Reassortant human group C rotaviruses in Hungary

This is the first study from Europe to report the occurrence of reassortant human RVCs bearing the genetic backbone of the Asian lineage of human RVCs. The introduction of this newly described human RVC lineage in Hungary was accompanied with reassortment involving the NSP4 gene. The question, whether in Europe this lineage is currently co-circulating with the globally common lineage or novel reassortant strains may have replaced the historic RVC lineage over time, is unclear. The apparent changes in the epidemiology of human RVCs is a novel finding that warrants the extension of RVC surveillance using whole genome sequence data in future molecular epidemiological investigations.