IRIS
PIERNO, Sabata
 Distribuzione geografica
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Continente #
NA - Nord America 6.155
EU - Europa 1.455
AS - Asia 898
SA - Sud America 240
AF - Africa 10
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 2
Totale 8.765
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Nazione #
US - Stati Uniti d'America 6.127
CN - Cina 467
SE - Svezia 341
SG - Singapore 279
RU - Federazione Russa 230
BR - Brasile 215
IT - Italia 214
UA - Ucraina 190
DE - Germania 151
FI - Finlandia 117
GB - Regno Unito 98
FR - Francia 40
IN - India 34
ID - Indonesia 28
VN - Vietnam 27
BE - Belgio 23
CA - Canada 19
HK - Hong Kong 15
IE - Irlanda 13
CZ - Repubblica Ceca 10
IR - Iran 9
NL - Olanda 9
AT - Austria 8
AR - Argentina 7
MX - Messico 7
TR - Turchia 6
CL - Cile 5
IQ - Iraq 5
JP - Giappone 5
LT - Lituania 4
MA - Marocco 4
UZ - Uzbekistan 4
VE - Venezuela 4
AU - Australia 3
CI - Costa d'Avorio 3
PY - Paraguay 3
BD - Bangladesh 2
BO - Bolivia 2
DK - Danimarca 2
EC - Ecuador 2
EU - Europa 2
JO - Giordania 2
KG - Kirghizistan 2
KR - Corea 2
NP - Nepal 2
NZ - Nuova Zelanda 2
UY - Uruguay 2
AL - Albania 1
AM - Armenia 1
AZ - Azerbaigian 1
CR - Costa Rica 1
EE - Estonia 1
EG - Egitto 1
KE - Kenya 1
KH - Cambogia 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
NO - Norvegia 1
PA - Panama 1
PH - Filippine 1
PK - Pakistan 1
QA - Qatar 1
RO - Romania 1
RS - Serbia 1
SN - Senegal 1
TH - Thailandia 1
Totale 8.765
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Città #
Fairfield 841
Ashburn 758
Woodbridge 607
Chandler 536
Jacksonville 434
Houston 394
Seattle 330
Cambridge 310
Nyköping 284
Ann Arbor 278
Wilmington 255
Singapore 158
Nanjing 115
Lawrence 110
Roxbury 110
Bari 99
Princeton 91
Beijing 71
Inglewood 67
Boardman 63
Des Moines 63
New York 40
San Diego 37
Los Angeles 33
Nanchang 30
Hebei 29
Jiaxing 29
Jakarta 27
Dong Ket 26
Brussels 23
Shenyang 22
London 21
Pune 21
Helsinki 17
São Paulo 16
Falls Church 15
Guangzhou 15
Council Bluffs 14
Hong Kong 14
San Mateo 14
Toronto 14
Changsha 13
Dublin 13
Shanghai 13
Zhengzhou 13
Monmouth Junction 12
Moscow 12
Santa Clara 12
Dearborn 11
Redwood City 11
Brno 10
Leawood 10
Tianjin 10
Ardabil 9
Augusta 9
Brooklyn 9
Wuhan 9
Genova 8
Ningbo 8
Düsseldorf 7
Falkenstein 7
Hefei 7
Milan 7
Belo Horizonte 6
Jinan 6
Munich 6
Norwalk 6
Rio de Janeiro 6
Brasília 5
Frankfurt am Main 5
Indiana 5
Kilburn 5
Mexico City 5
Ottawa 5
Paris 5
Campobello Di Mazara 4
Islington 4
Jinhua 4
Montignoso 4
Natal 4
Nuremberg 4
Sennori 4
Taranto 4
Tashkent 4
The Dalles 4
Trani 4
Buenos Aires 3
Campo Grande 3
Chicago 3
Chiswick 3
Curitiba 3
Fuzhou 3
Kunming 3
New Bedfont 3
Phoenix 3
Prescot 3
San Francisco 3
Santa Marinella 3
Santiago 3
São José dos Campos 3
Totale 6.802
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 416
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 152
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 135
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 133
Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles 129
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 127
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 122
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 117
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 117
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 116
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 114
The biophysical and pharmacological characteristics of skeletal muscle ATP-Sensitive K+ channels are modified in K+-depleted rat, an animal model of hypokalemic periodic paralysis 112
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 111
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 110
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 107
Redox homeostasis, oxidative stress and disuse muscle atrophy 106
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 105
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 104
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 103
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 102
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 101
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb unloaded mice 101
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 101
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 101
null 100
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 99
Aging and chloride channel regulation in rat fast-twitch muscle fibres 96
Changes of chloride channel regulation in rat skeletal muscle during aging 95
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 94
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 94
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 94
null 93
Taurine and skeletal muscle ion channels 92
The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo 92
null 90
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 89
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 88
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 88
Muscle loading modulates aquaporin-4 expression in skeletal muscle 87
null 87
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 85
Changes in Expression and Cellular Localization of Rat Skeletal Muscle ClC-1 Chloride Channel in Relation to Age, Myofiber Phenotype and PKC Modulation 85
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 85
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 85
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 83
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 82
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 81
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 79
Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle 79
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 79
Taurine and skeletal muscle disorders 78
Dual effects of taurine on membrane ionic conductances of rat skeletal muscle fibers 77
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 77
Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation 75
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 74
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers 73
Effects of chronic growth hormone treatment in aged rats on the biophysical and pharmacological properties of skeletal muscle chloride channels 73
Effects of chronic taurine treatment on the electrical and contractile properties of skeletal muscle fibers of aged rats 72
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 72
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 72
null 70
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 69
Experimental evaluation of the effects of pravastatin on electrophysiological parameters of rat skeletal muscle 69
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 68
Potential targets for skeletal muscle impairment by hypogravity: basic characterization of resting ionic conductances and mechanical threshold of rat fast- and slow-twitch muscle fibers 68
null 68
Therapeutic approaches to ion channel diseases 67
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 67
Comparison of excitability parameters and sodium channel behavior of fast- and slow-twitch rat skeletal muscles for the study of the effects of hindlimb suspension, a model of hypogravity. 66
Therapeutic approaches to ion channel diseases 66
Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance 65
Growth hormone secretagogues exert differential effects on skeletal muscle calcium homeostasis in male rats depending on the peptidyl/non-peptidyl structure 64
Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders 64
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 63
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 62
Decrease in resting calcium and calcium entry associated with slow-to-fast transition in unloaded rat soleus muscle 61
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 59
Skeletal muscle disuse fiber type-dependent enhancement of Na+ channel expression 59
Taurine and skeletal muscle ion channels 58
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 58
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 58
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 57
null 57
EFFECTS OF TAURINE DEPLETION ON MEMBRANE ELECTIRCL PROPERTIES OF RAT SKELETAL MUSCLE. 57
Higher content of insulin-like growth factor-1 in dystrophic mdx mouse: potential role in the spontaneous regeneration through an electrophysiological investigation of muscle function 55
An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function 53
Increased sarcolemma chloride conductance as one of the mechanisms of action of carbonic anhydrase inhibitors in muscle excitability disorders 52
Pharmacological interventions for the changes of chloride channel conductance of aging rat skeletal muscle 51
Modification of resting chloride conductance during and after recovery from hindlimb unloading 50
null 49
Cyclic amidine analogs of taurine and homotaurine: synthesis and effects on rat skeletal muscle 47
Farmaci per il trattamento delle malattie muscolari 47
Excitation-contraction coupling is altered in skeletal muscle of dystrophic mdx mouse 46
Molecular mechanisms responsible for fluvastatin and fenofibrateinduced reduction of resting membrane chloride conductance in rat skeletal muscle 45
Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle 45
On ground preflight studies on skeletal muscle from mice kept in the Mouse Drawer System (MDS) 44
Role of tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach 44
Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse 43
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function 43
Stereoselective effects of a new analogs of clofibric acid on chloride channel conductance of rat skeletal muscle fibers 41
Totale 8.361
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Categoria #
all - tutte 40.943
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.943
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020206 0 0 0 0 0 0 0 0 0 0 150 56
2020/20211.279 145 75 84 116 107 46 69 77 107 203 160 90
2021/2022894 33 159 9 32 49 48 53 36 83 54 142 196
2022/20231.392 218 138 106 121 167 201 5 151 201 6 44 34
2023/2024805 35 94 19 41 41 86 147 275 3 11 6 47
2024/20251.190 78 35 147 71 64 189 193 199 90 106 18 0
Totale 9.095