Patients with schizophrenia (scz) display a pattern of grey matter abnormalities in the prefrontal cortex (PFC), the thalamus and the cerebellum, as shown by voxel-based morphometry studies. Furthermore, post-mortem studies indicate in patients neuronal loss in specific sub- regions of the thalamus such as the mediodorsal thalamic nucleus (MD). However, it is unclear to what extent these alterations in schizophrenia are associated with the genetic risk or with state-specific factors. The present study investigated the association between genetic risk for schizophrenia and grey matter volume abnormalities.
Grey matter volume alterations in patients with schizophrenia and unaffected siblings show region-specific effects of genetic risk and disease-related factors
Silvestro Trizio;Giulio Pergola;Annabella Di Giorgio;Enrico D’Ambrosio;Ileana Andriola;Barbara Gelao;Paolo Taurisano;Leonardo Fazio;Giuseppe Blasi;Alessandro Bertolino
2014-01-01
Abstract
Patients with schizophrenia (scz) display a pattern of grey matter abnormalities in the prefrontal cortex (PFC), the thalamus and the cerebellum, as shown by voxel-based morphometry studies. Furthermore, post-mortem studies indicate in patients neuronal loss in specific sub- regions of the thalamus such as the mediodorsal thalamic nucleus (MD). However, it is unclear to what extent these alterations in schizophrenia are associated with the genetic risk or with state-specific factors. The present study investigated the association between genetic risk for schizophrenia and grey matter volume abnormalities.File in questo prodotto:
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