Fully substituted triazoles are synthesized by a sustainable direct arylation reaction performed under solvent-free conditions and in the presence of a recyclable Pd/C heterogeneous catalyst. Exclusion of air as well as anhydrous conditions are not required, enabling a convenient synthesis of 1,4,5-trisubstituted 1,2,3-triazoles and 1,2,3-triazole-fused isoindolines starting from 1,4-disubstituted 1,2,3-triazoles, easily prepared via click chemistry, and functionalized aryl iodides.
Direct Arylations via C–H Bond Functionalization of 1,2,3-Triazoles by a Reusable Pd/C Catalyst Under Solvent-Free Conditions
Punzi A.;Zappimbulso N.;Farinola G. M.
2020
Abstract
Fully substituted triazoles are synthesized by a sustainable direct arylation reaction performed under solvent-free conditions and in the presence of a recyclable Pd/C heterogeneous catalyst. Exclusion of air as well as anhydrous conditions are not required, enabling a convenient synthesis of 1,4,5-trisubstituted 1,2,3-triazoles and 1,2,3-triazole-fused isoindolines starting from 1,4-disubstituted 1,2,3-triazoles, easily prepared via click chemistry, and functionalized aryl iodides.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
