Simple Summary In this observational study, we aimed to describe the cardiorespiratory variations during laparoscopic abdominal surgery in baboons (Papio hamadryas) anesthetized via a laryngeal mask. Animals were immobilized with a combination of tiletamine/zolazepam and medetomidine. A laryngeal mask was inserted to allow for the delivery of oxygen and isoflurane. Cardiovascular variables showed no alterations, while the respiratory parameters indicated a rise in respiratory rate and end-tidal carbon dioxide concentration during the pneumoperitoneum. Hypercapnia was mild, even with the animal in spontaneous breathing, and it was solved rapidly after the discontinuation of the pneumoperitoneum. The results of this study suggest that laparoscopy can be performed safely in spontaneously breathing baboons. Furthermore, adequate ventilation and gas exchange can be achieved using a laryngeal mask without the need for endotracheal intubation. The study aims to describe the anesthetic and airway management of baboons (Papio hamadryas) undergoing laparoscopic salpingectomy with a laryngeal mask airway (LMA) device. Eleven baboons received tiletamine-zolazepam and medetomidine; anesthesia was induced with propofol. An LMA was positioned for oxygen and isoflurane administration in spontaneous respiration. Heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR), end tidal carbon dioxide (EtCO2), minute volume (MV), and peripheral hemoglobin oxygen saturation (SpO(2)) were recorded before (PREPP) and immediately after abdomen insufflation (PP1), at 10 (PP2), 20 (PP3), and 30 (PP4) minutes during pneumoperitoneum, and after (POSTPP) pneumoperitoneum. The respiratory rate was significantly higher at all times compared to PREPP. The end tidal carbon dioxide concentration was significantly higher at PP2, PP3, PP4, and POSTPP, compared to the previous times. The higher values for RR and EtCO2 were registered at PP4: 22.7 (95% CI 17.6-27.8) breaths/min and 57.9 (95% CI 51.9-63.8) mmHg, respectively. The minute volume was significantly higher at PP4 and POSTPP compared to the other times. The higher value for MV was registered at POSTPP (269.1 (95% CI 206.1-331.8) mL/kg/min). This protocol is suitable for baboons undergoing laparoscopic salpingectomy. The LMA was easy to insert and allowed for good ventilation, gas exchange, and delivery of the anesthetic in spontaneous breathing baboons.
Use of Laryngeal Mask and Anesthetic Management in Hamadryas Baboons (Papio hamadryas) Undergoing Laparoscopic Salpingectomy—A Case Series
Scardia, Annalaura;Stabile, Marzia;Acquafredda, Claudia;Lacitignola, Luca;Uva, Annamaria;Crovace, Antonio;Staffieri, Francesco
2023-01-01
Abstract
Simple Summary In this observational study, we aimed to describe the cardiorespiratory variations during laparoscopic abdominal surgery in baboons (Papio hamadryas) anesthetized via a laryngeal mask. Animals were immobilized with a combination of tiletamine/zolazepam and medetomidine. A laryngeal mask was inserted to allow for the delivery of oxygen and isoflurane. Cardiovascular variables showed no alterations, while the respiratory parameters indicated a rise in respiratory rate and end-tidal carbon dioxide concentration during the pneumoperitoneum. Hypercapnia was mild, even with the animal in spontaneous breathing, and it was solved rapidly after the discontinuation of the pneumoperitoneum. The results of this study suggest that laparoscopy can be performed safely in spontaneously breathing baboons. Furthermore, adequate ventilation and gas exchange can be achieved using a laryngeal mask without the need for endotracheal intubation. The study aims to describe the anesthetic and airway management of baboons (Papio hamadryas) undergoing laparoscopic salpingectomy with a laryngeal mask airway (LMA) device. Eleven baboons received tiletamine-zolazepam and medetomidine; anesthesia was induced with propofol. An LMA was positioned for oxygen and isoflurane administration in spontaneous respiration. Heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR), end tidal carbon dioxide (EtCO2), minute volume (MV), and peripheral hemoglobin oxygen saturation (SpO(2)) were recorded before (PREPP) and immediately after abdomen insufflation (PP1), at 10 (PP2), 20 (PP3), and 30 (PP4) minutes during pneumoperitoneum, and after (POSTPP) pneumoperitoneum. The respiratory rate was significantly higher at all times compared to PREPP. The end tidal carbon dioxide concentration was significantly higher at PP2, PP3, PP4, and POSTPP, compared to the previous times. The higher values for RR and EtCO2 were registered at PP4: 22.7 (95% CI 17.6-27.8) breaths/min and 57.9 (95% CI 51.9-63.8) mmHg, respectively. The minute volume was significantly higher at PP4 and POSTPP compared to the other times. The higher value for MV was registered at POSTPP (269.1 (95% CI 206.1-331.8) mL/kg/min). This protocol is suitable for baboons undergoing laparoscopic salpingectomy. The LMA was easy to insert and allowed for good ventilation, gas exchange, and delivery of the anesthetic in spontaneous breathing baboons.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
