The role of hyaluronic acid in the treatment of periodontal disease: a systematic review

Periodontal disease (PD) is a chronic inflammatory condition affecting the tooth-supporting structures, significantly impacting oral health and potentially leading to tooth loss if untreated. This review examines the role of Hyaluronic acid (HA) in the treatment of PD, emphasizing its ability to reduce inflammation, promote gum healing, and support tissue regeneration, particularly in periodontitis and gingivitis. Thirteen articles were included for qualitative analysis after screening titles, abstracts and full texts, with quality assessed using the ROBINS method. HA has demonstrated promising results as an adjunct in periodontal therapy, improving clinical outcomes such as Periodontal probing depth (PPD) and Clinical attachment level (CAL). However, limitations such as short follow-up durations, lack of patient-reported outcomes, and the need for more diverse research populations were noted. HA has emerged as a promising adjunct in periodontal therapy. Its regenerative and anti-inflammatory properties are especially beneficial for patients with advanced PD. Despite positive results, further research is needed to optimize concentration, delivery methods, and long-term effectiveness.