a model of hypogravity. 98
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 98
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 97
Taurine and skeletal muscle ion channels 97
An olive oil–derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function 97
Hypertriglyceridemia Therapy: Past, Present and Future Perspectives 96
Therapeutic approaches to ion channel diseases 96
Potential targets for skeletal muscle impairment by hypogravity: basic characterization of resting ionic conductances and mechanical threshold of rat fast- and slow-twitch muscle fibers 96
Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders 96
Therapeutic approaches to ion channel diseases 95
Skeletal muscle disuse fiber type-dependent enhancement of Na+ channel expression 94
null 93
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 91
Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels 90
null 90
Cardiovascular, neurological, and pulmonary events following vaccination with the BNT162b2, ChAdOx1 nCoV-19, and Ad26.COV2.S vaccines: An analysis of European data 90
Molecular mechanisms responsible for fluvastatin and fenofibrateinduced reduction of resting membrane chloride conductance in rat skeletal muscle 88
Preclinical study of the antimyotonic efficacy of safinamide in the myotonic mouse model 87
null 87
Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle 86
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function 86
Angiotensin II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1 receptor and NADPH oxidase. 85
Modification of resting chloride conductance during and after recovery from hindlimb unloading 85
Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse 85
Higher content of insulin-like growth factor-1 in dystrophic mdx mouse: potential role in the spontaneous regeneration through an electrophysiological investigation of muscle function 84
Cyclic amidine analogs of taurine and homotaurine: synthesis and effects on rat skeletal muscle 81
Role of tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach 80
Metabolic Pathways and Ion Channels Involved in Skeletal Muscle Atrophy: A Starting Point for Potential Therapeutic Strategies 79
Totale 12.908
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Categoria #
all - tutte 61.012
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 61.012
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022861 0 159 9 32 49 48 53 36 83 54 142 196
2022/20231.392 218 138 106 121 167 201 5 151 201 6 44 34
2023/2024805 35 94 19 41 41 86 147 275 3 11 6 47
2024/20252.072 78 35 147 71 64 189 193 199 90 106 288 612
2025/20264.633 610 224 445 381 445 225 575 152 456 410 133 577
2026/2027163 142 21 0 0 0 0 0 0 0 0 0 0
Totale 14.773