In vitro synergy testing of anidulafungin with fluconazole, tioconazole, 5-flucytosine and amphotericin B against some Candida spp

In this paper the authors investigated a synergistic antimycotic effect between four antifungal drugs Ampho- tericin B, Fluconazole, Tioconazole, and Flucytosine individually combined with Anidulafungin compound. This latter is considered a drug of choice in the treatment of fungal infections; it has good activity both in vitro and in vivo against yeasts and moulds, as Candida and Aspergillus. The goal of this study was to evaluate the in vitro interaction of Anidula- fungin in the synergic combinations with previous reported drugs against 12 Candida strains according to CLSI M27-A3 protocol. A synergistic interaction was observed against the most antifungal strains; in particular an increasing of the an- timycotic efficacy was obtained from the association between Anidulafungin and Amphotericin B or Fluconazole (Mix- ture 4:6). In contrast the association Tioconazole/Anidulafungin was less effective on fungal species growth. The antimy- cotics MIC reduction values were more evident against some strains as C. glabrata, C. krusei, C. tropicalis and C. parap- silosis.