Genetic risk for schizophrenia (SZ) is associated with low scores in cognitive performance long before the typical age of onset of SZ. Additionally, common genetic variants may promote resilience to SZ in the presence of genetic risk. If risk and resilience act upon similar brain mechanisms, we expect that higher polygenic risk scores (risk PGS) are associated with poorer cognitive performance, whereas higher polygenic resilience scores (resilience PGS) are associated with better cognitive performance within the same cognitive tasks. We tested this hypothesis in a developmental age and an adult cohort.
COMMON GENETIC VARIATION RELATED TO SCHIZOPHRENIA IS ASSOCIATED WITH COGNITIVE PERFORMANCE
Kikidis, Gianluca C.;Penzel, Nora;Sportelli, Leonardo;Raio, Alessandra;Antonucci, Linda A.;Bertolino, Alessandro;Selvaggi, Pierluigi;Rampino, Antonio;Pergola, Giulio
2022-01-01
Abstract
Genetic risk for schizophrenia (SZ) is associated with low scores in cognitive performance long before the typical age of onset of SZ. Additionally, common genetic variants may promote resilience to SZ in the presence of genetic risk. If risk and resilience act upon similar brain mechanisms, we expect that higher polygenic risk scores (risk PGS) are associated with poorer cognitive performance, whereas higher polygenic resilience scores (resilience PGS) are associated with better cognitive performance within the same cognitive tasks. We tested this hypothesis in a developmental age and an adult cohort.File in questo prodotto:
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