A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new 99mTc or 188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac- [ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.

A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)

MARGIOTTA, NICOLA;DENORA, NUNZIO;;PACIFICO, Concetta;TRAPANI, Giuseppe;NATILE, Giovanni
2013

Abstract

A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new 99mTc or 188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac- [ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/127757
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