Schizophrenia risk is associated with multiple genes. Co-expression is a possible mechanism mediating the orchestrated contribution of these genes to risk. As key regulators of co-expression, miRNAs with a proven involvement in Schizophrenia such as miRNA-137 can be nodes of convergence of risk on the disorder system-level phenotypes. We hypothesized that miRNA-137 target genes converge in a co-expression pathway associated with Schizophrenia risk and that co-expression of these genes is linked with system-level phenotypes previously related with miRNA-137.
Prefrontal Co-Expression of miR-137 Target Genes is Related With Prefrontal Activity During Emotion Recognition
Rampino, Antonio;Pergola, Giulio;Di Carlo, Pasquale;Fazio, Leonardo;Papalino, Marco;Quarto, Tiziana;Romano, Raffaella;Sportelli, Leonardo;Torretta, Silvia;Masellis, Rita;Zunuer, Hailiqiguli;Blasi, Giuseppe;Bertolino, Alessandro
2019-01-01
Abstract
Schizophrenia risk is associated with multiple genes. Co-expression is a possible mechanism mediating the orchestrated contribution of these genes to risk. As key regulators of co-expression, miRNAs with a proven involvement in Schizophrenia such as miRNA-137 can be nodes of convergence of risk on the disorder system-level phenotypes. We hypothesized that miRNA-137 target genes converge in a co-expression pathway associated with Schizophrenia risk and that co-expression of these genes is linked with system-level phenotypes previously related with miRNA-137.File in questo prodotto:
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