Objectives: The aim of this study was to assess the accuracy of transvaginal sonography (TVS) in the preoperative staging of endometrial carcinoma, because accurate preoperative staging of the disease would assist in planning the optimal course of treatment. We investigated the ability to distinguish between cases with < 50% and > 50% myometrial invasion (FIGO Stage Ia -Ib vs. Stage Ic), and tumor extension to the cervical stroma (Stage IIb) according to the old FIGO classification. Methods: 140 women with pathologically-proven of endometrial cancer, referred to our istitution between 2007 and 2010, were included in this study. All underwent TVS examination about seven days before the surgical staging. Histological findings of myometrial and cervical stroma invasion were used as the reference standard. Results: The histological subtypes comprised 75% endometrioid adenocarcinoma, 9% serous papillary, 6% endometrioid villoglandular, 4% villoglandular, 3% adenosquamous and 3% clear cells; there were 60% well differentiate, 15% moderately differentiate and 25% poorly differentiate cancers. The sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy for TSV in the evaluation of < 50% myometrial infiltration were 82%,77%, 79%, 80% and 48%; of > 50% myometrial infiltration were 86%, 90%, 86%, 90%, and 57%; for cervical invasion were 80%, 100%, 100%, 89% and 63%, respectively. Conclusion: The transvaginal sonography shows good accuracy in the staging of endometrial carcinoma. Our results support a potential role of TVS for the prediction of strome cervix infiltration of endometrial cancer.

ULTRASOUND PRESURGICAL EVALUATION IN PATIENTS WITH DIAGNOSIS OF ENDOMETRIAL TUMOURS

CORMIO, Gennaro;LOIZZI, VERA;
2011

Abstract

Objectives: The aim of this study was to assess the accuracy of transvaginal sonography (TVS) in the preoperative staging of endometrial carcinoma, because accurate preoperative staging of the disease would assist in planning the optimal course of treatment. We investigated the ability to distinguish between cases with < 50% and > 50% myometrial invasion (FIGO Stage Ia -Ib vs. Stage Ic), and tumor extension to the cervical stroma (Stage IIb) according to the old FIGO classification. Methods: 140 women with pathologically-proven of endometrial cancer, referred to our istitution between 2007 and 2010, were included in this study. All underwent TVS examination about seven days before the surgical staging. Histological findings of myometrial and cervical stroma invasion were used as the reference standard. Results: The histological subtypes comprised 75% endometrioid adenocarcinoma, 9% serous papillary, 6% endometrioid villoglandular, 4% villoglandular, 3% adenosquamous and 3% clear cells; there were 60% well differentiate, 15% moderately differentiate and 25% poorly differentiate cancers. The sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy for TSV in the evaluation of < 50% myometrial infiltration were 82%,77%, 79%, 80% and 48%; of > 50% myometrial infiltration were 86%, 90%, 86%, 90%, and 57%; for cervical invasion were 80%, 100%, 100%, 89% and 63%, respectively. Conclusion: The transvaginal sonography shows good accuracy in the staging of endometrial carcinoma. Our results support a potential role of TVS for the prediction of strome cervix infiltration of endometrial cancer.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/136807
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