IRIS
PIERNO, Sabata
 Distribuzione geografica
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Continente #
NA - Nord America 7.186
AS - Asia 2.330
EU - Europa 1.655
SA - Sud America 597
AF - Africa 56
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 2
Totale 11.831
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Nazione #
US - Stati Uniti d'America 7.118
SG - Singapore 1.026
CN - Cina 634
BR - Brasile 521
SE - Svezia 350
HK - Hong Kong 330
RU - Federazione Russa 236
IT - Italia 227
UA - Ucraina 194
DE - Germania 182
GB - Regno Unito 138
FI - Finlandia 133
VN - Vietnam 103
IN - India 65
FR - Francia 64
CA - Canada 38
ID - Indonesia 36
AR - Argentina 29
BD - Bangladesh 25
BE - Belgio 24
CI - Costa d'Avorio 20
MX - Messico 18
PL - Polonia 17
TR - Turchia 15
IQ - Iraq 14
NL - Olanda 14
ES - Italia 13
IE - Irlanda 13
JP - Giappone 12
AT - Austria 10
CL - Cile 10
CZ - Repubblica Ceca 10
IR - Iran 10
LT - Lituania 10
ZA - Sudafrica 10
EC - Ecuador 9
KR - Corea 9
VE - Venezuela 8
IL - Israele 6
KE - Kenya 6
MA - Marocco 6
PY - Paraguay 6
UZ - Uzbekistan 6
CO - Colombia 5
CR - Costa Rica 4
KG - Kirghizistan 4
PK - Pakistan 4
UY - Uruguay 4
AU - Australia 3
EG - Egitto 3
JO - Giordania 3
KZ - Kazakistan 3
NG - Nigeria 3
NO - Norvegia 3
NP - Nepal 3
PE - Perù 3
SA - Arabia Saudita 3
AL - Albania 2
BN - Brunei Darussalam 2
BO - Bolivia 2
BY - Bielorussia 2
DK - Danimarca 2
EU - Europa 2
KH - Cambogia 2
NZ - Nuova Zelanda 2
OM - Oman 2
PA - Panama 2
PS - Palestinian Territory 2
RS - Serbia 2
SN - Senegal 2
TN - Tunisia 2
AE - Emirati Arabi Uniti 1
AM - Armenia 1
AO - Angola 1
AZ - Azerbaigian 1
BH - Bahrain 1
DM - Dominica 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
EE - Estonia 1
GR - Grecia 1
HR - Croazia 1
JM - Giamaica 1
LA - Repubblica Popolare Democratica del Laos 1
MD - Moldavia 1
MK - Macedonia 1
MM - Myanmar 1
MN - Mongolia 1
MT - Malta 1
MY - Malesia 1
NI - Nicaragua 1
PH - Filippine 1
PT - Portogallo 1
QA - Qatar 1
RO - Romania 1
SD - Sudan 1
SK - Slovacchia (Repubblica Slovacca) 1
SV - El Salvador 1
TH - Thailandia 1
TT - Trinidad e Tobago 1
Totale 11.830
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Città #
Ashburn 970
Fairfield 841
Woodbridge 608
Chandler 536
Singapore 506
Jacksonville 436
Houston 395
Seattle 333
Hong Kong 329
Cambridge 310
Dallas 287
Nyköping 284
Ann Arbor 278
Wilmington 256
Beijing 174
Nanjing 116
Lawrence 110
Roxbury 110
Bari 100
Princeton 91
Los Angeles 88
Inglewood 67
Boardman 63
Des Moines 63
New York 62
São Paulo 47
San Diego 37
Jakarta 32
Nanchang 30
Hebei 29
Ho Chi Minh City 29
Jiaxing 29
Santa Clara 29
Buffalo 28
Munich 27
Dong Ket 26
London 26
Chicago 25
Hanoi 24
Pune 24
Brussels 23
Shenyang 22
Brooklyn 21
The Dalles 20
Columbus 19
Abidjan 18
Helsinki 18
Council Bluffs 17
Toronto 16
Warsaw 16
Falls Church 15
Guangzhou 15
Turku 15
Changsha 14
Rio de Janeiro 14
San Francisco 14
San Mateo 14
Belo Horizonte 13
Dublin 13
Moscow 13
Shanghai 13
Zhengzhou 13
Brasília 12
Monmouth Junction 12
Chennai 11
Dearborn 11
Frankfurt am Main 11
Phoenix 11
Redwood City 11
Atlanta 10
Brno 10
Charlotte 10
Leawood 10
Mexico City 10
Tianjin 10
Tokyo 10
Wuhan 10
Ardabil 9
Augusta 9
Denver 9
Manchester 9
Milan 9
Stockholm 9
Boston 8
Genova 8
Ningbo 8
Nuremberg 8
Salt Lake City 8
Düsseldorf 7
Falkenstein 7
Hefei 7
Johannesburg 7
Paris 7
Dhaka 6
Jinan 6
Montreal 6
Norwalk 6
Ottawa 6
Seoul 6
Tashkent 6
Totale 8.541
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 439
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 206
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 181
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 177
Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles 175
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 169
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 162
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 161
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 161
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 161
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 153
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 150
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 145
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 142
Aging and chloride channel regulation in rat fast-twitch muscle fibres 139
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 137
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 135
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 133
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 130
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 129
The biophysical and pharmacological characteristics of skeletal muscle ATP-Sensitive K+ channels are modified in K+-depleted rat, an animal model of hypokalemic periodic paralysis 129
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 126
Changes of chloride channel regulation in rat skeletal muscle during aging 124
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 124
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 121
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 121
Redox homeostasis, oxidative stress and disuse muscle atrophy 120
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 120
Changes in Expression and Cellular Localization of Rat Skeletal Muscle ClC-1 Chloride Channel in Relation to Age, Myofiber Phenotype and PKC Modulation 118
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 118
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb unloaded mice 117
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 115
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 114
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 114
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 113
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 113
Taurine and skeletal muscle ion channels 112
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 112
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 112
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 110
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers 109
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 108
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 108
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 108
Muscle loading modulates aquaporin-4 expression in skeletal muscle 107
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 105
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 105
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 104
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 101
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 101
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 101
null 100
Taurine and skeletal muscle disorders 98
Growth hormone secretagogues exert differential effects on skeletal muscle calcium homeostasis in male rats depending on the peptidyl/non-peptidyl structure 98
Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation 93
Dual effects of taurine on membrane ionic conductances of rat skeletal muscle fibers 93
null 93
Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle 93
Increased sarcolemma chloride conductance as one of the mechanisms of action of carbonic anhydrase inhibitors in muscle excitability disorders 92
null 90
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 90
Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channels 89
An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function 89
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 87
Taurine and skeletal muscle ion channels 87
null 87
Effects of chronic taurine treatment on the electrical and contractile properties of skeletal muscle fibers of aged rats 86
Experimental evaluation of the effects of pravastatin on electrophysiological parameters of rat skeletal muscle 86
Therapeutic approaches to ion channel diseases 85
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 85
Therapeutic approaches to ion channel diseases 85
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 85
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 84
Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance 84
Potential targets for skeletal muscle impairment by hypogravity: basic characterization of resting ionic conductances and mechanical threshold of rat fast- and slow-twitch muscle fibers 84
Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders 83
Comparison of excitability parameters and sodium channel behavior of fast- and slow-twitch rat skeletal muscles for the study of the effects of hindlimb suspension, a model of hypogravity. 82
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 80
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 79
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 78
Skeletal muscle disuse fiber type-dependent enhancement of Na+ channel expression 78
Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle 77
An olive oil–derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function 75
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 74
EFFECTS OF TAURINE DEPLETION ON MEMBRANE ELECTIRCL PROPERTIES OF RAT SKELETAL MUSCLE. 71
Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle 71
Higher content of insulin-like growth factor-1 in dystrophic mdx mouse: potential role in the spontaneous regeneration through an electrophysiological investigation of muscle function 70
Modification of resting chloride conductance during and after recovery from hindlimb unloading 70
null 70
Molecular mechanisms responsible for fluvastatin and fenofibrateinduced reduction of resting membrane chloride conductance in rat skeletal muscle 69
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function 68
null 68
Statin‐induced myopathy: Translational studies from preclinical to clinical evidence 66
Pharmacological interventions for the changes of chloride channel conductance of aging rat skeletal muscle 65
Angiotensin II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1 receptor and NADPH oxidase. 64
Excitation-contraction coupling is altered in skeletal muscle of dystrophic mdx mouse 63
Cyclic amidine analogs of taurine and homotaurine: synthesis and effects on rat skeletal muscle 63
Growth hormone secretagogues modulate the electrical an contractile properties of rat skeletal muscle through a ghrelin-specific receptor 63
Role of tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach 61
Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels 60
Totale 10.806
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Categoria #
all - tutte 52.746
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 52.746
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021752 0 0 0 0 0 46 69 77 107 203 160 90
2021/2022894 33 159 9 32 49 48 53 36 83 54 142 196
2022/20231.392 218 138 106 121 167 201 5 151 201 6 44 34
2023/2024805 35 94 19 41 41 86 147 275 3 11 6 47
2024/20252.072 78 35 147 71 64 189 193 199 90 106 288 612
2025/20262.187 610 224 445 381 445 82 0 0 0 0 0 0
Totale 12.164