IRIS
LEONETTI, Francesco
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 9.003
AS - Asia 3.021
EU - Europa 3.013
SA - Sud America 785
Continente sconosciuto - Info sul continente non disponibili 337
AF - Africa 120
OC - Oceania 3
AN - Antartide 1
Totale 16.283
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 8.820
SG - Singapore 1.199
IT - Italia 965
CN - Cina 794
BR - Brasile 636
DE - Germania 427
SE - Svezia 422
HK - Hong Kong 358
RU - Federazione Russa 316
VN - Vietnam 238
GB - Regno Unito 195
FR - Francia 186
FI - Finlandia 154
UA - Ucraina 147
IN - India 93
CA - Canada 90
BD - Bangladesh 69
ID - Indonesia 47
AR - Argentina 40
TR - Turchia 31
CO - Colombia 30
NL - Olanda 30
CI - Costa d'Avorio 29
IQ - Iraq 29
ZA - Sudafrica 25
IE - Irlanda 24
MX - Messico 24
BE - Belgio 23
JP - Giappone 22
EC - Ecuador 20
AT - Austria 18
ES - Italia 18
MA - Marocco 17
PK - Pakistan 17
PH - Filippine 16
PL - Polonia 16
UZ - Uzbekistan 15
CZ - Repubblica Ceca 14
PY - Paraguay 14
CL - Cile 13
SA - Arabia Saudita 13
VE - Venezuela 13
LT - Lituania 12
JO - Giordania 11
BO - Bolivia 10
JM - Giamaica 10
CR - Costa Rica 9
EG - Egitto 9
GT - Guatemala 9
MY - Malesia 9
TN - Tunisia 9
NI - Nicaragua 8
AZ - Azerbaigian 7
IR - Iran 7
CH - Svizzera 6
DZ - Algeria 6
HN - Honduras 6
KE - Kenya 6
RO - Romania 6
RS - Serbia 6
AE - Emirati Arabi Uniti 5
AL - Albania 5
ET - Etiopia 5
KG - Kirghizistan 5
KZ - Kazakistan 5
PR - Porto Rico 5
SV - El Salvador 5
UY - Uruguay 5
IL - Israele 4
TT - Trinidad e Tobago 4
AO - Angola 3
CW - ???statistics.table.value.countryCode.CW??? 3
DO - Repubblica Dominicana 3
EU - Europa 3
HU - Ungheria 3
KR - Corea 3
NG - Nigeria 3
NP - Nepal 3
OM - Oman 3
PE - Perù 3
PS - Palestinian Territory 3
SY - Repubblica araba siriana 3
TW - Taiwan 3
AU - Australia 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BH - Bahrain 2
DK - Danimarca 2
EE - Estonia 2
GD - Grenada 2
GE - Georgia 2
GP - Guadalupe 2
LV - Lettonia 2
PA - Panama 2
PT - Portogallo 2
SC - Seychelles 2
SN - Senegal 2
TH - Thailandia 2
AD - Andorra 1
AM - Armenia 1
Totale 15.932
Salva come PNG Salva come JPEG
Città #
Dallas 983
Ashburn 866
Fairfield 746
Singapore 664
San Jose 563
Chandler 544
Woodbridge 445
Houston 354
Hong Kong 352
Jacksonville 323
Seattle 319
Milan 301
Nyköping 295
Cambridge 268
Beijing 259
Wilmington 241
Ann Arbor 213
Council Bluffs 183
Bari 167
Los Angeles 108
Nanjing 105
Roxbury 105
Lauterbourg 104
Lawrence 103
New York 101
Rome 89
Boardman 88
Washington 73
Munich 72
Ho Chi Minh City 70
Helsinki 66
Santa Clara 65
São Paulo 63
Des Moines 61
Brooklyn 59
Princeton 51
Columbus 44
Hanoi 44
Dearborn 43
Falkenstein 38
Buffalo 37
London 37
Dong Ket 36
Atlanta 35
Nanchang 32
Figino 31
Abidjan 29
Jakarta 29
North Bergen 29
San Diego 28
Shenyang 28
Chicago 27
Hebei 27
Inglewood 27
Frankfurt am Main 26
Dublin 24
Jiaxing 24
Toronto 24
Brussels 23
Turin 23
Boydton 21
Rio de Janeiro 21
Nuremberg 20
Orem 20
Phoenix 19
Tokyo 19
Amsterdam 17
Guangzhou 17
Marseille 17
Montreal 17
Triggiano 17
Moscow 16
Naples 16
Belo Horizonte 15
Kansas City 15
Paris 15
Boston 14
Brasília 14
Campinas 14
Denver 14
Florence 14
Tashkent 14
Tianjin 14
Baghdad 13
Johannesburg 13
Porto Alegre 13
Pune 13
Curitiba 12
The Dalles 12
Warsaw 12
Amman 11
Poplar 11
Santiago 11
Shanghai 11
Taranto 11
Bogotá 10
Changsha 10
Jinan 10
New Delhi 10
Salvador 10
Totale 10.787
Salva come PNG Salva come JPEG
Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.101
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 274
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 232
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 218
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 216
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 215
CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer 203
Mind the Gap ! A Journey towards Computational Toxicology 201
Ion channels in drug discovery and safety pharmacology 195
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 190
An updated patent review on P-glycoprotein inhibitors (2011-2018) 189
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 189
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 188
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 184
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 183
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 182
A Multi-Objective Optimization Algorithm for Molecular Design 179
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 174
Molecular docking for predictive toxicology 174
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 173
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 170
Attenuation of autoimmune disease in fas-deficient mice by treatment with a cytotoxic benzodiazepine 164
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 163
A multitarget approach in cancer research 162
Strategies to improve cancer immune checkpoint inhibitors efficacy, other than abscopal effect: A systematic review 160
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 154
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 154
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 151
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 150
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 150
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 150
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 147
Strategies of Virtual Screening in Medicinal Chemistry 144
TSPO-targeted NIR-fluorescent ultra-small iron oxide nanoparticles for glioblastoma imaging 143
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 142
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 139
Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on Mitsunobu reaction 138
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 138
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 138
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 136
Estimation of the Binding Free Energy by Linear Interaction Energy Models 135
Molecular characterization of a long-term survivor double metastatic non-small cell lung cancer and pancreatic ductal adenocarcinoma treated with gefitinib in combination with gemcitabine plus nab-paclitaxel and mFOLFOX6 as first and second line therapy 134
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 134
2-D and 3-D modeling of imadazoline receptor ligands: insights into pharmacophore 133
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 132
Structure Activity Studies of a Novel Cytotoxic Benzodiazepine 130
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin 130
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models. 130
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 129
Design, Synthesis, and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors 129
Lipophilicity in Molecular Modeling of MAO Inhibitors. 128
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 128
TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity 127
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries 125
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 124
Strategies of multi-objective optimization in drug discovery and development 123
A new approach to combine ligand- and structure-based drug design. 122
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 121
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 121
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility 120
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 120
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 119
Computational methods for the design of potent aromatase inhibitors 119
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 119
Microfluidic-assisted preparation of targeted ph-responsive polymeric micelles improves gemcitabine effectiveness in pdac: In vitro insights 118
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 117
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 116
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 116
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 116
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 116
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug. 113
Positional Scanning Libraries of Fluorogenic Substrates for Determining Protease Specificity, Incorporating P1 Diversity. 112
A novel function for non-deterministic scouting of optimal QSAR models out of a highly-structured physicochemical space. 111
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 110
Fast and Reliable Electronic Assay of a Xylella fastidiosa Single Bacterium in Infected Plants Sap 108
Development of purified glycogen derivatives as siRNA nanovectors 108
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 106
Inflammatory Related Reactions in Humans and in Canine Breast Cancers, A Spontaneous Animal Model of Disease 106
An integrated methodology to interface structure- and ligand-based drug design 105
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 105
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 104
Modeling of MAO-A/MAO-B Inhibitory Activity and Selectivity: 2D- and 3D-QSAR Studies. 103
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities 103
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 101
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 101
Synthesis and Monoamine Oxidase Inhibitory Activity of new Pyridazine-, Pyrimidine and 1,2,4 Triazine containing Tryciclic derivatives 100
Structure-Based Design, Solid Phase Synthesis and SAFIR of New Dual Binding Site Acetylcholinesterase (AChE) Inhibitors. 98
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 98
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 97
Binding of tracizolines to the imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 97
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 96
Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self-Assembled Monolayers 94
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs 93
Insights into Diastereospecific Solvolysis of Peptidyl-β-Lactams: Combined Kinetic and Conformational Studies. 93
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 93
Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal 92
Screening of matrix metalloproteinases available from the protein data bank: Insights into biological functions, domain organization, and zinc binding groups 91
Peptide-aminomethylcoumarin Positional Scanning Libraries for Determining Protease Specificity, Incorporating P1 Diversity 89
Cannabinoid receptor subtype 2 (CB2R): Features and targets for medical applications 85
New peptidyl-β-lactams: solution-solid phase synthesis for the preparation of antibiotic libraries. 85
Totale 14.581
Salva come PNG Salva come JPEG
Categoria #
all - tutte 60.773
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.773
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022690 0 0 0 20 40 50 54 36 62 107 118 203
2022/20231.439 219 144 95 123 179 170 21 180 236 12 31 29
2023/2024640 34 89 26 110 53 109 24 14 21 45 26 89
2024/20252.253 65 55 190 97 82 154 264 190 112 99 290 655
2025/20265.431 631 381 1.015 475 462 248 508 147 433 421 186 524
2026/20271.345 139 207 402 597 0 0 0 0 0 0 0 0
Totale 16.283