IRIS
PIERNO, Sabata
 Distribuzione geografica
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Continente #
NA - Nord America 5.937
EU - Europa 1.107
AS - Asia 443
OC - Oceania 5
SA - Sud America 4
AF - Africa 2
Continente sconosciuto - Info sul continente non disponibili 2
Totale 7.500
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Nazione #
US - Stati Uniti d'America 5.926
CN - Cina 355
SE - Svezia 342
IT - Italia 192
UA - Ucraina 186
DE - Germania 118
FI - Finlandia 110
GB - Regno Unito 89
IN - India 34
FR - Francia 31
VN - Vietnam 27
BE - Belgio 17
IE - Irlanda 13
CA - Canada 11
IR - Iran 9
JP - Giappone 4
AU - Australia 3
CL - Cile 3
HK - Hong Kong 3
RU - Federazione Russa 3
TR - Turchia 3
EU - Europa 2
KR - Corea 2
MA - Marocco 2
NL - Olanda 2
NZ - Nuova Zelanda 2
AT - Austria 1
DK - Danimarca 1
EE - Estonia 1
ID - Indonesia 1
LA - Repubblica Popolare Democratica del Laos 1
NO - Norvegia 1
PH - Filippine 1
QA - Qatar 1
SG - Singapore 1
TH - Thailandia 1
VE - Venezuela 1
Totale 7.500
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Città #
Fairfield 829
Ashburn 747
Woodbridge 599
Chandler 536
Jacksonville 427
Houston 388
Seattle 325
Cambridge 308
Nyköping 285
Ann Arbor 277
Wilmington 252
Nanjing 114
Lawrence 109
Roxbury 109
Princeton 91
Bari 90
Inglewood 67
Des Moines 64
Beijing 62
Boardman 51
New York 40
San Diego 37
Nanchang 30
Hebei 28
Dong Ket 26
Jiaxing 25
Shenyang 22
Pune 21
Brussels 17
London 16
Falls Church 15
San Mateo 14
Dublin 13
Zhengzhou 13
Monmouth Junction 12
Changsha 11
Dearborn 11
Helsinki 11
Redwood City 11
Leawood 10
Tianjin 10
Ardabil 9
Augusta 9
Brooklyn 9
Genova 8
Ningbo 8
Hefei 7
Toronto 7
Jinan 6
Norwalk 6
Guangzhou 5
Indiana 5
Kilburn 5
Paris 5
Campobello Di Mazara 4
Islington 4
Montignoso 4
Ottawa 4
Sennori 4
Taranto 4
Trani 4
Chicago 3
Chiswick 3
Fuzhou 3
Kunming 3
Los Angeles 3
New Bedfont 3
Prescot 3
San Francisco 3
Santa Marinella 3
Washington 3
Altamura 2
Bollate 2
East Stroudsburg 2
Grafing 2
Haikou 2
Hong Kong 2
Hounslow 2
Ksar el Kbir 2
Lanzhou 2
Marseille 2
Mcallen 2
Melbourne 2
Milan 2
Padova 2
San Marzano Di San Giuseppe 2
Santiago 2
Simi Valley 2
Tappahannock 2
Tokyo 2
Torino 2
Vinovo 2
Aarhus 1
Acton 1
Agropoli 1
Auckland 1
Bangkok 1
Castelnuovo Rangone 1
Cattolica 1
Chions 1
Totale 6.320
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 411
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 134
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 118
Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles 114
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 110
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 109
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 107
The biophysical and pharmacological characteristics of skeletal muscle ATP-Sensitive K+ channels are modified in K+-depleted rat, an animal model of hypokalemic periodic paralysis 106
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 103
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 102
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 101
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 100
Redox homeostasis, oxidative stress and disuse muscle atrophy 99
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 99
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb unloaded mice 98
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 98
Fluvastatin and atorvastatin affect calcium homeostasis of rat skeletal muscle fibers in vivo and in vitro by impairing the sarcoplasmic reticulum/mitochondria Ca2+-release system 98
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 95
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 95
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 93
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 92
null 92
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 91
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 91
null 90
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 88
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 88
Taurine and skeletal muscle ion channels 87
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 87
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 86
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 86
null 86
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 82
Changes of chloride channel regulation in rat skeletal muscle during aging 82
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 81
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 80
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 79
Muscle loading modulates aquaporin-4 expression in skeletal muscle 78
Aging and chloride channel regulation in rat fast-twitch muscle fibres 76
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 74
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 74
Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle 74
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 73
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 72
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 71
Taurine and skeletal muscle disorders 69
null 69
Effects of chronic taurine treatment on the electrical and contractile properties of skeletal muscle fibers of aged rats 68
Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channels 68
null 68
Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation 67
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 67
Dual effects of taurine on membrane ionic conductances of rat skeletal muscle fibers 66
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 66
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 65
Experimental evaluation of the effects of pravastatin on electrophysiological parameters of rat skeletal muscle 65
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 64
Therapeutic approaches to ion channel diseases 64
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 64
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 63
Potential targets for skeletal muscle impairment by hypogravity: basic characterization of resting ionic conductances and mechanical threshold of rat fast- and slow-twitch muscle fibers 63
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 62
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 62
Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders 60
Growth hormone secretagogues exert differential effects on skeletal muscle calcium homeostasis in male rats depending on the peptidyl/non-peptidyl structure 59
Comparison of excitability parameters and sodium channel behavior of fast- and slow-twitch rat skeletal muscles for the study of the effects of hindlimb suspension, a model of hypogravity. 58
Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance 58
Changes in Expression and Cellular Localization of Rat Skeletal Muscle ClC-1 Chloride Channel in Relation to Age, Myofiber Phenotype and PKC Modulation 58
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 58
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers 57
null 56
Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle 55
null 55
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 51
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 51
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 51
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 51
EFFECTS OF TAURINE DEPLETION ON MEMBRANE ELECTIRCL PROPERTIES OF RAT SKELETAL MUSCLE. 50
Skeletal muscle disuse fiber type-dependent enhancement of Na+ channel expression 49
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 49
null 49
Higher content of insulin-like growth factor-1 in dystrophic mdx mouse: potential role in the spontaneous regeneration through an electrophysiological investigation of muscle function 48
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 47
Modification of resting chloride conductance during and after recovery from hindlimb unloading 43
Pharmacological interventions for the changes of chloride channel conductance of aging rat skeletal muscle 43
Farmaci per il trattamento delle malattie muscolari 41
Excitation-contraction coupling is altered in skeletal muscle of dystrophic mdx mouse 40
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 40
Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse 39
Role of tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach 39
Cyclic amidine analogs of taurine and homotaurine: synthesis and effects on rat skeletal muscle 39
Molecular mechanisms responsible for fluvastatin and fenofibrateinduced reduction of resting membrane chloride conductance in rat skeletal muscle 39
On ground preflight studies on skeletal muscle from mice kept in the Mouse Drawer System (MDS) 37
Stereoselective effects of a new analogs of clofibric acid on chloride channel conductance of rat skeletal muscle fibers 35
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function 35
Protein kinase C-dependent modulation of skeletal muscle resting chloride conductance is fiber type-specific and changes during rat hindlimb-unloading 33
Niflumic acid modulates the activity of the CLC-1 chloride channel and the calcium homeostasis of native rat skeletal muscle 33
Potential risk of myopathy by HMG-CoA reductase inhibitors: a comparison of pravastatin and simvastatin effects on membrane electrical properties of rat skeletal muscle fibers 33
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 31
Growth hormone administration to aged rats improves membrane electrical properties of skeletal muscle fibers 29
Totale 7.329
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Categoria #
all - tutte 29.561
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 29.561
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019617 0 0 0 0 0 0 0 0 0 120 245 252
2019/20201.912 324 112 58 181 200 115 209 168 239 102 149 55
2020/20211.269 144 74 83 115 106 46 68 76 106 201 160 90
2021/2022890 32 159 9 32 49 47 53 36 82 53 142 196
2022/20231.391 217 138 107 121 167 201 5 151 200 6 44 34
2023/2024743 35 94 19 42 41 86 147 275 3 1 0 0
Totale 7.786