The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are known to be differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often found to be impaired in individuals with brain disorders associated with reduced hippocampal volume, including Alzheimer's disease (AD) and schizophrenia. Given these structural and functional differences, we sought to characterize the subfields’ shared and specific genetic architecture.
Genetic Architecture of Hippocampal Subfield Volumes: Shared and Specific Influences
Alessandro Bertolino;Giulio Pergola;
2018-01-01
Abstract
The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are known to be differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often found to be impaired in individuals with brain disorders associated with reduced hippocampal volume, including Alzheimer's disease (AD) and schizophrenia. Given these structural and functional differences, we sought to characterize the subfields’ shared and specific genetic architecture.File in questo prodotto:
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