Straightforward Tactics and Enabling Technologies as Useful Tools for Fluoroalkylations

Organofluorine compounds are interesting molecules with broad applications in medicinal chemistry, material chemistry and agrochemistry. The development of new synthetic strategies to access new molecules with fluorinated moieties still remains a challenge for organic chemists and a “hot topic” in modern synthesis. The importance of organofluorine chemistry is showcased by the presence of fluorine in nearly 20% of all pharmaceuticals and 35% of agrochemicals on the market. It is therefore noteworthy to develop effective synthetic strategies, either for the incorporation of fluorine atoms into organic scaffolds or for the preparation of fluorinated building blocks. In this communication, we report our contribute in the development of strategies for direct fluoroalkylation. The potential of flow microreactor technology in fluoroalkylation chemistry will be also reported.