Editorial: Bone: Endocrine target and organ

Bone is essential for mobility, calcium homeostasis, and hematopoietic function. Recently, advances in bone biology have highlighted the importance of skeleton as an endocrine organ (1). In fact, hormones produced by bone cells can control mineral ion homeostasis (i.e., FGF23) and energy balance (i.e., osteocalcin). Naturally, bone is the target organ of different endocrine glands or tissues through numerous hormones and/or molecules as glucagon-like peptide-1 (GLP-1), PTH, adipokines as well as cytokines produced by immune cells. The articles in this topic highlight the effect of molecules released by gut, parathyroids, adipose tissues and immune system on bone remodeling.