IRIS
LEONETTI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 6.963
AS - Asia 2.565
EU - Europa 2.146
SA - Sud America 607
AF - Africa 74
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 3
AN - Antartide 1
Totale 12.362
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Nazione #
US - Stati Uniti d'America 6.891
SG - Singapore 1.076
CN - Cina 722
BR - Brasile 545
SE - Svezia 421
DE - Germania 402
IT - Italia 362
HK - Hong Kong 341
RU - Federazione Russa 306
VN - Vietnam 205
GB - Regno Unito 163
UA - Ucraina 143
FI - Finlandia 123
FR - Francia 74
IN - India 47
CA - Canada 42
ID - Indonesia 37
CI - Costa d'Avorio 29
IE - Irlanda 22
IQ - Iraq 22
NL - Olanda 22
BD - Bangladesh 21
BE - Belgio 21
AR - Argentina 20
TR - Turchia 19
AT - Austria 16
MX - Messico 15
CZ - Repubblica Ceca 13
JP - Giappone 13
PL - Polonia 13
ZA - Sudafrica 13
EC - Ecuador 11
ES - Italia 11
MA - Marocco 8
PY - Paraguay 8
CO - Colombia 7
IR - Iran 7
JO - Giordania 7
LT - Lituania 7
VE - Venezuela 7
DZ - Algeria 5
PK - Pakistan 5
RO - Romania 5
UZ - Uzbekistan 5
AE - Emirati Arabi Uniti 4
AL - Albania 4
CL - Cile 4
GT - Guatemala 4
SA - Arabia Saudita 4
TN - Tunisia 4
AO - Angola 3
CH - Svizzera 3
EG - Egitto 3
EU - Europa 3
IL - Israele 3
JM - Giamaica 3
KG - Kirghizistan 3
KZ - Kazakistan 3
NG - Nigeria 3
RS - Serbia 3
TW - Taiwan 3
AU - Australia 2
AZ - Azerbaigian 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BH - Bahrain 2
BO - Bolivia 2
CR - Costa Rica 2
ET - Etiopia 2
GD - Grenada 2
KE - Kenya 2
KR - Corea 2
MY - Malesia 2
OM - Oman 2
PS - Palestinian Territory 2
SY - Repubblica araba siriana 2
UY - Uruguay 2
AD - Andorra 1
AQ - Antartide 1
CD - Congo 1
DO - Repubblica Dominicana 1
EE - Estonia 1
GE - Georgia 1
GI - Gibilterra 1
GP - Guadalupe 1
GR - Grecia 1
HN - Honduras 1
HR - Croazia 1
LK - Sri Lanka 1
LV - Lettonia 1
MK - Macedonia 1
NP - Nepal 1
NZ - Nuova Zelanda 1
PE - Perù 1
PH - Filippine 1
PR - Porto Rico 1
PT - Portogallo 1
SN - Senegal 1
Totale 12.362
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Città #
Dallas 967
Fairfield 746
Singapore 573
Ashburn 572
Chandler 543
Woodbridge 445
Houston 352
Hong Kong 335
Jacksonville 322
Seattle 318
Nyköping 295
Cambridge 268
Beijing 249
Wilmington 240
Ann Arbor 213
Bari 162
Nanjing 105
Roxbury 105
Lawrence 103
New York 79
Los Angeles 75
Munich 72
Boardman 70
Ho Chi Minh City 61
Des Moines 59
Brooklyn 53
Princeton 51
Dearborn 43
São Paulo 43
Hanoi 39
Dong Ket 36
Helsinki 35
Nanchang 32
Santa Clara 31
London 30
Abidjan 29
Buffalo 29
Hebei 27
Inglewood 27
Jakarta 27
San Diego 26
Shenyang 26
Falkenstein 25
North Bergen 25
Jiaxing 23
Dublin 22
Brussels 21
Boydton 20
Rio de Janeiro 20
Council Bluffs 19
Nuremberg 19
Frankfurt am Main 17
Milan 17
Triggiano 17
Guangzhou 16
Toronto 16
Atlanta 15
Marseille 15
Moscow 15
Amsterdam 14
Belo Horizonte 14
Paris 14
Tianjin 14
Chicago 13
Columbus 13
Kansas City 13
Tokyo 13
Boston 12
Orem 12
Porto Alegre 12
Pune 12
San Jose 12
The Dalles 12
Washington 12
Campinas 11
Florence 11
Poplar 11
Rome 11
Brasília 10
Changsha 10
Jinan 10
Shanghai 10
Stockholm 10
Warsaw 10
Curitiba 9
Denver 9
Falls Church 9
Johannesburg 9
Salvador 9
Da Nang 8
Montreal 8
Redwood City 8
San Mateo 8
Turku 8
Amman 7
Augusta 7
Baghdad 7
Brno 7
Norwalk 7
Phoenix 7
Totale 8.658
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.054
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 225
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 186
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 186
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 185
Mind the Gap ! A Journey towards Computational Toxicology 176
Ion channels in drug discovery and safety pharmacology 166
An updated patent review on P-glycoprotein inhibitors (2011-2018) 166
CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer 161
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 161
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 160
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 155
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 146
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 146
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 144
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 143
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 142
Molecular docking for predictive toxicology 141
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 138
Strategies to improve cancer immune checkpoint inhibitors efficacy, other than abscopal effect: A systematic review 138
Attenuation of autoimmune disease in fas-deficient mice by treatment with a cytotoxic benzodiazepine 136
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 134
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 129
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 128
Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on Mitsunobu reaction 127
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 125
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 122
A multitarget approach in cancer research 121
A Multi-Objective Optimization Algorithm for Molecular Design 121
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 121
Strategies of Virtual Screening in Medicinal Chemistry 119
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 118
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 116
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 115
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 112
Design, Synthesis, and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors 111
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models. 111
TSPO-targeted NIR-fluorescent ultra-small iron oxide nanoparticles for glioblastoma imaging 110
Structure Activity Studies of a Novel Cytotoxic Benzodiazepine 108
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 108
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 108
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 107
Molecular characterization of a long-term survivor double metastatic non-small cell lung cancer and pancreatic ductal adenocarcinoma treated with gefitinib in combination with gemcitabine plus nab-paclitaxel and mFOLFOX6 as first and second line therapy 106
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin 105
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 103
Estimation of the Binding Free Energy by Linear Interaction Energy Models 103
Computational methods for the design of potent aromatase inhibitors 103
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 101
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 100
2-D and 3-D modeling of imadazoline receptor ligands: insights into pharmacophore 100
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug. 99
Lipophilicity in Molecular Modeling of MAO Inhibitors. 99
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility 98
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries 97
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 96
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 96
A new approach to combine ligand- and structure-based drug design. 95
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 95
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 94
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 93
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 93
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 91
TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity 88
Positional Scanning Libraries of Fluorogenic Substrates for Determining Protease Specificity, Incorporating P1 Diversity. 88
Strategies of multi-objective optimization in drug discovery and development 88
A novel function for non-deterministic scouting of optimal QSAR models out of a highly-structured physicochemical space. 87
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 86
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 85
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 84
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities 84
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 84
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 83
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 82
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 82
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 82
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 80
Development of purified glycogen derivatives as siRNA nanovectors 80
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 79
Structure-Based Design, Solid Phase Synthesis and SAFIR of New Dual Binding Site Acetylcholinesterase (AChE) Inhibitors. 78
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 77
Modeling of MAO-A/MAO-B Inhibitory Activity and Selectivity: 2D- and 3D-QSAR Studies. 77
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 77
Screening of matrix metalloproteinases available from the protein data bank: Insights into biological functions, domain organization, and zinc binding groups 77
An integrated methodology to interface structure- and ligand-based drug design 76
Insights into Diastereospecific Solvolysis of Peptidyl-β-Lactams: Combined Kinetic and Conformational Studies. 74
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 72
Binding of tracizolines to the imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 71
Microfluidic-assisted preparation of targeted ph-responsive polymeric micelles improves gemcitabine effectiveness in pdac: In vitro insights 71
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 70
Sintesi su Fase Solida della Safinamide e di suoi Analoghi. 70
Fast and Reliable Electronic Assay of a Xylella fastidiosa Single Bacterium in Infected Plants Sap 69
Inflammatory Related Reactions in Humans and in Canine Breast Cancers, A Spontaneous Animal Model of Disease 68
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug 67
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 67
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 66
Fast and highly efficient one-pot synthesis of 9-deazaxanthines 66
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 65
null 63
Peptide-aminomethylcoumarin Positional Scanning Libraries for Determining Protease Specificity, Incorporating P1 Diversity 62
Synthesis and Monoamine Oxidase Inhibitory Activity of new Pyridazine-, Pyrimidine and 1,2,4 Triazine containing Tryciclic derivatives 62
Totale 11.580
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Categoria #
all - tutte 49.684
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 49.684
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021595 0 0 0 0 0 57 52 65 82 170 83 86
2021/2022863 59 103 11 20 40 50 54 36 62 107 118 203
2022/20231.439 219 144 95 123 179 170 21 180 236 12 31 29
2023/2024640 34 89 26 110 53 109 24 14 21 45 26 89
2024/20252.253 65 55 190 97 82 154 264 190 112 99 290 655
2025/20263.174 631 381 1.015 475 462 210 0 0 0 0 0 0
Totale 12.681