Sustainable Routes for the Preparation of Nitrogen-containing Heterocyclic Compounds in Deep Eutectic Solvents

Nowadays, the environmental, health, and safety constraints imposed by current society are forcing chemists to reshape long-established paradigms, while concepts such as biorenewable resources, sustainability and circular economy are being rapidly implemented in the chemical industry.1 Over the last few years, our research group was focused on the sustainable advancement to the synthesis of heterocyclic compounds such as tetrahydrofuran,2 thiophene,3 and triazole derivatives4 in the so-called Deep Eutectic Solvents (DESs) and water. In this communication, we report on the synthesis of N-containing heterocyclic compounds such as 2,5-diarylpyrazines 1,5 2- aroylimidazoles 2, and 2,4-diaroyl-6-arylpyrimidines 3,6 which are important scaffolds in several biologically active and pharmaceutically relevant molecules, from phenacyl azides, under mild conditions, and using DESs as environmentally responsible media both as solvents and catalysts.