Canine parvovirus (CPV) modified live virus vaccines are able to infect vaccinated dogs replicating in the bloodstream and enteric mucosa. However, the exact duration and extent of CPV vaccine-induced viremia and fecal shedding arenot known. With the aim to fill this gap, 26 dogs were administeredtwo commercial vaccines containing a CPV-2 orCPV-2b strain and monitored for 28 days after vaccination. By using real-timePCR, vaccine-induced viremia and shedding were found to be long lasting for both vaccinal strains (19-22 and 12-19 mean days, respectively), occurring at higher loads for the CPV-2b strain. With neither vaccine there was any interference with in-clinic or hemagglutination testing. The present study adds new insights into the CPV vaccine persistence in the organism and possible interference with diagnostic tests.
Long-term shedding and viremia after canine parvovirus vaccination
DECARO, Nicola;CRESCENZO, Giuseppe;CAVALLI, Alessandra;LUCENTE, MARIA STELLA;
2014-01-01
Abstract
Canine parvovirus (CPV) modified live virus vaccines are able to infect vaccinated dogs replicating in the bloodstream and enteric mucosa. However, the exact duration and extent of CPV vaccine-induced viremia and fecal shedding arenot known. With the aim to fill this gap, 26 dogs were administeredtwo commercial vaccines containing a CPV-2 orCPV-2b strain and monitored for 28 days after vaccination. By using real-timePCR, vaccine-induced viremia and shedding were found to be long lasting for both vaccinal strains (19-22 and 12-19 mean days, respectively), occurring at higher loads for the CPV-2b strain. With neither vaccine there was any interference with in-clinic or hemagglutination testing. The present study adds new insights into the CPV vaccine persistence in the organism and possible interference with diagnostic tests.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
