Over the past decades, iron-catalyzed Kumada-type cross-coupling reactions have undergone significant development, particularly for transformations involving alkyl and aryl halides and Grignard reagents. Traditionally, these reactions are carried out in anhydrous THF or Et2O under an inert atmosphere and typically require coordinating additives, such as TMEDA, to achieve optimal catalytic efficiency.¹ Building on our previous studies on Pd-catalyzed cross-couplings of organolithium, Grignard, and organozinc reagents in environmentally benign media such as Deep Eutectic Solvents (DESs),²,³ we investigated the reactivity of these organometallic species under iron catalysis in DESs, with the aim of developing a sustainable protocol for a new C-C bond formation operating under mild and aerobic conditions.
Deep Eutectic Solvents Enable Aerobic Iron-Catalyzed Kumada-Type Cross-Coupling Reactions
luciana cicco;maristella simone;filippo perna;paola vitale;vito capriati
2026-01-01
Abstract
Over the past decades, iron-catalyzed Kumada-type cross-coupling reactions have undergone significant development, particularly for transformations involving alkyl and aryl halides and Grignard reagents. Traditionally, these reactions are carried out in anhydrous THF or Et2O under an inert atmosphere and typically require coordinating additives, such as TMEDA, to achieve optimal catalytic efficiency.¹ Building on our previous studies on Pd-catalyzed cross-couplings of organolithium, Grignard, and organozinc reagents in environmentally benign media such as Deep Eutectic Solvents (DESs),²,³ we investigated the reactivity of these organometallic species under iron catalysis in DESs, with the aim of developing a sustainable protocol for a new C-C bond formation operating under mild and aerobic conditions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
