IRIS
STEFANACHI, ANGELA
 Distribuzione geografica
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Continente #
NA - Nord America 8.013
AS - Asia 2.469
EU - Europa 2.431
SA - Sud America 570
Continente sconosciuto - Info sul continente non disponibili 276
AF - Africa 96
OC - Oceania 5
Totale 13.860
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Nazione #
US - Stati Uniti d'America 7.813
SG - Singapore 919
IT - Italia 775
CN - Cina 703
BR - Brasile 462
SE - Svezia 331
DE - Germania 322
RU - Federazione Russa 264
HK - Hong Kong 259
VN - Vietnam 247
GB - Regno Unito 161
FR - Francia 150
FI - Finlandia 130
UA - Ucraina 114
CA - Canada 95
IN - India 67
BD - Bangladesh 55
CI - Costa d'Avorio 40
AR - Argentina 34
ID - Indonesia 34
NL - Olanda 30
TR - Turchia 30
BE - Belgio 28
CO - Colombia 26
IQ - Iraq 26
PK - Pakistan 20
CR - Costa Rica 19
MX - Messico 18
ES - Italia 17
ZA - Sudafrica 17
CZ - Repubblica Ceca 16
IE - Irlanda 16
AT - Austria 14
GT - Guatemala 14
JP - Giappone 14
PH - Filippine 14
PL - Polonia 12
IR - Iran 11
NI - Nicaragua 11
SA - Arabia Saudita 11
EC - Ecuador 10
PY - Paraguay 10
UZ - Uzbekistan 10
CW - ???statistics.table.value.countryCode.CW??? 9
HN - Honduras 9
BO - Bolivia 8
CH - Svizzera 8
JM - Giamaica 8
LT - Lituania 8
MA - Marocco 8
AL - Albania 7
MY - Malesia 7
TN - Tunisia 7
AE - Emirati Arabi Uniti 6
AZ - Azerbaigian 5
DK - Danimarca 5
EG - Egitto 5
SV - El Salvador 5
TT - Trinidad e Tobago 5
VE - Venezuela 5
CL - Cile 4
EU - Europa 4
KE - Kenya 4
KG - Kirghizistan 4
KZ - Kazakistan 4
NP - Nepal 4
PE - Perù 4
PR - Porto Rico 4
PS - Palestinian Territory 4
RO - Romania 4
RS - Serbia 4
SC - Seychelles 4
AU - Australia 3
ET - Etiopia 3
GP - Guadalupe 3
NG - Nigeria 3
OM - Oman 3
SR - Suriname 3
UY - Uruguay 3
AO - Angola 2
DO - Repubblica Dominicana 2
EE - Estonia 2
GR - Grecia 2
HU - Ungheria 2
IL - Israele 2
JO - Giordania 2
LB - Libano 2
NZ - Nuova Zelanda 2
PA - Panama 2
SY - Repubblica araba siriana 2
AD - Andorra 1
BB - Barbados 1
BH - Bahrain 1
BM - Bermuda 1
DZ - Algeria 1
GD - Grenada 1
GE - Georgia 1
GI - Gibilterra 1
GY - Guiana 1
HT - Haiti 1
Totale 13.585
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Città #
Dallas 1.723
Ashburn 699
Singapore 503
Fairfield 476
Chandler 447
San Jose 437
Woodbridge 315
Hong Kong 256
Beijing 255
Jacksonville 246
Milan 234
Nyköping 234
Seattle 231
Houston 222
Wilmington 199
Ann Arbor 183
Cambridge 182
Bari 133
Council Bluffs 126
New York 94
Los Angeles 89
Dong Ket 86
Munich 83
Boardman 81
Nanjing 80
Lauterbourg 76
Roxbury 73
Lawrence 71
Washington 66
Rome 63
Helsinki 58
Santa Clara 49
Brooklyn 48
Ho Chi Minh City 47
São Paulo 44
Princeton 42
Buffalo 41
Abidjan 40
Des Moines 39
Falkenstein 39
Hanoi 39
North Bergen 35
Atlanta 32
Columbus 32
Dearborn 30
Brussels 28
Figino 28
Chicago 26
Inglewood 26
London 25
Frankfurt am Main 24
Kansas City 23
Nanchang 23
Jakarta 22
Orem 22
Toronto 22
Guangzhou 21
Marseille 21
Shenyang 21
Naples 20
Phoenix 20
Jiaxing 19
Montreal 19
Hebei 18
Moscow 18
Turin 18
Amsterdam 17
San Diego 17
Denver 16
Dublin 16
Nuremberg 16
Johannesburg 14
Rio de Janeiro 13
Boston 12
Boydton 12
Florence 12
Paris 12
Shanghai 12
Tokyo 12
Turku 12
Campinas 11
Managua 11
Zhengzhou 11
Bogotá 10
Chennai 10
Guatemala City 10
Poplar 10
Stockholm 10
The Dalles 10
Tianjin 10
Ardabil 9
Baghdad 9
Belo Horizonte 9
Brasília 9
Changsha 9
Dhaka 9
Medellín 9
Tashkent 9
Triggiano 9
Warsaw 9
Totale 9.428
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.103
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 1.087
Synthesis and biological evaluation of N-biphenyl-nicotinic based moiety compounds: A new class of antimitotic agents for the treatment of Hodgkin Lymphoma 263
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 233
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 216
Mind the Gap ! A Journey towards Computational Toxicology 201
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 199
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 196
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor 193
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 190
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 190
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 188
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 185
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 183
A Multi-Objective Optimization Algorithm for Molecular Design 180
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 176
A novel strategy for the treatment of Hodgkin lymphoma 175
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 173
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 171
8-Substituted- 9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B 165
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor 164
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 164
A multitarget approach in cancer research 162
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 161
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 156
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 154
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 154
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 152
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 151
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 151
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 150
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 143
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 142
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 140
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 140
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 138
Synthetic Applications of Polystyrene-Supported 1,1,3,3-Tetramethylguanidine 137
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 137
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 136
Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to 135
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 134
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 134
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 132
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 130
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 129
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 127
Design, synthesis and biological evaluation of 2-aminobenzanilide derivatives as potent and selective HDAC inhibitors 127
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 126
Strategies of multi-objective optimization in drug discovery and development 124
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation 123
Synthesis of 1-Substituted-6-methyluracils 123
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 122
Computational methods for the design of potent aromatase inhibitors 121
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 121
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 121
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 119
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 118
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 116
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 113
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 111
Structural insights into hA2B affinity and selectivity of 9-deazaxanthines from combined ligand- and structure-based approaches 107
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 107
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 106
One-pot assembling pyrroloquinoline quinone glucose dehydrogenase with polydopamine to overcome the reproducibility issues of layer-by-layer electrode development 105
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 104
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 102
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 102
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition 101
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 99
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 98
CC48 a new CB2R agonist/FAAH inhibitor dual drug blocks gastric cancer progression and overcomes paclitaxel resistance 97
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 97
Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self-Assembled Monolayers 95
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs 94
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 94
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 91
Cannabinoid receptor subtype 2 (CB2R): Features and targets for medical applications 88
Conformational Restriction of Designer Drugs Reveals Subtype-Selective and Biased CB2Agonists with Neuroprotective Effects 86
DESIGN SYNTHESIS AND BIOLOGYCAL ACTIVITY OF NEW POTENT GALLOYL-BASED MRP1 INHIBITORS FOR REVERSING MDR 83
Solid phase synthesis of potential PKs inhibitors 83
Structural insights into hA2B affinity and selectivity of 9-deazaxanthines from combined ligand- and structure-based approaches 82
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists 80
Fast and highly efficient one-pot synthesis of 9-deazaxanthines 80
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 79
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 79
Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer’s-Related Targets: A Recent Literature Overview 76
Structural insights into hA2B affinity and selectivity of 9-deazaxanthines (9dAX) from combined ligand- and structure-based approaches 76
Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors. 73
Editorial: Coumarins: New synthetic approaches and new pharmacological applications 66
null 63
Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes 35
Virtual screening-guided repurposing of fluorescent probes to detect EGFR expression in renal cells 20
PROTAC-Based Strategies in Neurodegenerative Diseases: Challenges and Perspectives 7
Totale 13.860
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Categoria #
all - tutte 46.340
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.340
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022503 0 0 0 16 24 37 33 26 41 66 95 165
2022/20231.143 169 113 80 96 155 140 13 146 173 11 21 26
2023/2024483 31 56 23 69 35 87 26 9 20 27 18 82
2024/20251.781 55 51 124 82 60 125 226 148 90 76 250 494
2025/20265.380 511 482 1.579 389 405 210 416 114 387 339 134 414
2026/20271.308 172 158 354 624 0 0 0 0 0 0 0 0
Totale 13.860