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EnglishA label-free single-molecule detection platform based on biofunctionalized organic transistors has been recently proposed. In contrast to state-of-art approaches based on nano-transducers, the aforementioned single-molecule transistor (SiMoT) sensing technology is based on millimeter-sized transistors where the gate is bio-functionalized with about a trillion of antibodies. In this work we provide a detailed investigation of SiMoT biosensors by studying and quantifying the device parameters affected by the biorecognition event. The study combines both measurements and theoretical analyses, showing that a single protein detection taking place at nanometer scale affects a millimeter scale area of the biofunctionalized gate electrode. The dimension of the bioprobe domains affected by the binding is calculated as a function of the nominal protein concentration in the analyte solution. These results provide important insight into the SiMoT biosensor technology, which can guide the development of multi-modal SiMoT detection and integrated SiMoT biosensors arrays.
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| Titolo: | Analysis of Label-Free Single-Molecule Biosensors based on Gate-Biofunctionalized Organic Transistors |
| Autori: | |
| Data di pubblicazione: | 2019 |
| Handle: | http://hdl.handle.net/11586/270953 |
| ISBN: | 978-1-7281-0557-4 |
| Appare nelle tipologie: | 4.1 Contributo in Atti di convegno |
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