Fully substituted triazoles are synthesized by a sustainable direct arylation reaction performed under solvent-free conditions and in the presence of a recyclable Pd/C heterogeneous catalyst. Exclusion of air as well as anhydrous conditions are not required, enabling a convenient synthesis of 1,4,5-trisubstituted 1,2,3-triazoles and 1,2,3-triazole-fused isoindolines starting from 1,4-disubstituted 1,2,3-triazoles, easily prepared via click chemistry, and functionalized aryl iodides.

Direct Arylations via C–H Bond Functionalization of 1,2,3-Triazoles by a Reusable Pd/C Catalyst Under Solvent-Free Conditions

Punzi A.;Zappimbulso N.;Farinola G. M.
2020

Abstract

Fully substituted triazoles are synthesized by a sustainable direct arylation reaction performed under solvent-free conditions and in the presence of a recyclable Pd/C heterogeneous catalyst. Exclusion of air as well as anhydrous conditions are not required, enabling a convenient synthesis of 1,4,5-trisubstituted 1,2,3-triazoles and 1,2,3-triazole-fused isoindolines starting from 1,4-disubstituted 1,2,3-triazoles, easily prepared via click chemistry, and functionalized aryl iodides.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/262264
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