IRIS
LEONETTI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 5.089
EU - Europa 1.419
AS - Asia 559
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 2
SA - Sud America 2
Totale 7.074
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Nazione #
US - Stati Uniti d'America 5.081
CN - Cina 459
SE - Svezia 414
DE - Germania 272
IT - Italia 266
UA - Ucraina 139
GB - Regno Unito 100
FI - Finlandia 88
RU - Federazione Russa 42
FR - Francia 41
VN - Vietnam 38
IN - India 22
SG - Singapore 22
IE - Irlanda 20
BE - Belgio 16
CZ - Repubblica Ceca 10
CA - Canada 7
IR - Iran 6
EU - Europa 3
HK - Hong Kong 3
JP - Giappone 3
NL - Olanda 3
CH - Svizzera 2
JO - Giordania 2
RS - Serbia 2
AD - Andorra 1
AU - Australia 1
BR - Brasile 1
CO - Colombia 1
ES - Italia 1
IQ - Iraq 1
LT - Lituania 1
MX - Messico 1
MY - Malesia 1
NZ - Nuova Zelanda 1
PK - Pakistan 1
PT - Portogallo 1
TR - Turchia 1
Totale 7.074
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Città #
Fairfield 746
Chandler 547
Woodbridge 445
Ashburn 352
Houston 350
Jacksonville 322
Seattle 313
Nyköping 299
Cambridge 268
Wilmington 239
Ann Arbor 212
Bari 133
Nanjing 105
Roxbury 105
Lawrence 104
Beijing 85
Boardman 59
Des Moines 59
New York 51
Princeton 51
Dearborn 43
Brooklyn 40
Dong Ket 36
Nanchang 32
Hebei 27
Inglewood 27
San Diego 26
Shenyang 25
Jiaxing 23
Boydton 20
Dublin 20
Triggiano 17
Brussels 16
Milan 16
Guangzhou 15
Marseille 15
Los Angeles 14
Paris 14
Tianjin 14
Kansas City 13
Singapore 13
Washington 12
London 11
Pune 11
Changsha 10
Jinan 10
Falls Church 9
Helsinki 9
Shanghai 9
Redwood City 8
San Mateo 8
Norwalk 7
Ardabil 6
Brno 6
Hefei 6
Rome 6
Zhengzhou 6
Auburn Hills 5
Augusta 5
Leawood 5
Munich 5
Prescot 5
Toronto 5
Wuhan 5
Hounslow 4
Kilburn 4
Kunming 4
Mumbai 4
Strasbourg 4
West Jordan 4
Yiwu 4
Grafing 3
Ningbo 3
Noicattaro 3
Taizhou 3
Terlizzi 3
Tokyo 3
Wuxi 3
Amman 2
Belgrade 2
Carmignano 2
Casoria 2
Cava De' Tirreni 2
Chongqing 2
Cosenza 2
Frankfurt am Main 2
Grottaglie 2
Hanoi 2
Hong Kong 2
Jinhua 2
Mola di Bari 2
Monmouth Junction 2
Olomouc 2
Redmond 2
St Albans 2
Xian 2
Acerra 1
Acquaviva delle Fonti 1
Acton 1
Amsterdam 1
Totale 5.569
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 204
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 146
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 136
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 127
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 126
Mind the Gap ! A Journey towards Computational Toxicology 124
Ion channels in drug discovery and safety pharmacology 120
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 112
Molecular docking for predictive toxicology 112
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 111
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 111
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 107
Strategies to improve cancer immune checkpoint inhibitors efficacy, other than abscopal effect: A systematic review 107
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 102
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 102
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 97
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 97
CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer 95
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 94
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 92
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 91
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 89
Strategies of Virtual Screening in Medicinal Chemistry 89
Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on Mitsunobu reaction 87
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility 86
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 85
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 83
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 83
Structure Activity Studies of a Novel Cytotoxic Benzodiazepine 81
null 81
An updated patent review on P-glycoprotein inhibitors (2011-2018) 81
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug. 80
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin 78
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 78
TSPO-targeted NIR-fluorescent ultra-small iron oxide nanoparticles for glioblastoma imaging 77
Design, Synthesis, and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors 76
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 75
Lipophilicity in Molecular Modeling of MAO Inhibitors. 74
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 74
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 73
Attenuation of autoimmune disease in fas-deficient mice by treatment with a cytotoxic benzodiazepine 73
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models. 73
Molecular characterization of a long-term survivor double metastatic non-small cell lung cancer and pancreatic ductal adenocarcinoma treated with gefitinib in combination with gemcitabine plus nab-paclitaxel and mFOLFOX6 as first and second line therapy 73
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 73
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 72
Strategies of multi-objective optimization in drug discovery and development 71
Computational methods for the design of potent aromatase inhibitors 70
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 70
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 69
Positional Scanning Libraries of Fluorogenic Substrates for Determining Protease Specificity, Incorporating P1 Diversity. 67
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 67
Estimation of the Binding Free Energy by Linear Interaction Energy Models 67
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 67
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 66
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities 66
A multitarget approach in cancer research 64
Modeling of MAO-A/MAO-B Inhibitory Activity and Selectivity: 2D- and 3D-QSAR Studies. 63
null 63
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 63
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 61
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 59
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 59
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries 59
A Multi-Objective Optimization Algorithm for Molecular Design 58
A new approach to combine ligand- and structure-based drug design. 57
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 57
Insights into Diastereospecific Solvolysis of Peptidyl-β-Lactams: Combined Kinetic and Conformational Studies. 56
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 56
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 53
Structure-Based Design, Solid Phase Synthesis and SAFIR of New Dual Binding Site Acetylcholinesterase (AChE) Inhibitors. 53
A novel function for non-deterministic scouting of optimal QSAR models out of a highly-structured physicochemical space. 51
Fast and highly efficient one-pot synthesis of 9-deazaxanthines 51
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 50
Sintesi su Fase Solida della Safinamide e di suoi Analoghi. 49
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug 49
Binding of tracizolines to the imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 47
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 47
Screening of matrix metalloproteinases available from the protein data bank: Insights into biological functions, domain organization, and zinc binding groups 46
New peptidyl-beta-lactams: solution-solid phase synthesis for the preparation of antibiotic libraries 44
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 44
2-D and 3-D modeling of imadazoline receptor ligands: insights into pharmacophore 44
An integrated methodology to interface structure- and ligand-based drug design 43
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 43
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 42
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 41
New peptidyl-β-lactams: solution-solid phase synthesis for the preparation of antibiotic libraries. 40
Solid phase synthesis of potential PKs inhibitors 40
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 38
Synthesis and Monoamine Oxidase Inhibitory Activity of new Pyridazine-, Pyrimidine and 1,2,4 Triazine containing Tryciclic derivatives 38
Peptide-aminomethylcoumarin Positional Scanning Libraries for Determining Protease Specificity, Incorporating P1 Diversity 37
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 37
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 37
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) 36
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 35
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 34
Positional Scanning Libraries of Fluorogenic Peptide Substrates for Determining Protease Specificity. 32
Development of purified glycogen derivatives as siRNA nanovectors 30
Microfluidic-assisted preparation of targeted ph-responsive polymeric micelles improves gemcitabine effectiveness in pdac: In vitro insights 30
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 29
Lc-Ms Oxycodone Study: Its Stability in Anapa Devices 27
Totale 7.079
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Categoria #
all - tutte 28.151
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 28.151
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.851 282 102 59 176 191 141 200 176 233 103 146 42
2020/20211.102 111 73 67 150 106 57 52 65 82 170 83 86
2021/2022863 59 103 11 20 40 50 54 36 62 107 118 203
2022/20231.453 221 146 96 124 183 170 21 181 239 12 31 29
2023/2024645 34 91 26 111 54 109 24 14 21 45 26 90
2024/202553 53 0 0 0 0 0 0 0 0 0 0 0
Totale 7.326