Accumulating evidence converges on a characteristic pattern of lower fronto-temporal cortical thickness in patients with schizophrenia (SZ) compared to controls. However, SZ is a heterogeneous disorder, and conventional mean-based analyses may disguise a substantial heterogeneity among patients. A recent meta-analysis reported higher brain volume variability in SZ patients in several cortical and subcortical structures lower variability in anterior cingulate volume as compared to healthy taken to indicate a pervasive involvement of the anterior cingulate in SZ. Here, we compared regional brain structural dispersion within patients with SZ and controls using a mega-analytic approach.
Brain Variability in Schizophrenia Spectrum Disorder
Giulio Pergola;Tiziana Quarto;Alessandro Bertolino;
2018-01-01
Abstract
Accumulating evidence converges on a characteristic pattern of lower fronto-temporal cortical thickness in patients with schizophrenia (SZ) compared to controls. However, SZ is a heterogeneous disorder, and conventional mean-based analyses may disguise a substantial heterogeneity among patients. A recent meta-analysis reported higher brain volume variability in SZ patients in several cortical and subcortical structures lower variability in anterior cingulate volume as compared to healthy taken to indicate a pervasive involvement of the anterior cingulate in SZ. Here, we compared regional brain structural dispersion within patients with SZ and controls using a mega-analytic approach.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
