MANGIATORDI, Giuseppe Felice
MANGIATORDI, Giuseppe Felice
17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer
2021-01-01 Gargano, E. M.; Mohamed, A.; Abdelsamie, A. S.; Mangiatordi, G. F.; Drzewiecka, H.; Jagodzinski, P. P.; Mazzini, A.; Van Koppen, C. J.; Laschke, M. W.; Nicolotti, O.; Carotti, A.; Marchais-Oberwinkler, S.; Hartmann, R. W.; Frotscher, M.
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach
2023-01-01 Abatematteo, Francesca Serena; Delre, Pietro; Mercurio, Ivan; Rezelj, Veronica V; Siliqi, Dritan; Beaucourt, Stephanie; Lattanzi, Gianluca; Colabufo, Nicola Antonio; Leopoldo, Marcello; Saviano, Michele; Vignuzzi, Marco; Mangiatordi, Giuseppe Felice; Abate, Carmen
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL)
2019-01-01 Alberga, Domenico; Trisciuzzi, Daniela; Montaruli, Michele; Leonetti, Francesco; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions
2017-01-01 Imbrici, Paola; Altamura, Concetta; Gualandi, Francesca; Mangiatordi, Giuseppe Felice; Neri, Marcella; De Maria, Giovanni; Ferlini, Alessandra; Padovani, Alessandro; D'Adamo, Maria Cristina; Nicolotti, Orazio; Pessia, Mauro; Conte, Diana; Filosto, Massimiliano; Desaphy, Jean-Francois
A Round Trip from Medicinal Chemistry to Predictive Toxicology
2016-01-01 Mangiatordi, Giuseppe Felice; Carotti, Angelo; Novellino, Ettore; Nicolotti, Orazio
Accelerating drug discovery by early protein drug target prediction based on a multi-fingerprint similarity search †
2019-01-01 Montaruli, M.; Alberga, D.; Ciriaco, F.; Trisciuzzi, D.; Tondo, A. R.; Mangiatordi, G. F.; Nicolotti, O.
ALPACA: A machine Learning Platform for Affinity and selectivity profiling of CAnnabinoids receptors modulators
2023-01-01 Delre, Pietro; Contino, Marialessandra; Alberga, Domenico; Saviano, Michele; Corriero, Nicola; Mangiatordi, Giuseppe Felice
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis
2024-01-01 Lomuscio, Maria Cristina; Abate, Carmen; Alberga, Domenico; Laghezza, Antonio; Corriero, Nicola; Colabufo, Nicola Antonio; Saviano, Michele; Delre, Pietro; Mangiatordi, Giuseppe Felice
Applicability Domain for QSAR models: where theory meets reality
2016-01-01 Gadaleta, Domenico; Mangiatordi, Giuseppe Felice; Catto, Marco; Carotti, Angelo; Nicolotti, Orazio
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors
2018-01-01 Mangiatordi, G. F.; Trisciuzzi, D.; Iacobazzi, R.; Denora, N.; Pisani, L.; Catto, M.; Leonetti, F.; Alberga, D.; Nicolotti, O.
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration
2020-01-01 Mangiatordi, Giuseppe Felice; Intranuovo, Francesca; Delre, Pietro; Abatematteo, Francesca Serena; Abate, Carmen; Niso, Mauro; Creanza, Teresa Maria; Ancona, Nicola; Stefanachi, Angela; Contino, Marialessandra
CATMoS: Collaborative Acute Toxicity Modeling Suite
2021-01-01 Mansouri, K; Karmaus, Al; Fitzpatrick, J; Patlewicz, G; Pradeep, P; Alberga, D; Alepee, N; Allen, Teh; Allen, D; Alves, Vm; Andrade, Ch; Auernhammer, Tr; Ballabio, D; Bell, S; Benfenati, E; Bhattacharya, S; Bastos, Jv; Boyd, S; Brown, Jb; Capuzzi, Sj; Chushak, Y; Ciallella, H; Clark, Am; Consonni, V; Daga, Pr; Ekins, S; Farag, S; Fedorov, M; Fourches, D; Gadaleta, D; Gao, F; Gearhart, Jm; Goh, G; Goodman, Jm; Grisoni, F; Grulke, Cm; Hartung, T; Hirn, M; Karpov, P; Korotcov, A; Lavado, Gj; Lawless, M; Li, Xh; Luechtefeld, T; Lunghini, F; Mangiatordi, Gf; Marcou, G; Marsh, D; Martin, T; Mauri, A; Muratov, En; Myatt, Gj; Nguyen, Dt; Nicolotti, O; Note, R; Pande, P; Parks, Ak; Peryea, T; Polash, Ah; Rallo, R; Roncaglioni, A; Rowlands, C; Ruiz, P; Russo, Dp; Sayed, A; Sayre, R; Sheils, T; Siegel, C; Silva, Ac; Simeonov, A; Sosnin, S; Southall, N; Strickland, J; Tang, Y; Teppen, B; Tetko, Iv; Thomas, D; Tkachenko, V; Todeschini, R; Toma, C; Tripodi, I; Trisciuzzi, D; Tropsha, A; Varnek, A; Vukovic, K; Wang, Zy; Wang, Lg; Waters, Km; Wedlake, Aj; Wijeyesakere, Sj; Wilson, D; Xiao, Zj; Yang, Hb; Zahoranszky-Kohalmi, G; Zakharov, Av; Zhang, Ff; Zhang, Z; Zhao, Tg; Zhu, H; Zorn, Km; Casey, W; Kleinstreuer, Nc
CERAPP: Collaborative estrogen receptor activity prediction project
2016-01-01 Mansouri, Kamel; Abdelaziz, Ahmed; Rybacka, Aleksandra; Roncaglioni, Alessandra; Tropsha, Alexander; Varnek, Alexandre; Zakharov, Alexey; Worth, Andrew; Richard, Ann M.; Grulke, Christopher M.; Trisciuzzi, Daniela; Fourches, Denis; Horvath, Dragos; Benfenati, Emilio; Muratov, Eugene; Wedebye, Eva Bay; Grisoni, Francesca; Mangiatordi, Giuseppe Felice; Incisivo, Giuseppina M.; Hong, Huixiao; Ng, Hui W.; Tetko, Igor V.; Balabin, Ilya; Kancherla, Jayaram; Shen, Jie; Burton, Julien; Nicklaus, Marc; Cassotti, Matteo; Nikolov, Nikolai G.; Nicolotti, Orazio; Andersson, Patrik L.; Zang, Qingda; Politi, Regina; Beger, Richard D.; Todeschini, Roberto; Huang, Ruili; Farag, Sherif; Rosenberg, Sine A.; Slavov, Svetoslav; Hu, Xin; Judson, Richard S.
Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields
2015-01-01 Mangiatordi, Giuseppe Felice; Alberga, Domenico; Siragusa, Lydia; Goracci, Laura; Lattanzi, Gianluca; Nicolotti, Orazio
Comparative Molecular Dynamics Study of Neuromyelitis Optica-Immunoglobulin G Binding to Aquaporin-4 Extracellular Domains
2017-01-01 Alberga, Domenico; Trisciuzzi, Daniela; Lattanzi, Gianluca; Bennett, Jeffrey; Verkman, Alan; Mangiatordi, Giuseppe; Nicolotti, Orazio
DeLA-Drug: A Deep Learning Algorithm for Automated Design of Druglike Analogues
2022-01-01 Creanza, Teresa Maria; Lamanna, Giuseppe; Delre, Pietro; Contino, Marialessandra; Corriero, Nicola; Saviano, Michele; Mangiatordi, Giuseppe Felice; Ancona, Nicola
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation
2024-01-01 Alberga, D.; Lamanna, G.; Graziano, G.; Delre, P.; Lomuscio, M. C.; Corriero, N.; Ligresti, A.; Siliqi, D.; Saviano, M.; Contino, M.; Stefanachi, A.; Mangiatordi, G. F.
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R)
2020-01-01 Spinelli, F.; Giampietro, R.; Stefanachi, A.; Riganti, C.; Kopecka, J.; Abatematteo, F. S.; Leonetti, F.; Colabufo, N. A.; Mangiatordi, G. F.; Nicolotti, O.; Perrone, M. G.; Brea, J.; Loza, M. I.; Infantino, V.; Abate, C.; Contino, M.
Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors
2018-01-01 Mangiatordi, Giuseppe Felice; Guzzo, Tatiana; Rossano, Eugenio Claudio; Trisciuzzi, Daniela; Alberga, Domenico; Fasciglione, Giovanni; Coletta, Massimiliano; Topai, Alessandra; Nicolotti, Orazio
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness
2016-01-01 Stefanachi, Angela; Mangiatordi, Giuseppe Felice; Tardia, Piero; Alberga, Domenico; Leonetti, Francesco; Niso, Mauro; Colabufo, Nicola Antonio; Adamo, Carlo; Nicolotti, Orazio; Cellamare, Saverio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer | 1-gen-2021 | Gargano, E. M.; Mohamed, A.; Abdelsamie, A. S.; Mangiatordi, G. F.; Drzewiecka, H.; Jagodzinski, P. P.; Mazzini, A.; Van Koppen, C. J.; Laschke, M. W.; Nicolotti, O.; Carotti, A.; Marchais-Oberwinkler, S.; Hartmann, R. W.; Frotscher, M. | |
| A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach | 1-gen-2023 | Abatematteo, Francesca Serena; Delre, Pietro; Mercurio, Ivan; Rezelj, Veronica V; Siliqi, Dritan; Beaucourt, Stephanie; Lattanzi, Gianluca; Colabufo, Nicola Antonio; Leopoldo, Marcello; Saviano, Michele; Vignuzzi, Marco; Mangiatordi, Giuseppe Felice; Abate, Carmen | |
| A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) | 1-gen-2019 | Alberga, Domenico; Trisciuzzi, Daniela; Montaruli, Michele; Leonetti, Francesco; Mangiatordi, Giuseppe Felice; Nicolotti, Orazio | |
| A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions | 1-gen-2017 | Imbrici, Paola; Altamura, Concetta; Gualandi, Francesca; Mangiatordi, Giuseppe Felice; Neri, Marcella; De Maria, Giovanni; Ferlini, Alessandra; Padovani, Alessandro; D'Adamo, Maria Cristina; Nicolotti, Orazio; Pessia, Mauro; Conte, Diana; Filosto, Massimiliano; Desaphy, Jean-Francois | |
| A Round Trip from Medicinal Chemistry to Predictive Toxicology | 1-gen-2016 | Mangiatordi, Giuseppe Felice; Carotti, Angelo; Novellino, Ettore; Nicolotti, Orazio | |
| Accelerating drug discovery by early protein drug target prediction based on a multi-fingerprint similarity search † | 1-gen-2019 | Montaruli, M.; Alberga, D.; Ciriaco, F.; Trisciuzzi, D.; Tondo, A. R.; Mangiatordi, G. F.; Nicolotti, O. | |
| ALPACA: A machine Learning Platform for Affinity and selectivity profiling of CAnnabinoids receptors modulators | 1-gen-2023 | Delre, Pietro; Contino, Marialessandra; Alberga, Domenico; Saviano, Michele; Corriero, Nicola; Mangiatordi, Giuseppe Felice | |
| AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis | 1-gen-2024 | Lomuscio, Maria Cristina; Abate, Carmen; Alberga, Domenico; Laghezza, Antonio; Corriero, Nicola; Colabufo, Nicola Antonio; Saviano, Michele; Delre, Pietro; Mangiatordi, Giuseppe Felice | |
| Applicability Domain for QSAR models: where theory meets reality | 1-gen-2016 | Gadaleta, Domenico; Mangiatordi, Giuseppe Felice; Catto, Marco; Carotti, Angelo; Nicolotti, Orazio | |
| Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors | 1-gen-2018 | Mangiatordi, G. F.; Trisciuzzi, D.; Iacobazzi, R.; Denora, N.; Pisani, L.; Catto, M.; Leonetti, F.; Alberga, D.; Nicolotti, O. | |
| Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration | 1-gen-2020 | Mangiatordi, Giuseppe Felice; Intranuovo, Francesca; Delre, Pietro; Abatematteo, Francesca Serena; Abate, Carmen; Niso, Mauro; Creanza, Teresa Maria; Ancona, Nicola; Stefanachi, Angela; Contino, Marialessandra | |
| CATMoS: Collaborative Acute Toxicity Modeling Suite | 1-gen-2021 | Mansouri, K; Karmaus, Al; Fitzpatrick, J; Patlewicz, G; Pradeep, P; Alberga, D; Alepee, N; Allen, Teh; Allen, D; Alves, Vm; Andrade, Ch; Auernhammer, Tr; Ballabio, D; Bell, S; Benfenati, E; Bhattacharya, S; Bastos, Jv; Boyd, S; Brown, Jb; Capuzzi, Sj; Chushak, Y; Ciallella, H; Clark, Am; Consonni, V; Daga, Pr; Ekins, S; Farag, S; Fedorov, M; Fourches, D; Gadaleta, D; Gao, F; Gearhart, Jm; Goh, G; Goodman, Jm; Grisoni, F; Grulke, Cm; Hartung, T; Hirn, M; Karpov, P; Korotcov, A; Lavado, Gj; Lawless, M; Li, Xh; Luechtefeld, T; Lunghini, F; Mangiatordi, Gf; Marcou, G; Marsh, D; Martin, T; Mauri, A; Muratov, En; Myatt, Gj; Nguyen, Dt; Nicolotti, O; Note, R; Pande, P; Parks, Ak; Peryea, T; Polash, Ah; Rallo, R; Roncaglioni, A; Rowlands, C; Ruiz, P; Russo, Dp; Sayed, A; Sayre, R; Sheils, T; Siegel, C; Silva, Ac; Simeonov, A; Sosnin, S; Southall, N; Strickland, J; Tang, Y; Teppen, B; Tetko, Iv; Thomas, D; Tkachenko, V; Todeschini, R; Toma, C; Tripodi, I; Trisciuzzi, D; Tropsha, A; Varnek, A; Vukovic, K; Wang, Zy; Wang, Lg; Waters, Km; Wedlake, Aj; Wijeyesakere, Sj; Wilson, D; Xiao, Zj; Yang, Hb; Zahoranszky-Kohalmi, G; Zakharov, Av; Zhang, Ff; Zhang, Z; Zhao, Tg; Zhu, H; Zorn, Km; Casey, W; Kleinstreuer, Nc | |
| CERAPP: Collaborative estrogen receptor activity prediction project | 1-gen-2016 | Mansouri, Kamel; Abdelaziz, Ahmed; Rybacka, Aleksandra; Roncaglioni, Alessandra; Tropsha, Alexander; Varnek, Alexandre; Zakharov, Alexey; Worth, Andrew; Richard, Ann M.; Grulke, Christopher M.; Trisciuzzi, Daniela; Fourches, Denis; Horvath, Dragos; Benfenati, Emilio; Muratov, Eugene; Wedebye, Eva Bay; Grisoni, Francesca; Mangiatordi, Giuseppe Felice; Incisivo, Giuseppina M.; Hong, Huixiao; Ng, Hui W.; Tetko, Igor V.; Balabin, Ilya; Kancherla, Jayaram; Shen, Jie; Burton, Julien; Nicklaus, Marc; Cassotti, Matteo; Nikolov, Nikolai G.; Nicolotti, Orazio; Andersson, Patrik L.; Zang, Qingda; Politi, Regina; Beger, Richard D.; Todeschini, Roberto; Huang, Ruili; Farag, Sherif; Rosenberg, Sine A.; Slavov, Svetoslav; Hu, Xin; Judson, Richard S. | |
| Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields | 1-gen-2015 | Mangiatordi, Giuseppe Felice; Alberga, Domenico; Siragusa, Lydia; Goracci, Laura; Lattanzi, Gianluca; Nicolotti, Orazio | |
| Comparative Molecular Dynamics Study of Neuromyelitis Optica-Immunoglobulin G Binding to Aquaporin-4 Extracellular Domains | 1-gen-2017 | Alberga, Domenico; Trisciuzzi, Daniela; Lattanzi, Gianluca; Bennett, Jeffrey; Verkman, Alan; Mangiatordi, Giuseppe; Nicolotti, Orazio | |
| DeLA-Drug: A Deep Learning Algorithm for Automated Design of Druglike Analogues | 1-gen-2022 | Creanza, Teresa Maria; Lamanna, Giuseppe; Delre, Pietro; Contino, Marialessandra; Corriero, Nicola; Saviano, Michele; Mangiatordi, Giuseppe Felice; Ancona, Nicola | |
| DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation | 1-gen-2024 | Alberga, D.; Lamanna, G.; Graziano, G.; Delre, P.; Lomuscio, M. C.; Corriero, N.; Ligresti, A.; Siliqi, D.; Saviano, M.; Contino, M.; Stefanachi, A.; Mangiatordi, G. F. | |
| Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) | 1-gen-2020 | Spinelli, F.; Giampietro, R.; Stefanachi, A.; Riganti, C.; Kopecka, J.; Abatematteo, F. S.; Leonetti, F.; Colabufo, N. A.; Mangiatordi, G. F.; Nicolotti, O.; Perrone, M. G.; Brea, J.; Loza, M. I.; Infantino, V.; Abate, C.; Contino, M. | |
| Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors | 1-gen-2018 | Mangiatordi, Giuseppe Felice; Guzzo, Tatiana; Rossano, Eugenio Claudio; Trisciuzzi, Daniela; Alberga, Domenico; Fasciglione, Giovanni; Coletta, Massimiliano; Topai, Alessandra; Nicolotti, Orazio | |
| Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness | 1-gen-2016 | Stefanachi, Angela; Mangiatordi, Giuseppe Felice; Tardia, Piero; Alberga, Domenico; Leonetti, Francesco; Niso, Mauro; Colabufo, Nicola Antonio; Adamo, Carlo; Nicolotti, Orazio; Cellamare, Saverio |