Like human herpesvirus 2 (HHV-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs. The antiviral activity of cidofovir was assessed in goats infected experimentally, using various therapeutic protocols. RESULTS: Topic administration of cidofovir 1% cream prevented the onset of virus-induced genital lesions and drastically reduced virus shedding. Cidofovir appears to be a very efficient drug for the prevention of genital lesions caused by an alphaherpesvirus.
Potent inhibition of a genital herpesvirus infection of goats by cidofovir
TEMPESTA, Maria
;CAMERO, Michele;TARSITANO, ELVIRA;CRESCENZO, Giuseppe;MARTELLA, Vito;DECARO, Nicola;ELIA, Gabriella;BUONAVOGLIA, Canio
2007-01-01
Abstract
Like human herpesvirus 2 (HHV-2) in humans, infection by caprine herpesvirus 1 in goats is associated with genital lesions, and this provides a unique model to study the efficacy and effects of anti-herpetic drugs. The antiviral activity of cidofovir was assessed in goats infected experimentally, using various therapeutic protocols. RESULTS: Topic administration of cidofovir 1% cream prevented the onset of virus-induced genital lesions and drastically reduced virus shedding. Cidofovir appears to be a very efficient drug for the prevention of genital lesions caused by an alphaherpesvirus.File in questo prodotto:
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