Angiogenesis is an important pathway of neoplastic growth and progression. Our several published studies suggest that angiogenesis represents an interspecies pathway of tumour growth due to its roles in several spontaneous canine tumour model. Stromal microenvironment, macrophages and mast cells play a main roles in tumour angiogenesis. Furthermore several recent studies strongly suggest that mast cells density and mast cell activation are correlated with microvascular density. In this context mast cells may stimulates angiogenesis by secretion of their angiogenetic factors such as Vascular Endothelial Growth Factor (VEGF), Tryptase and Chynase. VEGF represents the classical pro-angiogenic factor while Tryptase and Chynase are proteases identified as new pro-angiogenic factor.. Interstingly canine mast cell tumour model (CMCTM) represents a unique model to study the role of mast cells in angiogenetic pathway. CMCTM are classified in well, intermediate and poorly differenziated tumours with and different angiogenetic activity and metastatic capacity. We aim to study by mean of immunohistochemistry and ELISA methods primary mast cell tumour and mast cell tumour lines for the expression of angiogenic factors and mast cell activation. In this context will be possible to evaluate the inhibition of pro-angiogenic factors and mast cell degranulation as a new anti-angiogentic and anti tumour therapy.

Mast cells and angiogenesis: The spontaneous canine mast cell tumour as a model to study the roles of mast cells in tumour angiogenesis

ZIZZO, Nicola;PASSANTINO, Giuseppe;PASSANTINO, Letizia;TINELLI, ANTONELLA;
2011-01-01

Abstract

Angiogenesis is an important pathway of neoplastic growth and progression. Our several published studies suggest that angiogenesis represents an interspecies pathway of tumour growth due to its roles in several spontaneous canine tumour model. Stromal microenvironment, macrophages and mast cells play a main roles in tumour angiogenesis. Furthermore several recent studies strongly suggest that mast cells density and mast cell activation are correlated with microvascular density. In this context mast cells may stimulates angiogenesis by secretion of their angiogenetic factors such as Vascular Endothelial Growth Factor (VEGF), Tryptase and Chynase. VEGF represents the classical pro-angiogenic factor while Tryptase and Chynase are proteases identified as new pro-angiogenic factor.. Interstingly canine mast cell tumour model (CMCTM) represents a unique model to study the role of mast cells in angiogenetic pathway. CMCTM are classified in well, intermediate and poorly differenziated tumours with and different angiogenetic activity and metastatic capacity. We aim to study by mean of immunohistochemistry and ELISA methods primary mast cell tumour and mast cell tumour lines for the expression of angiogenic factors and mast cell activation. In this context will be possible to evaluate the inhibition of pro-angiogenic factors and mast cell degranulation as a new anti-angiogentic and anti tumour therapy.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/148220
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