IRIS
LEONETTI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 7.642
AS - Asia 2.951
EU - Europa 2.406
SA - Sud America 748
AF - Africa 116
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 3
AN - Antartide 1
Totale 13.870
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Nazione #
US - Stati Uniti d'America 7.552
SG - Singapore 1.186
CN - Cina 777
BR - Brasile 613
DE - Germania 426
SE - Svezia 422
IT - Italia 404
HK - Hong Kong 355
RU - Federazione Russa 313
VN - Vietnam 237
FR - Francia 182
GB - Regno Unito 176
FI - Finlandia 154
UA - Ucraina 147
IN - India 91
CA - Canada 48
ID - Indonesia 46
BD - Bangladesh 41
AR - Argentina 39
TR - Turchia 31
CI - Costa d'Avorio 29
IQ - Iraq 29
NL - Olanda 27
IE - Irlanda 24
ZA - Sudafrica 24
BE - Belgio 22
JP - Giappone 22
MX - Messico 22
CO - Colombia 21
EC - Ecuador 20
AT - Austria 17
MA - Marocco 17
PK - Pakistan 17
ES - Italia 15
PL - Polonia 15
UZ - Uzbekistan 15
CZ - Repubblica Ceca 14
PY - Paraguay 14
CL - Cile 13
PH - Filippine 13
SA - Arabia Saudita 12
JO - Giordania 11
BO - Bolivia 10
LT - Lituania 10
MY - Malesia 9
TN - Tunisia 9
VE - Venezuela 9
EG - Egitto 8
AZ - Azerbaigian 7
IR - Iran 7
DZ - Algeria 6
KE - Kenya 6
RO - Romania 6
AE - Emirati Arabi Uniti 5
AL - Albania 5
ET - Etiopia 5
KG - Kirghizistan 5
UY - Uruguay 5
CH - Svizzera 4
GT - Guatemala 4
IL - Israele 4
JM - Giamaica 4
KZ - Kazakistan 4
RS - Serbia 4
AO - Angola 3
EU - Europa 3
HU - Ungheria 3
KR - Corea 3
NG - Nigeria 3
NP - Nepal 3
OM - Oman 3
PE - Perù 3
PS - Palestinian Territory 3
SY - Repubblica araba siriana 3
TW - Taiwan 3
AU - Australia 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BH - Bahrain 2
CR - Costa Rica 2
DO - Repubblica Dominicana 2
GD - Grenada 2
GE - Georgia 2
LV - Lettonia 2
PA - Panama 2
SN - Senegal 2
TH - Thailandia 2
AD - Andorra 1
AM - Armenia 1
AQ - Antartide 1
CD - Congo 1
DK - Danimarca 1
EE - Estonia 1
GI - Gibilterra 1
GN - Guinea 1
GP - Guadalupe 1
GR - Grecia 1
HN - Honduras 1
HR - Croazia 1
LB - Libano 1
Totale 13.859
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Città #
Dallas 971
Fairfield 746
Singapore 662
Ashburn 643
Chandler 543
Woodbridge 445
San Jose 387
Houston 352
Hong Kong 349
Jacksonville 322
Seattle 319
Nyköping 295
Cambridge 268
Beijing 252
Wilmington 240
Ann Arbor 213
Bari 162
Nanjing 105
Roxbury 105
Lauterbourg 104
Lawrence 103
Los Angeles 84
New York 83
Munich 72
Boardman 70
Ho Chi Minh City 70
Helsinki 66
Des Moines 61
Brooklyn 55
Princeton 51
São Paulo 51
Council Bluffs 46
Hanoi 44
Dearborn 43
Santa Clara 40
Falkenstein 38
Dong Ket 36
London 33
Nanchang 32
Buffalo 31
Abidjan 29
Jakarta 29
Shenyang 28
Hebei 27
Inglewood 27
Frankfurt am Main 26
San Diego 26
North Bergen 25
Dublin 24
Jiaxing 24
Brussels 22
Rio de Janeiro 21
Boydton 20
Nuremberg 20
Orem 20
Atlanta 19
Tokyo 19
Amsterdam 17
Guangzhou 17
Marseille 17
Milan 17
Triggiano 17
Moscow 16
Toronto 16
Belo Horizonte 15
Chicago 15
Paris 15
Boston 14
Columbus 14
Tashkent 14
Tianjin 14
Baghdad 13
Campinas 13
Johannesburg 13
Kansas City 13
Porto Alegre 13
Pune 13
Curitiba 12
The Dalles 12
Washington 12
Amman 11
Brasília 11
Denver 11
Florence 11
Montreal 11
Poplar 11
Rome 11
Santiago 11
Shanghai 11
Warsaw 11
Changsha 10
Jinan 10
New Delhi 10
Salvador 10
Stockholm 10
Chennai 9
Da Nang 9
Falls Church 9
Phoenix 9
Redwood City 8
Totale 9.534
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.073
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 248
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 203
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 202
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 201
Mind the Gap ! A Journey towards Computational Toxicology 191
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 182
An updated patent review on P-glycoprotein inhibitors (2011-2018) 181
CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer 176
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 174
Ion channels in drug discovery and safety pharmacology 172
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 167
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 163
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 161
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 159
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 157
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 157
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 156
Molecular docking for predictive toxicology 154
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 150
Strategies to improve cancer immune checkpoint inhibitors efficacy, other than abscopal effect: A systematic review 149
Attenuation of autoimmune disease in fas-deficient mice by treatment with a cytotoxic benzodiazepine 148
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 146
A multitarget approach in cancer research 139
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 139
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 137
A Multi-Objective Optimization Algorithm for Molecular Design 136
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 135
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 134
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 133
Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on Mitsunobu reaction 133
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 131
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 131
Strategies of Virtual Screening in Medicinal Chemistry 128
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 127
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 126
Design, Synthesis, and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors 121
Molecular characterization of a long-term survivor double metastatic non-small cell lung cancer and pancreatic ductal adenocarcinoma treated with gefitinib in combination with gemcitabine plus nab-paclitaxel and mFOLFOX6 as first and second line therapy 121
TSPO-targeted NIR-fluorescent ultra-small iron oxide nanoparticles for glioblastoma imaging 121
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 120
Structure Activity Studies of a Novel Cytotoxic Benzodiazepine 117
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 116
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models. 116
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 114
2-D and 3-D modeling of imadazoline receptor ligands: insights into pharmacophore 113
Strategies of multi-objective optimization in drug discovery and development 112
Estimation of the Binding Free Energy by Linear Interaction Energy Models 111
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 111
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 110
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin 109
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 109
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 108
A new approach to combine ligand- and structure-based drug design. 108
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 108
Computational methods for the design of potent aromatase inhibitors 108
Lipophilicity in Molecular Modeling of MAO Inhibitors. 107
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 107
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 106
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug. 105
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility 105
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 105
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 104
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries 104
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 103
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 103
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 103
TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity 102
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 102
Positional Scanning Libraries of Fluorogenic Substrates for Determining Protease Specificity, Incorporating P1 Diversity. 99
A novel function for non-deterministic scouting of optimal QSAR models out of a highly-structured physicochemical space. 99
Development of purified glycogen derivatives as siRNA nanovectors 97
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 96
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 95
Microfluidic-assisted preparation of targeted ph-responsive polymeric micelles improves gemcitabine effectiveness in pdac: In vitro insights 95
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 94
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 94
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 93
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 93
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 92
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 92
Fast and Reliable Electronic Assay of a Xylella fastidiosa Single Bacterium in Infected Plants Sap 91
An integrated methodology to interface structure- and ligand-based drug design 90
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 90
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities 89
Binding of tracizolines to the imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 87
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 86
Modeling of MAO-A/MAO-B Inhibitory Activity and Selectivity: 2D- and 3D-QSAR Studies. 86
Screening of matrix metalloproteinases available from the protein data bank: Insights into biological functions, domain organization, and zinc binding groups 86
Insights into Diastereospecific Solvolysis of Peptidyl-β-Lactams: Combined Kinetic and Conformational Studies. 85
Structure-Based Design, Solid Phase Synthesis and SAFIR of New Dual Binding Site Acetylcholinesterase (AChE) Inhibitors. 85
Inflammatory Related Reactions in Humans and in Canine Breast Cancers, A Spontaneous Animal Model of Disease 79
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs 77
Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self-Assembled Monolayers 77
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 77
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 75
Sintesi su Fase Solida della Safinamide e di suoi Analoghi. 74
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 74
Molecular Composition and Biological Activity of a Novel Acetonitrile–Water Extract of Lens Culinaris Medik in Murine Native Cells and Cell Lines Exposed to Different Chemotherapeutics Using Mass Spectrometry 74
Fast and highly efficient one-pot synthesis of 9-deazaxanthines 73
New peptidyl-β-lactams: solution-solid phase synthesis for the preparation of antibiotic libraries. 71
Totale 12.873
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Categoria #
all - tutte 52.337
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 52.337
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021339 0 0 0 0 0 0 0 0 0 170 83 86
2021/2022863 59 103 11 20 40 50 54 36 62 107 118 203
2022/20231.439 219 144 95 123 179 170 21 180 236 12 31 29
2023/2024640 34 89 26 110 53 109 24 14 21 45 26 89
2024/20252.253 65 55 190 97 82 154 264 190 112 99 290 655
2025/20264.683 631 381 1.015 475 462 248 508 147 433 383 0 0
Totale 14.190