IRIS
LEONETTI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 5.190
EU - Europa 1.593
AS - Asia 821
SA - Sud America 12
AF - Africa 4
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 2
Totale 7.625
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Nazione #
US - Stati Uniti d'America 5.179
CN - Cina 483
SE - Svezia 410
DE - Germania 295
IT - Italia 294
SG - Singapore 229
UA - Ucraina 139
RU - Federazione Russa 129
GB - Regno Unito 107
FI - Finlandia 106
FR - Francia 41
VN - Vietnam 38
ID - Indonesia 23
IN - India 23
IE - Irlanda 21
BE - Belgio 18
CZ - Repubblica Ceca 11
CA - Canada 10
BR - Brasile 8
NL - Olanda 7
IR - Iran 6
HK - Hong Kong 5
CO - Colombia 3
EU - Europa 3
JO - Giordania 3
JP - Giappone 3
LT - Lituania 3
AT - Austria 2
BG - Bulgaria 2
CH - Svizzera 2
DZ - Algeria 2
ES - Italia 2
IQ - Iraq 2
NG - Nigeria 2
RS - Serbia 2
AD - Andorra 1
AE - Emirati Arabi Uniti 1
AR - Argentina 1
AU - Australia 1
BD - Bangladesh 1
LK - Sri Lanka 1
MX - Messico 1
MY - Malesia 1
NZ - Nuova Zelanda 1
PK - Pakistan 1
PT - Portogallo 1
TR - Turchia 1
Totale 7.625
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Città #
Fairfield 746
Chandler 543
Woodbridge 445
Ashburn 361
Houston 350
Jacksonville 322
Seattle 313
Nyköping 295
Cambridge 268
Wilmington 239
Ann Arbor 212
Singapore 186
Bari 140
Nanjing 105
Roxbury 105
Lawrence 103
Beijing 91
Boardman 70
Des Moines 59
New York 51
Princeton 51
Dearborn 43
Brooklyn 40
Dong Ket 36
Nanchang 32
Hebei 27
Helsinki 27
Inglewood 27
San Diego 26
Shenyang 25
Jakarta 23
Jiaxing 23
Los Angeles 22
Dublin 21
Boydton 20
Munich 19
Santa Clara 19
Brussels 18
Triggiano 17
Guangzhou 16
London 16
Milan 16
Marseille 15
Paris 14
Tianjin 14
Kansas City 13
Washington 12
Pune 11
Changsha 10
Jinan 10
Shanghai 10
Falls Church 9
Redwood City 8
San Mateo 8
Brno 7
Norwalk 7
Rome 7
Toronto 7
Zhengzhou 7
Ardabil 6
Hefei 6
Amsterdam 5
Auburn Hills 5
Augusta 5
Frankfurt am Main 5
Leawood 5
Wuhan 5
Hong Kong 4
Hounslow 4
Kilburn 4
Kunming 4
Mumbai 4
Nuremberg 4
Prescot 4
Strasbourg 4
Taranto 4
West Jordan 4
Yiwu 4
Amman 3
Fano 3
Grafing 3
Ningbo 3
Noicattaro 3
Romola 3
Taizhou 3
Terlizzi 3
Tokyo 3
Belgrade 2
Bitonto 2
Carmignano 2
Casoria 2
Cava De' Tirreni 2
Chongqing 2
Cosenza 2
Dalian 2
Falkenstein 2
Grottaglie 2
Hanoi 2
Jinhua 2
Lagos 2
Totale 5.876
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 221
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 157
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 138
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 133
Ion channels in drug discovery and safety pharmacology 133
Mind the Gap ! A Journey towards Computational Toxicology 128
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 128
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 124
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 118
Molecular docking for predictive toxicology 116
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 114
An updated patent review on P-glycoprotein inhibitors (2011-2018) 114
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 114
Strategies to improve cancer immune checkpoint inhibitors efficacy, other than abscopal effect: A systematic review 112
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 111
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 106
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 106
CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer 101
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 100
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 100
Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on Mitsunobu reaction 99
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 95
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 94
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 93
Strategies of Virtual Screening in Medicinal Chemistry 91
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility 89
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 88
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 86
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 85
Structure Activity Studies of a Novel Cytotoxic Benzodiazepine 83
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug. 83
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin 83
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 83
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 81
TSPO-targeted NIR-fluorescent ultra-small iron oxide nanoparticles for glioblastoma imaging 81
Design, Synthesis, and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors 79
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 79
Attenuation of autoimmune disease in fas-deficient mice by treatment with a cytotoxic benzodiazepine 79
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 77
Molecular characterization of a long-term survivor double metastatic non-small cell lung cancer and pancreatic ductal adenocarcinoma treated with gefitinib in combination with gemcitabine plus nab-paclitaxel and mFOLFOX6 as first and second line therapy 77
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 77
Lipophilicity in Molecular Modeling of MAO Inhibitors. 76
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 75
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models. 75
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 75
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 74
A multitarget approach in cancer research 73
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 73
Strategies of multi-objective optimization in drug discovery and development 72
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 72
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 72
Positional Scanning Libraries of Fluorogenic Substrates for Determining Protease Specificity, Incorporating P1 Diversity. 71
Estimation of the Binding Free Energy by Linear Interaction Energy Models 70
Computational methods for the design of potent aromatase inhibitors 70
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 69
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities 69
Modeling of MAO-A/MAO-B Inhibitory Activity and Selectivity: 2D- and 3D-QSAR Studies. 65
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 65
A Multi-Objective Optimization Algorithm for Molecular Design 64
Structure-Based Design, Solid Phase Synthesis and SAFIR of New Dual Binding Site Acetylcholinesterase (AChE) Inhibitors. 63
A new approach to combine ligand- and structure-based drug design. 63
null 63
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 63
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries 63
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 63
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 63
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 61
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 60
Insights into Diastereospecific Solvolysis of Peptidyl-β-Lactams: Combined Kinetic and Conformational Studies. 59
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 57
A novel function for non-deterministic scouting of optimal QSAR models out of a highly-structured physicochemical space. 56
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 55
Sintesi su Fase Solida della Safinamide e di suoi Analoghi. 53
Fast and highly efficient one-pot synthesis of 9-deazaxanthines 53
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 52
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 52
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug 51
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 51
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 51
Binding of tracizolines to the imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 49
Screening of matrix metalloproteinases available from the protein data bank: Insights into biological functions, domain organization, and zinc binding groups 49
An integrated methodology to interface structure- and ligand-based drug design 48
2-D and 3-D modeling of imadazoline receptor ligands: insights into pharmacophore 48
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 47
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 47
New peptidyl-beta-lactams: solution-solid phase synthesis for the preparation of antibiotic libraries 46
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 45
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 45
New peptidyl-β-lactams: solution-solid phase synthesis for the preparation of antibiotic libraries. 43
Synthesis and Monoamine Oxidase Inhibitory Activity of new Pyridazine-, Pyrimidine and 1,2,4 Triazine containing Tryciclic derivatives 43
Solid phase synthesis of potential PKs inhibitors 42
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 41
Peptide-aminomethylcoumarin Positional Scanning Libraries for Determining Protease Specificity, Incorporating P1 Diversity 40
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 39
Microfluidic-assisted preparation of targeted ph-responsive polymeric micelles improves gemcitabine effectiveness in pdac: In vitro insights 39
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) 38
Positional Scanning Libraries of Fluorogenic Peptide Substrates for Determining Protease Specificity. 36
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 33
Development of purified glycogen derivatives as siRNA nanovectors 33
Lc-Ms Oxycodone Study: Its Stability in Anapa Devices 31
Totale 7.570
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Categoria #
all - tutte 33.704
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.704
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020900 0 0 0 0 0 0 200 176 233 103 146 42
2020/20211.102 111 73 67 150 106 57 52 65 82 170 83 86
2021/2022863 59 103 11 20 40 50 54 36 62 107 118 203
2022/20231.439 219 144 95 123 179 170 21 180 236 12 31 29
2023/2024640 34 89 26 110 53 109 24 14 21 45 26 89
2024/2025675 65 55 190 97 82 154 32 0 0 0 0 0
Totale 7.929