IRIS
LEONETTI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 6.917
AS - Asia 2.492
EU - Europa 2.136
SA - Sud America 593
AF - Africa 72
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 3
AN - Antartide 1
Totale 12.217
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Nazione #
US - Stati Uniti d'America 6.850
SG - Singapore 1.045
CN - Cina 715
BR - Brasile 536
SE - Svezia 420
DE - Germania 402
IT - Italia 359
HK - Hong Kong 339
RU - Federazione Russa 306
VN - Vietnam 183
GB - Regno Unito 158
UA - Ucraina 143
FI - Finlandia 123
FR - Francia 74
IN - India 46
CA - Canada 39
ID - Indonesia 37
CI - Costa d'Avorio 29
IE - Irlanda 22
NL - Olanda 22
BE - Belgio 21
IQ - Iraq 20
BD - Bangladesh 19
TR - Turchia 19
AR - Argentina 18
AT - Austria 16
MX - Messico 14
CZ - Repubblica Ceca 13
PL - Polonia 13
ZA - Sudafrica 13
ES - Italia 11
JP - Giappone 11
EC - Ecuador 10
MA - Marocco 8
CO - Colombia 7
IR - Iran 7
JO - Giordania 7
LT - Lituania 7
PY - Paraguay 7
VE - Venezuela 7
DZ - Algeria 5
PK - Pakistan 5
RO - Romania 5
UZ - Uzbekistan 5
AE - Emirati Arabi Uniti 4
AL - Albania 4
GT - Guatemala 4
SA - Arabia Saudita 4
TN - Tunisia 4
AO - Angola 3
CH - Svizzera 3
CL - Cile 3
EG - Egitto 3
EU - Europa 3
IL - Israele 3
JM - Giamaica 3
KG - Kirghizistan 3
KZ - Kazakistan 3
RS - Serbia 3
AU - Australia 2
AZ - Azerbaigian 2
BG - Bulgaria 2
BH - Bahrain 2
BO - Bolivia 2
CR - Costa Rica 2
KE - Kenya 2
KR - Corea 2
NG - Nigeria 2
OM - Oman 2
PS - Palestinian Territory 2
TW - Taiwan 2
UY - Uruguay 2
AD - Andorra 1
AQ - Antartide 1
BA - Bosnia-Erzegovina 1
CD - Congo 1
DO - Repubblica Dominicana 1
EE - Estonia 1
ET - Etiopia 1
GD - Grenada 1
GE - Georgia 1
GI - Gibilterra 1
GP - Guadalupe 1
GR - Grecia 1
HN - Honduras 1
HR - Croazia 1
LK - Sri Lanka 1
LV - Lettonia 1
MK - Macedonia 1
MY - Malesia 1
NP - Nepal 1
NZ - Nuova Zelanda 1
PE - Perù 1
PH - Filippine 1
PR - Porto Rico 1
PT - Portogallo 1
SN - Senegal 1
Totale 12.217
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Città #
Dallas 967
Fairfield 746
Ashburn 566
Chandler 543
Singapore 542
Woodbridge 445
Houston 352
Hong Kong 333
Jacksonville 322
Seattle 318
Nyköping 295
Cambridge 268
Beijing 248
Wilmington 240
Ann Arbor 213
Bari 162
Nanjing 105
Roxbury 105
Lawrence 103
New York 79
Munich 72
Boardman 70
Los Angeles 70
Des Moines 59
Ho Chi Minh City 55
Brooklyn 52
Princeton 51
Dearborn 43
São Paulo 39
Dong Ket 36
Hanoi 35
Helsinki 35
Nanchang 32
Santa Clara 31
Abidjan 29
Buffalo 29
London 29
Hebei 27
Inglewood 27
Jakarta 27
San Diego 26
Shenyang 26
Falkenstein 25
North Bergen 25
Jiaxing 23
Dublin 22
Brussels 21
Boydton 20
Rio de Janeiro 20
Council Bluffs 19
Nuremberg 19
Frankfurt am Main 17
Milan 17
Triggiano 17
Guangzhou 16
Marseille 15
Moscow 15
Toronto 15
Amsterdam 14
Belo Horizonte 14
Paris 14
Tianjin 14
Atlanta 13
Chicago 13
Columbus 13
Kansas City 13
Porto Alegre 12
Pune 12
The Dalles 12
Washington 12
Boston 11
Campinas 11
Florence 11
Rome 11
Tokyo 11
Brasília 10
Changsha 10
Jinan 10
Orem 10
Shanghai 10
Stockholm 10
Warsaw 10
Curitiba 9
Falls Church 9
Johannesburg 9
Poplar 9
Redwood City 8
Salvador 8
San Mateo 8
Turku 8
Amman 7
Augusta 7
Brno 7
Montreal 7
Norwalk 7
Phoenix 7
São José dos Campos 7
Zhengzhou 7
Ankara 6
Ardabil 6
Totale 8.575
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.053
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 221
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 185
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 184
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 183
Mind the Gap ! A Journey towards Computational Toxicology 173
An updated patent review on P-glycoprotein inhibitors (2011-2018) 164
Ion channels in drug discovery and safety pharmacology 162
CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer 159
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 159
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 158
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 153
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 146
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 145
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 144
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 141
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 141
Molecular docking for predictive toxicology 140
Strategies to improve cancer immune checkpoint inhibitors efficacy, other than abscopal effect: A systematic review 138
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 137
Attenuation of autoimmune disease in fas-deficient mice by treatment with a cytotoxic benzodiazepine 134
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 131
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 128
Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on Mitsunobu reaction 127
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 126
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 123
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 121
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 121
A multitarget approach in cancer research 119
Strategies of Virtual Screening in Medicinal Chemistry 119
A Multi-Objective Optimization Algorithm for Molecular Design 118
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 118
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 115
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 115
Design, Synthesis, and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors 111
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models. 110
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 108
Structure Activity Studies of a Novel Cytotoxic Benzodiazepine 107
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 107
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 107
TSPO-targeted NIR-fluorescent ultra-small iron oxide nanoparticles for glioblastoma imaging 107
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 106
Molecular characterization of a long-term survivor double metastatic non-small cell lung cancer and pancreatic ductal adenocarcinoma treated with gefitinib in combination with gemcitabine plus nab-paclitaxel and mFOLFOX6 as first and second line therapy 106
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin 104
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 103
Estimation of the Binding Free Energy by Linear Interaction Energy Models 103
Computational methods for the design of potent aromatase inhibitors 103
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 100
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 100
Lipophilicity in Molecular Modeling of MAO Inhibitors. 99
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug. 98
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility 98
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries 97
2-D and 3-D modeling of imadazoline receptor ligands: insights into pharmacophore 97
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 96
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 95
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 95
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 94
A new approach to combine ligand- and structure-based drug design. 93
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 92
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 91
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 89
Positional Scanning Libraries of Fluorogenic Substrates for Determining Protease Specificity, Incorporating P1 Diversity. 88
Strategies of multi-objective optimization in drug discovery and development 88
TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity 85
A novel function for non-deterministic scouting of optimal QSAR models out of a highly-structured physicochemical space. 85
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 85
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 85
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities 84
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 84
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 83
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 82
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 82
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 80
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 80
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 79
Development of purified glycogen derivatives as siRNA nanovectors 79
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 78
Structure-Based Design, Solid Phase Synthesis and SAFIR of New Dual Binding Site Acetylcholinesterase (AChE) Inhibitors. 78
Modeling of MAO-A/MAO-B Inhibitory Activity and Selectivity: 2D- and 3D-QSAR Studies. 77
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 77
Screening of matrix metalloproteinases available from the protein data bank: Insights into biological functions, domain organization, and zinc binding groups 77
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 75
An integrated methodology to interface structure- and ligand-based drug design 74
Insights into Diastereospecific Solvolysis of Peptidyl-β-Lactams: Combined Kinetic and Conformational Studies. 73
Binding of tracizolines to the imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 71
Sintesi su Fase Solida della Safinamide e di suoi Analoghi. 70
Fast and Reliable Electronic Assay of a Xylella fastidiosa Single Bacterium in Infected Plants Sap 68
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 68
Microfluidic-assisted preparation of targeted ph-responsive polymeric micelles improves gemcitabine effectiveness in pdac: In vitro insights 68
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug 67
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 67
Inflammatory Related Reactions in Humans and in Canine Breast Cancers, A Spontaneous Animal Model of Disease 67
Fast and highly efficient one-pot synthesis of 9-deazaxanthines 66
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 65
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 64
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 64
null 63
Synthesis and Monoamine Oxidase Inhibitory Activity of new Pyridazine-, Pyrimidine and 1,2,4 Triazine containing Tryciclic derivatives 62
Peptide-aminomethylcoumarin Positional Scanning Libraries for Determining Protease Specificity, Incorporating P1 Diversity 60
Totale 11.465
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Categoria #
all - tutte 48.967
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 48.967
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021595 0 0 0 0 0 57 52 65 82 170 83 86
2021/2022863 59 103 11 20 40 50 54 36 62 107 118 203
2022/20231.439 219 144 95 123 179 170 21 180 236 12 31 29
2023/2024640 34 89 26 110 53 109 24 14 21 45 26 89
2024/20252.253 65 55 190 97 82 154 264 190 112 99 290 655
2025/20263.029 631 381 1.015 475 462 65 0 0 0 0 0 0
Totale 12.536