IRIS
LEONETTI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 7.979
AS - Asia 2.992
EU - Europa 2.894
SA - Sud America 759
Continente sconosciuto - Info sul continente non disponibili 332
AF - Africa 116
OC - Oceania 3
AN - Antartide 1
Totale 15.076
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Nazione #
US - Stati Uniti d'America 7.866
SG - Singapore 1.196
IT - Italia 884
CN - Cina 790
BR - Brasile 617
DE - Germania 426
SE - Svezia 422
HK - Hong Kong 356
RU - Federazione Russa 313
VN - Vietnam 237
FR - Francia 182
GB - Regno Unito 178
FI - Finlandia 154
UA - Ucraina 147
IN - India 92
CA - Canada 62
BD - Bangladesh 57
ID - Indonesia 46
AR - Argentina 40
TR - Turchia 31
CI - Costa d'Avorio 29
IQ - Iraq 29
NL - Olanda 28
CO - Colombia 27
IE - Irlanda 24
ZA - Sudafrica 24
MX - Messico 23
BE - Belgio 22
JP - Giappone 22
EC - Ecuador 20
AT - Austria 17
MA - Marocco 17
PK - Pakistan 17
ES - Italia 15
PL - Polonia 15
UZ - Uzbekistan 15
CZ - Repubblica Ceca 14
PY - Paraguay 14
CL - Cile 13
PH - Filippine 13
SA - Arabia Saudita 12
JO - Giordania 11
BO - Bolivia 10
LT - Lituania 10
MY - Malesia 9
TN - Tunisia 9
VE - Venezuela 9
EG - Egitto 8
AZ - Azerbaigian 7
IR - Iran 7
CH - Svizzera 6
DZ - Algeria 6
KE - Kenya 6
RO - Romania 6
AE - Emirati Arabi Uniti 5
AL - Albania 5
ET - Etiopia 5
GT - Guatemala 5
JM - Giamaica 5
KG - Kirghizistan 5
RS - Serbia 5
UY - Uruguay 5
IL - Israele 4
KZ - Kazakistan 4
AO - Angola 3
CR - Costa Rica 3
EU - Europa 3
HU - Ungheria 3
KR - Corea 3
NG - Nigeria 3
NP - Nepal 3
OM - Oman 3
PE - Perù 3
PS - Palestinian Territory 3
SY - Repubblica araba siriana 3
TW - Taiwan 3
AU - Australia 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BH - Bahrain 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
GD - Grenada 2
GE - Georgia 2
HN - Honduras 2
LV - Lettonia 2
PA - Panama 2
PR - Porto Rico 2
PT - Portogallo 2
SN - Senegal 2
TH - Thailandia 2
TT - Trinidad e Tobago 2
AD - Andorra 1
AM - Armenia 1
AQ - Antartide 1
CD - Congo 1
EE - Estonia 1
GI - Gibilterra 1
GN - Guinea 1
GP - Guadalupe 1
Totale 14.734
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Città #
Dallas 975
Fairfield 746
Ashburn 667
Singapore 664
Chandler 544
Woodbridge 445
San Jose 428
Houston 353
Hong Kong 350
Jacksonville 322
Seattle 319
Nyköping 295
Milan 288
Cambridge 268
Beijing 256
Wilmington 241
Ann Arbor 213
Bari 164
Nanjing 105
Roxbury 105
Lauterbourg 104
Lawrence 103
New York 95
Los Angeles 90
Boardman 86
Rome 86
Munich 72
Ho Chi Minh City 70
Helsinki 66
Des Moines 61
Brooklyn 57
Princeton 51
São Paulo 51
Council Bluffs 49
Santa Clara 49
Columbus 44
Hanoi 44
Dearborn 43
Falkenstein 38
Dong Ket 36
London 34
Buffalo 33
Nanchang 32
Abidjan 29
Jakarta 29
San Diego 28
Shenyang 28
Figino 27
Hebei 27
Inglewood 27
Frankfurt am Main 26
North Bergen 25
Dublin 24
Jiaxing 24
Atlanta 22
Brussels 22
Boydton 21
Rio de Janeiro 21
Nuremberg 20
Orem 20
Chicago 19
Tokyo 19
Turin 18
Amsterdam 17
Guangzhou 17
Marseille 17
Toronto 17
Triggiano 17
Moscow 16
Belo Horizonte 15
Kansas City 15
Montreal 15
Paris 15
Boston 14
Tashkent 14
Tianjin 14
Baghdad 13
Campinas 13
Denver 13
Johannesburg 13
Naples 13
Porto Alegre 13
Pune 13
Curitiba 12
Florence 12
The Dalles 12
Washington 12
Amman 11
Brasília 11
Poplar 11
Santiago 11
Shanghai 11
Warsaw 11
Changsha 10
Jinan 10
New Delhi 10
Salvador 10
Stockholm 10
Taranto 10
Chennai 9
Totale 10.095
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.086
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 257
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 213
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 210
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 209
Mind the Gap ! A Journey towards Computational Toxicology 194
CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer 193
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 185
Ion channels in drug discovery and safety pharmacology 184
An updated patent review on P-glycoprotein inhibitors (2011-2018) 183
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 183
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 179
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 172
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 172
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 169
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 166
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 165
Molecular docking for predictive toxicology 165
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 161
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 160
Attenuation of autoimmune disease in fas-deficient mice by treatment with a cytotoxic benzodiazepine 157
Strategies to improve cancer immune checkpoint inhibitors efficacy, other than abscopal effect: A systematic review 153
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 148
A multitarget approach in cancer research 147
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 147
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 144
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 143
Strategies of Virtual Screening in Medicinal Chemistry 139
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 139
A Multi-Objective Optimization Algorithm for Molecular Design 138
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 137
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 137
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 136
Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on Mitsunobu reaction 133
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 133
Molecular characterization of a long-term survivor double metastatic non-small cell lung cancer and pancreatic ductal adenocarcinoma treated with gefitinib in combination with gemcitabine plus nab-paclitaxel and mFOLFOX6 as first and second line therapy 131
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 129
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 127
Structure Activity Studies of a Novel Cytotoxic Benzodiazepine 127
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 127
TSPO-targeted NIR-fluorescent ultra-small iron oxide nanoparticles for glioblastoma imaging 127
Estimation of the Binding Free Energy by Linear Interaction Energy Models 125
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 124
Design, Synthesis, and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors 124
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 123
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin 122
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 122
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models. 121
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 121
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 119
Lipophilicity in Molecular Modeling of MAO Inhibitors. 119
Strategies of multi-objective optimization in drug discovery and development 119
Computational methods for the design of potent aromatase inhibitors 117
2-D and 3-D modeling of imadazoline receptor ligands: insights into pharmacophore 116
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 115
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries 114
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 113
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 113
TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity 112
A new approach to combine ligand- and structure-based drug design. 112
Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility 111
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 111
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 110
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 109
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 109
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 108
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 108
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 107
Positional Scanning Libraries of Fluorogenic Substrates for Determining Protease Specificity, Incorporating P1 Diversity. 107
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug. 107
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 106
A novel function for non-deterministic scouting of optimal QSAR models out of a highly-structured physicochemical space. 103
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 102
Microfluidic-assisted preparation of targeted ph-responsive polymeric micelles improves gemcitabine effectiveness in pdac: In vitro insights 102
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 101
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 99
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 99
Development of purified glycogen derivatives as siRNA nanovectors 99
Fast and Reliable Electronic Assay of a Xylella fastidiosa Single Bacterium in Infected Plants Sap 98
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 98
An integrated methodology to interface structure- and ligand-based drug design 97
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 96
Modeling of MAO-A/MAO-B Inhibitory Activity and Selectivity: 2D- and 3D-QSAR Studies. 95
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 95
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities 95
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 94
Structure-Based Design, Solid Phase Synthesis and SAFIR of New Dual Binding Site Acetylcholinesterase (AChE) Inhibitors. 92
Binding of tracizolines to the imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models 89
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 87
Screening of matrix metalloproteinases available from the protein data bank: Insights into biological functions, domain organization, and zinc binding groups 87
Inflammatory Related Reactions in Humans and in Canine Breast Cancers, A Spontaneous Animal Model of Disease 87
Insights into Diastereospecific Solvolysis of Peptidyl-β-Lactams: Combined Kinetic and Conformational Studies. 86
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 85
Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self-Assembled Monolayers 84
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs 83
Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal 82
Sintesi su Fase Solida della Safinamide e di suoi Analoghi. 80
Peptide-aminomethylcoumarin Positional Scanning Libraries for Determining Protease Specificity, Incorporating P1 Diversity 80
Microwave-assisted solid phase synthesis of Imatinib, a blockbuster anticancer drug 79
New peptidyl-β-lactams: solution-solid phase synthesis for the preparation of antibiotic libraries. 77
Totale 13.600
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Categoria #
all - tutte 56.572
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 56.572
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022863 59 103 11 20 40 50 54 36 62 107 118 203
2022/20231.439 219 144 95 123 179 170 21 180 236 12 31 29
2023/2024640 34 89 26 110 53 109 24 14 21 45 26 89
2024/20252.253 65 55 190 97 82 154 264 190 112 99 290 655
2025/20265.431 631 381 1.015 475 462 248 508 147 433 421 186 524
2026/2027138 138 0 0 0 0 0 0 0 0 0 0 0
Totale 15.076