Background: PPARs are attractive targets of antidiabetic agents. However, PPAR ligands show side effects that hinder their clinical use. Results: LT175 improves insulin sensitivity and reduces body weight via selective gene activation in adipose tissue. Conclusion: LT175 shows an improved pharmacological profile linked to characteristic binding and differential coregulator recruitment. Significance: LT175 may be a scaffold molecule to design a safer generation of PPAR ligands.

LT175 is a novel PPARα/β ligand with potent insulin-sensitizing effects and reduced adipogenic properties

LAGHEZZA, ANTONIO;LOIODICE, Fulvio;
2014

Abstract

Background: PPARs are attractive targets of antidiabetic agents. However, PPAR ligands show side effects that hinder their clinical use. Results: LT175 improves insulin sensitivity and reduces body weight via selective gene activation in adipose tissue. Conclusion: LT175 shows an improved pharmacological profile linked to characteristic binding and differential coregulator recruitment. Significance: LT175 may be a scaffold molecule to design a safer generation of PPAR ligands.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/133309
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