IRIS
PIEMONTESE, LUCA
 Distribuzione geografica
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Continente #
NA - Nord America 5.765
AS - Asia 2.766
EU - Europa 1.942
SA - Sud America 886
AF - Africa 102
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 3
Totale 11.474
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Nazione #
US - Stati Uniti d'America 5.683
SG - Singapore 1.091
BR - Brasile 766
CN - Cina 701
IT - Italia 422
HK - Hong Kong 389
SE - Svezia 337
RU - Federazione Russa 320
VN - Vietnam 263
DE - Germania 175
GB - Regno Unito 172
FR - Francia 133
UA - Ucraina 99
FI - Finlandia 89
IN - India 85
ID - Indonesia 62
CA - Canada 45
AR - Argentina 38
BD - Bangladesh 35
AT - Austria 33
CI - Costa d'Avorio 28
EC - Ecuador 27
ZA - Sudafrica 24
TR - Turchia 22
IE - Irlanda 21
IQ - Iraq 20
PL - Polonia 20
BE - Belgio 19
ES - Italia 19
PT - Portogallo 19
MX - Messico 18
JP - Giappone 17
CH - Svizzera 13
CO - Colombia 13
NL - Olanda 13
PE - Perù 12
EG - Egitto 11
IR - Iran 10
AU - Australia 9
MA - Marocco 9
PY - Paraguay 9
CL - Cile 8
KR - Corea 8
LT - Lituania 8
VE - Venezuela 8
KE - Kenya 7
JO - Giordania 6
SA - Arabia Saudita 6
AE - Emirati Arabi Uniti 5
DZ - Algeria 5
JM - Giamaica 5
KZ - Kazakistan 5
TW - Taiwan 5
CZ - Repubblica Ceca 4
DO - Repubblica Dominicana 4
EE - Estonia 4
IL - Israele 4
MY - Malesia 4
TN - Tunisia 4
AZ - Azerbaigian 3
BH - Bahrain 3
EU - Europa 3
GR - Grecia 3
SK - Slovacchia (Repubblica Slovacca) 3
TH - Thailandia 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
AL - Albania 2
BG - Bulgaria 2
BO - Bolivia 2
BY - Bielorussia 2
CR - Costa Rica 2
DK - Danimarca 2
GA - Gabon 2
GT - Guatemala 2
HN - Honduras 2
KW - Kuwait 2
LV - Lettonia 2
MD - Moldavia 2
NP - Nepal 2
PH - Filippine 2
PK - Pakistan 2
RS - Serbia 2
SN - Senegal 2
UZ - Uzbekistan 2
AD - Andorra 1
AM - Armenia 1
BF - Burkina Faso 1
BN - Brunei Darussalam 1
CV - Capo Verde 1
ET - Etiopia 1
GE - Georgia 1
GM - Gambi 1
HR - Croazia 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
MG - Madagascar 1
ML - Mali 1
MR - Mauritania 1
NG - Nigeria 1
Totale 11.466
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Città #
Ashburn 647
Fairfield 609
Chandler 476
Singapore 476
Woodbridge 438
Hong Kong 386
Houston 325
Cambridge 287
Nyköping 269
Seattle 246
Jacksonville 208
Ann Arbor 202
Beijing 202
Wilmington 192
Dallas 114
Roxbury 113
Lawrence 112
Ho Chi Minh City 110
Bari 106
New York 97
Nanjing 89
Los Angeles 77
São Paulo 69
Des Moines 68
Princeton 62
Inglewood 56
Boardman 50
Munich 50
Hanoi 48
Jakarta 46
Brooklyn 39
Council Bluffs 38
Santa Clara 37
Jiaxing 33
Moscow 31
Chicago 30
London 30
Abidjan 28
Hebei 28
Marseille 28
Naples 28
Rio de Janeiro 28
North Bergen 27
Buffalo 25
Frankfurt am Main 25
Dong Ket 24
Shanghai 24
Belo Horizonte 23
San Diego 23
Boydton 21
Dublin 21
Fragagnano 21
Guangzhou 21
Atlanta 19
Brussels 19
Helsinki 19
Lisbon 19
San Francisco 19
Chennai 18
Nanchang 18
Milan 17
Tokyo 17
Changsha 16
Johannesburg 16
Warsaw 16
Redwood City 15
Brasília 14
Langenzersdorf 14
Montreal 14
Paris 14
Poplar 14
Redondo Beach 14
Columbus 12
Denver 12
Nuremberg 12
Toronto 12
Augusta 11
Boston 11
Falkenstein 11
Haiphong 11
Shenyang 11
The Dalles 11
Washington 11
Baghdad 10
Campinas 10
Falls Church 10
Manchester 10
Quito 10
Shenzhen 10
Tianjin 10
Wuhan 10
Curitiba 9
Dhaka 9
Guayaquil 9
Rome 9
Salerno 9
Vienna 9
Wuxi 9
Bitonto 8
Cairo 8
Totale 7.459
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 212
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 189
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 189
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 171
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 167
Deep eutectic solvents as novel and effective extraction media for quantitative determination of Ochratoxin A in wheat and derived products 165
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 161
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 144
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 143
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 141
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 140
An innovative approach for the treatment of Alzheimer’s disease: the role of peroxisome proliferator-activated receptors and their ligands in development of alternative therapeutic interventions 140
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 140
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 136
New approaches for prevention and treatment of Alzheimer's disease: a fascinating challenge 136
Heterocyclic compounds as key structures for the interaction with old and new targets in Alzheimer′s disease therapy 135
Reduction of aflatoxins in apricot kernels by electronic and manual color sorting 134
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 134
Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease 133
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 133
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 132
Occurrence of patulin in conventional and organic fruit products in Italy and subsequent exposure assessment 129
Plant Food Supplements with Antioxidant Properties for the Treatment of Chronic and Neurodegenerative Diseases: Benefits or Risks? 128
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 121
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 121
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 120
Hydroxypyridinone derivatives: a fascinating class of chelators with therapeutic applications - an update 118
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 118
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 117
Miscele eutettiche come solventi biocompatibili a basso impatto ambientale per l’estrazione e la determinazione di metaboliti secondari fungini in matrici alimentari 113
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 108
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 108
Design, synthesis, and in vitro evaluation of hydroxybenzimidazole-donepezil analogues as multitarget-directed ligands for the treatment of Alzheimer's disease 107
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 106
The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs 106
Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates 105
Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2‐Hydroxyphenylbenzimidazole-based Scaffolds en Route to Donepezil‐Like Compounds 105
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 105
Aspergillus carbonarius proteases and their possible activity in Ochratoxin A degradation 105
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 105
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 103
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 101
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 99
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 98
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 97
Natural plant food supplements and food coloring agents derived from Vitis Vinifera: a new source of human exposure to ochratoxin A 96
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 96
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 95
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 94
Effect of gaseous ozone treatments on DON, microbial contaminants and technological parameters of wheat and semolina 92
Processo e impianto per il trattamento di mosti e vini 92
Exploring the chelating capacity of 2-hydroxyphenyl-benzimidazole based hybrids with multi-target ability as anti-Alzheimer's agents 89
Exploiting hydroxyphenylbenzimidazol-based hybrids for metal-modulation in potential anti-Alzheimer´s drugs 88
Plant Food Supplements and food coloring agents derived from Vitis vinifera, a new source of human exposure to Ochratoxin A 85
Climate change effect on ochratoxin A production and gene expression in Aspergillus carbonarius 85
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 83
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 82
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 82
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 79
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 78
Ozone treatment as a possible strategy for reductiono of mycotoxins, pesticides and microbial contamination in durum wheat 77
Mixing Traditional and Innovative Approaches for the Prevention and Treatment of Neurodegenerative and Cardiovascular Diseases: An Overview 77
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 77
Effects of temperature and water activity change on ecophysiology of ochratoxigenic Aspergillus carbonarius in field-simulating conditions 75
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease 75
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 74
Synthesis of Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Using Deep Eutectic Solvents 74
Deep Eutectic Solvents as effective media for the extraction of small molecules from natural sources 74
Can foods influence the onset and progress of neurodegenerative diseases? 71
Natural scaffolds with potential metal chelating activity for the multi-target therapy of Alzheimer's Disease: a preliminary study 69
IDENTIFICATION OF A NOVEL PPARRα/γ DUAL AGONIST SHOWING ANTIDIABETIC EFFECTS AND ABLE TO BIND TO CANONICAL AND ALLOSTERIC SITES OF ABLE TO BIND TO CANONICAL AND ALLOSTERIC SITES OF PPARγ 68
Making traditional Italian almond sweets: effects on aflatoxins levels and distribution in final and waste products. 68
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function 68
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease 68
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates 68
Food Industry Byproducts as Starting Material for Innovative, Green Feed Formulation: A Sustainable Alternative for Poultry Feeding 67
SINTESI E VALUTAZIONE BIOLOGICA DI DERIVATI SEMI-RIGIDI DELL'ACIDO 2-(4-CLOROFENOSSI)-3-FENIL-PROPANOICO COME BLOCCANTI DEI CANALI AL CLORO VOLTAGGIO-DIPENDENTI CLC-K 67
Synthesis and biological activity evaluation of novel diphenylmethane-based ligands for PPARα and PPARγ 66
Synthesis of New Copper and Zinc Chelators with Potential Therapeutic Application in the Neurodegenerative Diseases 66
Deep Eutectic Solvents as effective media for the synthesis of Donepezil structure-based hybrids with metal-chelating properties 65
Novel Phenothiazine/Donepezil-Like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease 63
3-((2-(4-Chloro-5-ethoxy-2-nitrophenoxy)acetamido)methyl)phenyl-dimethylcarbamate 63
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 63
Novel small molecules for PPARs modulation and their potential use for treatment of metabolic disorders 63
Green Methods to Recover Bioactive Compounds from Food Industry Waste: A Sustainable Practice from the Perspective of the Circular Economy 62
Repurposing Rivastigmine Anti-AD Drug By Aryloxyacetic Hybridization: Biometal Chelation And Potential Increased Anti-Amyloidogenic Ability 60
Food Coloring Agents and Plant Food Supplements Derived from Vitis vinifera: A New Source of Human Exposure to Ochratoxin A 58
Multiple causes, multiple targets: FAAH as a centerpiece for therapy of multifactorial pathologies. 57
null 56
Discovery of a dual PPARα/γ partial agonist displaying antisteatotic and antidiabetic properties: in silico studies and X-ray structure determination 55
Multi-Target Approach for the Design of New Compounds Potentially Useful for the Prevention and Treatment of Cardiovascular and/or Neurodegenerative Diseases 54
EFFETTI DERIVANTI DALL'INTRODUZIONE DI SOSTITUENTI SUL NUCLEO DIFENILICO DEL COMPOSTO LT175, AGONISTA DUALE DEI RECETTORI NUCLEARI PPARalfa E PPARgamma 52
New rivastigmine-like compounds for the potential treatment of Alzheimer’s disease: a multi-target approach 51
From classical MTDLs to a semi-synthetic innovative green approach: nature-inspired design as a new intriguing opportunity for new anti-Alzheimer’s drugs 51
Metal chelators for the multi-target therapy of Alzheimer's Disease: isolation/synthesis and preliminary biological evaluation of new natural and synthetic compounds. 51
Determinanti Molecolari della Selettività di Recettori Nucleari: Analisi Chemiometrica e Docking di Agonisti Selettivi di Recettori PPARs 49
Rivastigmine-based hybrids: a multi-target approach to anti-Alzheimer’s drug design 46
Occurrence and characterization of penicillium species isolated from post-harvest apples in lebanon 46
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 45
Therapeutic potential of PPARs ligands: towards new fascinating goals 45
Totale 9.638
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Categoria #
all - tutte 51.834
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.834
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021643 0 0 0 0 0 29 95 74 63 196 101 85
2021/2022802 61 59 18 20 34 52 27 41 40 44 130 276
2022/20231.340 214 122 90 97 146 172 15 161 236 18 42 27
2023/2024628 36 82 35 35 59 147 44 38 27 26 29 70
2024/20252.644 180 78 219 123 97 155 278 243 149 174 297 651
2025/20262.897 690 298 436 844 577 52 0 0 0 0 0 0
Totale 12.164