IRIS
STEFANACHI, ANGELA
 Distribuzione geografica
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Continente #
NA - Nord America 7.050
AS - Asia 2.446
EU - Europa 2.286
SA - Sud America 551
AF - Africa 91
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 4
Totale 12.432
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Nazione #
US - Stati Uniti d'America 6.946
SG - Singapore 917
CN - Cina 699
IT - Italia 666
BR - Brasile 449
SE - Svezia 331
DE - Germania 322
RU - Federazione Russa 258
HK - Hong Kong 257
VN - Vietnam 246
FR - Francia 149
GB - Regno Unito 148
FI - Finlandia 130
UA - Ucraina 114
IN - India 66
CA - Canada 57
BD - Bangladesh 50
CI - Costa d'Avorio 40
AR - Argentina 34
ID - Indonesia 34
TR - Turchia 29
BE - Belgio 27
NL - Olanda 27
IQ - Iraq 26
CO - Colombia 22
PK - Pakistan 19
MX - Messico 18
ZA - Sudafrica 17
CZ - Repubblica Ceca 15
IE - Irlanda 15
AT - Austria 14
ES - Italia 14
JP - Giappone 14
PL - Polonia 12
IR - Iran 11
PH - Filippine 11
PY - Paraguay 10
SA - Arabia Saudita 10
UZ - Uzbekistan 10
EC - Ecuador 9
BO - Bolivia 8
CH - Svizzera 8
MA - Marocco 8
MY - Malesia 7
TN - Tunisia 7
AE - Emirati Arabi Uniti 6
AL - Albania 6
CR - Costa Rica 6
LT - Lituania 6
AZ - Azerbaigian 5
CL - Cile 4
EG - Egitto 4
EU - Europa 4
GT - Guatemala 4
HN - Honduras 4
JM - Giamaica 4
KE - Kenya 4
KG - Kirghizistan 4
NP - Nepal 4
PE - Perù 4
PS - Palestinian Territory 4
RO - Romania 4
VE - Venezuela 4
DK - Danimarca 3
ET - Etiopia 3
KZ - Kazakistan 3
NG - Nigeria 3
OM - Oman 3
RS - Serbia 3
SR - Suriname 3
UY - Uruguay 3
AO - Angola 2
AU - Australia 2
EE - Estonia 2
GR - Grecia 2
HU - Ungheria 2
IL - Israele 2
JO - Giordania 2
LB - Libano 2
NZ - Nuova Zelanda 2
PA - Panama 2
SY - Repubblica araba siriana 2
AD - Andorra 1
BB - Barbados 1
BH - Bahrain 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
GD - Grenada 1
GE - Georgia 1
GI - Gibilterra 1
GP - Guadalupe 1
GY - Guiana 1
HT - Haiti 1
LV - Lettonia 1
ME - Montenegro 1
MK - Macedonia 1
MT - Malta 1
NI - Nicaragua 1
PR - Porto Rico 1
PT - Portogallo 1
Totale 12.426
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Città #
Dallas 1.720
Ashburn 532
Singapore 503
Fairfield 476
Chandler 447
San Jose 347
Woodbridge 315
Hong Kong 254
Beijing 252
Jacksonville 245
Nyköping 234
Seattle 231
Houston 221
Milan 216
Wilmington 198
Ann Arbor 183
Cambridge 182
Bari 129
New York 87
Dong Ket 86
Munich 83
Nanjing 80
Boardman 77
Lauterbourg 76
Los Angeles 75
Roxbury 73
Lawrence 71
Helsinki 58
Rome 58
Ho Chi Minh City 47
Brooklyn 44
Princeton 42
Abidjan 40
Des Moines 39
Falkenstein 39
Hanoi 39
Buffalo 37
São Paulo 35
Council Bluffs 33
Santa Clara 33
Dearborn 30
Brussels 27
North Bergen 27
Inglewood 25
Columbus 24
Figino 24
Frankfurt am Main 24
London 24
Atlanta 23
Kansas City 23
Nanchang 23
Jakarta 22
Orem 22
Chicago 21
Guangzhou 21
Marseille 21
Shenyang 21
Jiaxing 19
Hebei 18
Moscow 18
Amsterdam 16
Montreal 16
Nuremberg 16
San Diego 16
Denver 15
Dublin 15
Toronto 15
Johannesburg 14
Washington 14
Rio de Janeiro 13
Turin 13
Boydton 12
Paris 12
Shanghai 12
Tokyo 12
Turku 12
Boston 11
Campinas 11
Naples 11
Zhengzhou 11
Chennai 10
Poplar 10
Stockholm 10
Tianjin 10
Ardabil 9
Baghdad 9
Belo Horizonte 9
Changsha 9
Dhaka 9
Florence 9
Phoenix 9
Tashkent 9
Triggiano 9
Warsaw 9
Brasília 8
Medellín 8
Ningbo 8
Pune 8
The Dalles 8
West Jordan 8
Totale 8.839
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.085
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 1.069
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 213
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 209
Mind the Gap ! A Journey towards Computational Toxicology 194
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 189
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 185
Synthesis and biological evaluation of N-biphenyl-nicotinic based moiety compounds: A new class of antimitotic agents for the treatment of Hodgkin Lymphoma 183
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 183
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 179
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor 176
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 172
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 171
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 165
A novel strategy for the treatment of Hodgkin lymphoma 164
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 163
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 160
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 160
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor 153
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 151
8-Substituted- 9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B 149
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 148
A multitarget approach in cancer research 146
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 144
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 143
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 139
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 139
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 138
A Multi-Objective Optimization Algorithm for Molecular Design 138
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 137
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 136
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 134
Synthetic Applications of Polystyrene-Supported 1,1,3,3-Tetramethylguanidine 130
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 129
Hydroxy-propil-β-cyclodextrin inclusion complexes of two biphenylnicotinamide derivatives: Formulation and anti-proliferative activity evaluation in pancreatic cancer cell models 129
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 127
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 127
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 123
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 123
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 123
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 122
Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to 122
Enhancing the Sensitivity of Biotinylated Surfaces by Tailoring the Design of the Mixed Self-Assembled Monolayer Synthesis 121
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 119
Strategies of multi-objective optimization in drug discovery and development 119
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 118
Computational methods for the design of potent aromatase inhibitors 117
Design, synthesis and biological evaluation of 2-aminobenzanilide derivatives as potent and selective HDAC inhibitors 116
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 115
Synthesis of 1-Substituted-6-methyluracils 113
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 113
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation 111
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 110
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 109
Negatively charged ions to probe self-assembled monolayer reorganization driven by interchain interactions 109
Surface composition of mixed self-assembled monolayers on Au by infrared attenuated total reflection spectroscopy 108
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 106
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 102
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 102
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 101
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 99
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 99
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 98
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 96
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 95
Structural insights into hA2B affinity and selectivity of 9-deazaxanthines from combined ligand- and structure-based approaches 95
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 93
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 87
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 86
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 85
3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition 84
Controlling the Binding Efficiency of Surface Confined Antibodies through the Design of Mixed Self-Assembled Monolayers 84
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs 82
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 82
One-pot assembling pyrroloquinoline quinone glucose dehydrogenase with polydopamine to overcome the reproducibility issues of layer-by-layer electrode development 79
CC48 a new CB2R agonist/FAAH inhibitor dual drug blocks gastric cancer progression and overcomes paclitaxel resistance 77
Solid phase synthesis of potential PKs inhibitors 77
Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists 75
Structural insights into hA2B affinity and selectivity of 9-deazaxanthines from combined ligand- and structure-based approaches 75
Cannabinoid receptor subtype 2 (CB2R): Features and targets for medical applications 74
DESIGN SYNTHESIS AND BIOLOGYCAL ACTIVITY OF NEW POTENT GALLOYL-BASED MRP1 INHIBITORS FOR REVERSING MDR 73
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 73
Fast and highly efficient one-pot synthesis of 9-deazaxanthines 73
Conformational Restriction of Designer Drugs Reveals Subtype-Selective and Biased CB2Agonists with Neuroprotective Effects 71
Structural insights into hA2B affinity and selectivity of 9-deazaxanthines (9dAX) from combined ligand- and structure-based approaches 71
Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer’s-Related Targets: A Recent Literature Overview 66
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 66
Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors. 65
null 63
Editorial: Coumarins: New synthetic approaches and new pharmacological applications 59
Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes 9
Virtual screening-guided repurposing of fluorescent probes to detect EGFR expression in renal cells 4
Totale 12.694
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Categoria #
all - tutte 42.581
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 42.581
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022651 63 80 5 16 24 37 33 26 41 66 95 165
2022/20231.143 169 113 80 96 155 140 13 146 173 11 21 26
2023/2024483 31 56 23 69 35 87 26 9 20 27 18 82
2024/20251.781 55 51 124 82 60 125 226 148 90 76 250 494
2025/20265.380 511 482 1.579 389 405 210 416 114 387 339 134 414
2026/2027142 142 0 0 0 0 0 0 0 0 0 0 0
Totale 12.694