Inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is a multifactorial disorder characterized by chronic inflammation and altered gut barrier function. Dysbiosis, a condition defined by dysregulation of the gut microbiome, has been reported in patients with IBD and in experimental models of colitis. Although several factors have been implicated in directly affecting gut microbial composition, the genetic determinants impacting intestinal dysbiosis in IBD remain relatively unknown.

A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice

De Santis, Stefania;Dicarlo, Manuela;Calasso, Maria;Gigante, Isabella;Lippolis, Antonio;Serino, Grazia;De Angelis, Maria;
2020

Abstract

Inflammatory bowel disease (IBD), including Crohn disease (CD) and ulcerative colitis (UC), is a multifactorial disorder characterized by chronic inflammation and altered gut barrier function. Dysbiosis, a condition defined by dysregulation of the gut microbiome, has been reported in patients with IBD and in experimental models of colitis. Although several factors have been implicated in directly affecting gut microbial composition, the genetic determinants impacting intestinal dysbiosis in IBD remain relatively unknown.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/258796
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