The reaction of ortho-lithiated aryloxiranes with various enaminones affords straightforwardly new functionalized isochromanes, as a mixture of two epimeric stereoisomers, in reasonable to very good yields (50-90%). The two diastereomers, which show a high structural variability, could be easily separated by column chromatography.
Addition of ortho-Lithiated Aryloxiranes to Enaminones: A Novel Synthesis of Polysubstituted Isochromanes
A. Salomone;PERNA, FILIPPO;CAPRIATI, Vito
2013-01-01
Abstract
The reaction of ortho-lithiated aryloxiranes with various enaminones affords straightforwardly new functionalized isochromanes, as a mixture of two epimeric stereoisomers, in reasonable to very good yields (50-90%). The two diastereomers, which show a high structural variability, could be easily separated by column chromatography.File in questo prodotto:
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