Zervimesine is a small molecule, able to cross the blood−brain barrier, readily available by straightforward organic chemistry processes, showing few “off-target” effects, but displays a potent and selective S2R modulator profile. Evidence suggests Zervimesine can protect synapses and neurons by preventing the toxic effects of soluble Aβ oligomers.
Zervimesine, a Small Sigma-2 Receptor Selective Modulator for Alzheimer’s Disease
Contino, Marialessandra;Abate, Carmen;
2025-01-01
Abstract
Zervimesine is a small molecule, able to cross the blood−brain barrier, readily available by straightforward organic chemistry processes, showing few “off-target” effects, but displays a potent and selective S2R modulator profile. Evidence suggests Zervimesine can protect synapses and neurons by preventing the toxic effects of soluble Aβ oligomers.File in questo prodotto:
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