A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new 99mTc or 188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac- [ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.
A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)
MARGIOTTA, NICOLA;DENORA, NUNZIO;Iacobazzi RM;PACIFICO, Concetta;TRAPANI, Giuseppe;NATILE, Giovanni
2013-01-01
Abstract
A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new 99mTc or 188/186Re-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac- [ReBr(CO)3(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.File in questo prodotto:
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