IRIS
MARGIOTTA, NICOLA
 Distribuzione geografica
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Continente #
NA - Nord America 6.982
EU - Europa 1.903
AS - Asia 1.177
SA - Sud America 242
OC - Oceania 25
AF - Africa 13
Continente sconosciuto - Info sul continente non disponibili 2
Totale 10.344
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Nazione #
US - Stati Uniti d'America 6.961
CN - Cina 682
SE - Svezia 393
SG - Singapore 380
RU - Federazione Russa 320
UA - Ucraina 284
IT - Italia 245
DE - Germania 240
BR - Brasile 223
FI - Finlandia 170
GB - Regno Unito 101
FR - Francia 50
HK - Hong Kong 28
IE - Irlanda 26
AU - Australia 21
ID - Indonesia 20
BE - Belgio 19
IN - India 17
CA - Canada 16
NL - Olanda 13
TR - Turchia 10
AR - Argentina 8
AT - Austria 6
ES - Italia 6
IR - Iran 6
CZ - Repubblica Ceca 5
LT - Lituania 5
MA - Marocco 5
VN - Vietnam 5
BG - Bulgaria 4
HU - Ungheria 4
KR - Corea 4
NZ - Nuova Zelanda 4
PK - Pakistan 4
UZ - Uzbekistan 4
BD - Bangladesh 3
CO - Colombia 3
EC - Ecuador 3
KE - Kenya 3
KZ - Kazakistan 3
ZA - Sudafrica 3
EU - Europa 2
IQ - Iraq 2
JP - Giappone 2
MX - Messico 2
RS - Serbia 2
VE - Venezuela 2
AE - Emirati Arabi Uniti 1
AL - Albania 1
AM - Armenia 1
BO - Bolivia 1
CH - Svizzera 1
DK - Danimarca 1
EE - Estonia 1
EG - Egitto 1
GE - Georgia 1
HR - Croazia 1
IL - Israele 1
JM - Giamaica 1
JO - Giordania 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
ML - Mali 1
PA - Panama 1
PL - Polonia 1
PR - Porto Rico 1
PT - Portogallo 1
PY - Paraguay 1
RO - Romania 1
SI - Slovenia 1
SK - Slovacchia (Repubblica Slovacca) 1
UY - Uruguay 1
Totale 10.344
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Città #
Fairfield 983
Chandler 721
Jacksonville 671
Woodbridge 579
Ashburn 468
Houston 444
Seattle 395
Cambridge 382
Wilmington 327
Nyköping 311
Ann Arbor 233
Singapore 210
Nanjing 195
Lawrence 164
Roxbury 160
Boardman 122
Des Moines 105
Bari 94
New York 92
Beijing 85
Princeton 74
Nanchang 62
Brooklyn 41
San Diego 39
Shenyang 35
Inglewood 34
Santa Clara 32
Helsinki 31
Hebei 29
Dublin 26
Jiaxing 26
Dearborn 25
Hong Kong 24
London 24
Rome 23
Tianjin 22
Changsha 21
Moscow 21
Paris 21
Jakarta 20
Los Angeles 20
Brussels 19
São Paulo 18
Kunming 17
Guangzhou 15
San Francisco 15
Shanghai 15
Molfetta 14
Wuhan 13
Melbourne 12
Toronto 12
Auburn Hills 11
Zhengzhou 11
Jinan 10
Washington 10
Amsterdam 8
Leawood 8
Munich 8
Nuremberg 8
Arzano 7
Frankfurt am Main 7
Lauterbourg 7
Wuxi 7
Ningbo 6
Norwalk 6
San Mateo 6
Vienna 6
Ardabil 5
Augusta 5
Bologna 5
Falls Church 5
Hefei 5
Portsmouth 5
Pune 5
Taizhou 5
Budapest 4
Chicago 4
Düsseldorf 4
Joinville 4
Marseille 4
Noci 4
Porto Alegre 4
Redmond 4
Rio de Janeiro 4
Sydney 4
Tappahannock 4
Yiwu 4
Bogotá 3
Brno 3
Caldes de Montbui 3
Canberra 3
Edinburgh 3
Goiânia 3
Istanbul 3
Johannesburg 3
Lanzhou 3
Leeds 3
Magé 3
Monmouth Junction 3
Nairobi 3
Totale 7.794
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Nome #
Anticancer kiteplatin pyrophosphate derivatives show unexpected target selectivity for DNA 144
A Pt(IV) prodrug of kiteplatin with the bone-targeting pyrophosphate ligand 137
Bisphosphonate complexation and calcium doping in silica xerogels as a combined strategy for local and controlled release of active platinum antitumor compounds 124
A new case of polymorphism in platinum(II) complexes: [PtBr2(2,9-dimethyl-1,10-phenanthroline)]? 124
Addition versus substitution in the reaction of diiodo(2,9-dimethyl-1,10-phenanthroline)platinum(II) with aromatic bases. X-ray crystal structures of the substitution products with 2-amino-pyridine and 1-methyl-cytosine 123
Cytotoxicity-boosting of kiteplatin by Pt(IV) prodrugs with axial benzoate ligands 122
A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO) 115
Method of treating colorectal cancer. 115
Encapsulation of lipophilic kiteplatin Pt(IV) prodrugs in PLGA-PEG micelles 115
A new dinuclear platinum complex with a nitrogen-containing geminal bisphosphonate as potential anticancer compound specifically targeted to bone tissues 114
Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum-bisphosphonate complexes in the treatment of bone tumors: A mini-review 111
DNA fragment conformations in adducts with Kiteplatin 110
Dinuclear Pt(II)-bisphosphonate complexes: a scaffold for multinuclear or different oxidation state platinum drugs. 109
Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands 108
Hydroxyapatite nanocrystals as a smart, pH sensitive, delivery system for kiteplatin 106
Synthesis, Characterization, and Cytotoxicity of the First Oxaliplatin Pt(IV) Derivative Having a TSPO Ligand in the Axial Position 104
Insights into the role of the lead/surfactant ratio in the formation and passivation of cesium lead bromide perovskite nanocrystals 104
Cationic intermediates in oxidative addition reactions of Cl2 to [PtCl2(cis-1,4-DACH)] 100
Synthesis and Characterization of Platinum(II) Complexes of Diethyl [(Methylsulfinyl)methyl]phosphonate: Potential Drugs against Bone Tumors 99
Conformer distribution in (cis-1,4-DACH)bis(guanosine5'-phosphate)platinum(II) adducts: a reliable model for DNA adducts of antitumoral cisplatin 99
Reactivity of kiteplatin with S-donor biomolecules and nucleotides 98
Antitumor trans-platinum DNA adducts: NMR and HPLC study of the interaction between a trans-Pt(iminoether) complex and the deoxy decamer d(CCTCGCTCTC).d(GAGAGCGAGG) 98
Novel Therapeutic Agents for Bone Resorption. Part 1. Synthesis and Protonation Thermodynamics of Poly(amido-amine)s Containing Bis-phosphonate Residues 98
Novel Kiteplatin Pyrophosphate Derivatives with Improved Efficacy 97
Platinum Complexes with the Novel Ligand Diethyl [(Methylsulfinyl)- methyl]phosphonate (SMP): Solid-State Characterization of Potassium Trichloro(SMP)platinum(II) which, in Solution, Gives Dichloro(SMP)- platinum(II) and Potassium Chloride 96
Synthesis, characterization, and cytotoxicity of dinuclear platinum-bisphosphonate complexes to be used as prodrugs in the local treatment of bone tumours 95
Influence of carrier ligand NH hydrogen bonding to the O6 and phosphate group of Guanine nucleotides in Platinum complexes with a single guanine ligand 94
Unusual DNA Binding Properties of Chelate Ring-opening Platinum Complexes 93
Synthesis and characterization of a platinum(II) complex tethered to a ligand of the peripheral benzodiazepine receptor 92
Computational evidence for structural consequences of kiteplatin damage on DNA 92
Biomimetic hydroxyapatite/drug nanocrystals as potential bone substitutes with anti-tumour drug delivery properties 91
Antiviral properties and cytotoxic activity of platinum(II) complexes with 1,10-phenanthrolines and acyclovir or penciclovir 90
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Bisphosphonate complexation and calcium doping in silica xerogels as a combined strategy for local and controlled release of active platinum antitumor compounds. 87
Strong, Rapid Binding of a Platinum Complex to Thymine and Uracil Under Physiological Conditions 87
Role of metal ions and hydrogen bond acceptors in the tautomeric equilibrium of nitro-9[(alkylamino)amino]-acridine drugs 86
Influence of steric and electronic factors in the stabilization of five-coordinate ethylene complexes of platinum(II): X-ray crystal structure of [PtCl2(2,9-dimethyl-1,10-phenanthroline-5,6-dione)] 86
Mono- and bis-guanosine adducts of platinum complexes with carrier ligands having in-plane steric bulk: The case of 1,10-phenanthroline and 2,9-dimethyl-1,10-phenanthroline 86
Sterically hindered complexes of platinum(II) with planar heterocyclic nitrogen donors. A novel complex with 1-methyl-cytosine has a spectrum of activity different from cisplatin and is able of overcoming acquired cisplatin resistance 85
Synthesis, characterization, and in vitro cytotoxicity of a Kiteplatin-Ibuprofen Pt(IV) prodrug 85
Synthesis, characterization, and in vitro evaluation of a new TSPO-selective bifunctional chelate ligand 82
NMR investigation of the Spontaneous Thermal- and/or Photoinduced Reduction of trans Dihydroxido Pt(IV) Derivatives. 81
Multi-Acting Mitochondria-Targeted Platinum(IV) Prodrugs of Kiteplatin with α-Lipoic Acid in the Axial Positions 80
Metallo-drugs in the Treatment of Malignant Pleural Mesothelioma 79
Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates. 79
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Structure and dynamics of a Platinum(II) aminophosphine complex and its nucleobase adducts 78
Platinum(IV) complexes of trans-1,2-diamino-4-cyclohexene: Prodrugs affording an oxaliplatin analogue that overcomes cancer resistance 78
Revisiting [PtCl2(cis-1,4-DACH)]: An Underestimated Antitumor Drug with Potential Application to the Treatment of Oxaliplatin-Refractory Colorectal Cancer. 77
Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity 77
The influence of Carrier Ligand NH Hydrogen Bonding to the O6 and Phosphate Group of Guanine Nucleotides in Platinum Complexes with a Single Guanine Ligand 76
Smart delivery of antitumoral platinum complexes from biomimetic hydroxyapatite nanocrystals 76
One-Pot Synthesis of New Organometallic Compounds with Platinum-Carbon Bond 76
PEGylated solid lipid nanoparticles for brain delivery of lipophilic kiteplatin Pt(IV) prodrugs: An in vitro study 76
Dinuclear Pt(II)-bisphosphonates complexes: useful precursors of multinuclear or higher oxidation state platinum drugs. 74
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Cytotoxicity, cellular uptake, glutathione and DNA interactions of an antitumor large-ring PtII chelate complex incorporating the cis-1,4-diaminocyclohexane carrier ligand 74
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Antitumor trans iminoether platinum di- and oligonucleotide adducts studied by NMR. 71
Platinum(II) Complexes with Bioactive Carrier Ligands Having High Affinity for the Translocator Protein 70
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Activation of antitumoral platinum prodrugs for the local treatment of bone tumors by inclusion in bioactive inorganic matrices. 68
A novel Platinum(II) complex tethered to a ligand having high affinity for the Peripheral Benzodiazepine Receptor 68
Thermodynamic and mechanistic insights into translesion DNA synthesis catalyzed by Y-family DNA polymerase across a bulky double-base lesion of an antitumor platinum drug 68
9[(aminoalkyl)amino]nitroacridines: kinetic vs thermodynamic interactions towards platinum(II) and factors ruling their tautomeric equilibrium. 67
Platinum(II) Complexes with Antitumoral/Antiviral Aromatic Heterocycles: Effect of Glutathione upon in Vitro Cell Growth Inhibition 67
Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum(II) and rhenium(I) with a ligand targeting the translocator protein (TSPO) 67
Back to the future with Kiteplatin: an efficacious drug against oxaliplatin-refractory colorectal cancer. 65
A Molecular Tool for Measuring the Electron-Acceptor Ability of Ligands from Crystallographic Data 65
Recent findings in the chemistry of five-coordinate platinum(II) alkyne complexes. 64
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Selenium-doped hydroxyapatite nanoparticles for potential application in bone tumor therapy 64
Drug Targeting and Delivery of Platinum Chemotherapeutics ☆ 62
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Platinum–bisphosphonate complexes have proven to be inactive chemotherapeutics targeted for malignant mesothelioma because of inappropriate hydrolysis 59
Synthesis, characterization, and binding to the translocator protein (18 kDa, TSPO) of a new rhenium complex as a model of radiopharmaceutical agents. 59
Implementation of Sustainable Solvents in Green Polymerization Approaches 58
Assessing inter-nucleot(s)ide interactions by conformational studies of adducts between platinum complexes with carrier ligand unable to form H-bonds and guanine derivatives. 56
New Pt and Re complexes targeting the Translocator Protein 18 kDa (TSPO) as potential chemotherapics, radiopharmaceuticals, or theranostic agents 56
Dinuclear Pt(II)-bisphosphonate complexes:useful building blocks for the preparation of multinuclear or higher oxidation state platinum drugs. 55
Platinum-Based Antitumor Drugs Containing Enantiomerically Pure alpha-Trifluoromethyl Alanine as Ligand 54
Bioactive Inorganic Matrices for the Local Delivery of Platinum-based Prodrugs in the Treatment of Bone Tumors 53
Inclusion of Antitumoral platinum drugs in bioactive inorganic matrices to be used for the local treatment of bone tumors. 53
Antitumor drugs delivery by bone substitute biomimetic hydroxyapatite nanocrystals. 53
Monofunctional platinum(II) complexes and moleules of biological relevance: evaluation of steric and electronic factors in the competition for binding sites. 52
Calcium-modulated release of active platinum antitumor compounds from sol-gel silica xerogels. 51
Platinum-loaded, selenium-doped hydroxyapatite nanoparticles selectively reduce proliferation of prostate and breast cancer cells co-cultured in the presence of stem cells 51
A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring 50
Controlled release of platinum complexes from biomimetic hydroxyapatite nanocrystals. 49
H-Bond interactions between the NH of carrier ligand (Me3dien) and the O6 or the 5'-phosphate of guanine nucleotides in platinum complexes with a single guanine ligand. 49
TSPO-seeking Pt(II)- and Pt(IV)-complexes 48
Synthesis, characterization, and in vitro evaluation of a new TSPO-selective metal-chelating ligand 48
In vitro targeting and imaging the Translocator Protein TSPO 18-kDa through new coordination complexes of transition metals. 48
Slowing down dynamic motions in cisplatinum analogues. 48
The dynamic of metal chelate ring-opening: Pt(II) aminophosphine complexes and nucleotide adducts. 47
Penciclovir and Famcyclovir Pt(II) complexes. 47
Totale 7.983
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Categoria #
all - tutte 49.133
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 49.133
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020257 0 0 0 0 0 0 0 0 0 0 199 58
2020/20211.557 167 85 165 77 135 85 170 101 158 237 101 76
2021/20221.185 36 175 11 9 48 66 44 57 90 79 188 382
2022/20231.825 298 166 94 177 251 238 24 188 300 23 41 25
2023/2024579 58 110 26 54 77 142 15 5 15 12 4 61
2024/20251.462 98 39 221 83 106 174 240 208 104 173 16 0
Totale 10.670