IRIS
STEFANACHI, ANGELA
 Distribuzione geografica
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Continente #
NA - Nord America 3.779
EU - Europa 1.194
AS - Asia 697
SA - Sud America 7
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 4
Totale 5.686
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Nazione #
US - Stati Uniti d'America 3.773
CN - Cina 401
SE - Svezia 320
IT - Italia 206
DE - Germania 193
SG - Singapore 154
UA - Ucraina 107
VN - Vietnam 90
GB - Regno Unito 89
FI - Finlandia 86
RU - Federazione Russa 81
FR - Francia 46
BE - Belgio 22
ID - Indonesia 17
IN - India 16
IE - Irlanda 13
CZ - Repubblica Ceca 11
IR - Iran 10
NL - Olanda 7
CA - Canada 5
BR - Brasile 4
CH - Svizzera 4
EU - Europa 4
HK - Hong Kong 4
CO - Colombia 3
NG - Nigeria 3
PK - Pakistan 2
AD - Andorra 1
AO - Angola 1
AT - Austria 1
DZ - Algeria 1
ES - Italia 1
GR - Grecia 1
KG - Kirghizistan 1
LT - Lituania 1
ME - Montenegro 1
MX - Messico 1
PL - Polonia 1
PT - Portogallo 1
SA - Arabia Saudita 1
SK - Slovacchia (Repubblica Slovacca) 1
TR - Turchia 1
Totale 5.686
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Città #
Fairfield 476
Chandler 446
Woodbridge 315
Ashburn 259
Jacksonville 245
Nyköping 234
Seattle 227
Houston 215
Wilmington 196
Ann Arbor 183
Cambridge 182
Singapore 124
Bari 112
Dong Ket 86
Nanjing 80
Roxbury 73
Lawrence 71
Beijing 68
Boardman 57
New York 45
Princeton 42
Des Moines 38
Brooklyn 33
Dearborn 30
Helsinki 27
Inglewood 25
Munich 25
Nanchang 23
Brussels 22
Guangzhou 21
Kansas City 21
Los Angeles 20
Marseille 20
Shenyang 19
Hebei 18
Jiaxing 18
Jakarta 17
Milan 17
San Diego 15
Dublin 13
Santa Clara 13
Washington 13
Boydton 12
Paris 12
Zhengzhou 11
London 10
Tianjin 10
Ardabil 9
Changsha 9
Shanghai 9
Triggiano 9
Ningbo 8
Pune 8
West Jordan 8
Amsterdam 7
Brno 7
Jinan 7
Redwood City 7
Norwalk 6
Strasbourg 6
Toronto 5
Frankfurt am Main 4
Grafing 4
Hanoi 4
Hefei 4
Nuremberg 4
Romola 4
St Albans 4
Taizhou 4
Yiwu 4
Falkenstein 3
Fano 3
Kilburn 3
Kunming 3
Lagos 3
Leawood 3
Prescot 3
Rome 3
San Mateo 3
Secaucus 3
Terlizzi 3
Wuhan 3
Wuxi 3
Acton 2
Auburn Hills 2
Augusta 2
Buffalo 2
Carmignano 2
Casoria 2
Cedar Knolls 2
Düsseldorf 2
Grottaglie 2
Hong Kong 2
Malden 2
Medellín 2
Monmouth Junction 2
North Hollywood 2
Olomouc 2
San Francisco 2
St Petersburg 2
Totale 4.453
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 222
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 221
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 133
Synthesis and biological evaluation of N-biphenyl-nicotinic based moiety compounds: A new class of antimitotic agents for the treatment of Hodgkin Lymphoma 133
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 130
Mind the Gap ! A Journey towards Computational Toxicology 128
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 128
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 125
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 118
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 114
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 114
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor 113
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 111
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 107
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor 101
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 100
A novel strategy for the treatment of Hodgkin lymphoma 96
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 93
Synthetic Applications of Polystyrene-Supported 1,1,3,3-Tetramethylguanidine 92
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 92
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 89
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 88
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 86
Synthesis of 1-Substituted-6-methyluracils 85
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 85
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 84
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 81
8-Substituted- 9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B 81
Design, synthesis and biological evaluation of 2-aminobenzanilide derivatives as potent and selective HDAC inhibitors 80
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 77
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 75
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 74
A multitarget approach in cancer research 73
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 73
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 73
Strategies of multi-objective optimization in drug discovery and development 72
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 72
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 72
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 71
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 70
Computational methods for the design of potent aromatase inhibitors 70
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 69
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 69
A Multi-Objective Optimization Algorithm for Molecular Design 65
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 65
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 64
null 63
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 63
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 63
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 61
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 60
Structural insights into hA2B affinity and selectivity of 9-deazaxanthines from combined ligand- and structure-based approaches 59
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 57
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 55
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 53
Fast and highly efficient one-pot synthesis of 9-deazaxanthines 53
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 52
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 52
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 52
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 47
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 47
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 45
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 45
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 43
Solid phase synthesis of potential PKs inhibitors 42
Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to 42
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 41
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 39
Structural insights into hA2B affinity and selectivity of 9-deazaxanthines from combined ligand- and structure-based approaches 38
DESIGN SYNTHESIS AND BIOLOGYCAL ACTIVITY OF NEW POTENT GALLOYL-BASED MRP1 INHIBITORS FOR REVERSING MDR 36
Structural insights into hA2B affinity and selectivity of 9-deazaxanthines (9dAX) from combined ligand- and structure-based approaches 36
Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors. 33
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 33
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 30
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 20
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 19
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 18
Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self-Assembled Monolayers 16
Editorial: Coumarins: New synthetic approaches and new pharmacological applications 13
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 12
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs 11
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation 9
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists 9
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 8
Cannabinoid receptor subtype 2 (CB2R): Features and targets for medical applications 7
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition 6
Totale 5.922
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Categoria #
all - tutte 24.296
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.296
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020635 0 0 0 0 0 0 138 120 174 81 93 29
2020/2021840 72 50 36 108 91 34 31 51 55 119 57 136
2021/2022651 63 80 5 16 24 37 33 26 41 66 95 165
2022/20231.143 169 113 80 96 155 140 13 146 173 11 21 26
2023/2024483 31 56 23 69 35 87 26 9 20 27 18 82
2024/2025531 55 51 124 82 60 125 34 0 0 0 0 0
Totale 5.922