The combined use of Pd(OAc)2, Cu(OAc)2, and dioxygen in molten tetrabutylammonium acetate (TBAA) promotes an unusual cyclopropanation reaction between aryl methyl ketones and styrenes. The process is a dehydrogenative cyclizing coupling that involves a twofold CH activation at the a-position of the ketone. The substrate scope highlights the flexibility of the catalyst; a reaction mechanism is also proposed.

Palladium-Catalyzed Cross-Coupling of Styrenes with Aryl Methyl Ketones in Ionic Liquids: Direct Access to Cyclopropanes

Cotugno P;Monopoli A;CIMINALE, Francesco;MILELLA, ANTONELLA;NACCI, Angelo
2014

Abstract

The combined use of Pd(OAc)2, Cu(OAc)2, and dioxygen in molten tetrabutylammonium acetate (TBAA) promotes an unusual cyclopropanation reaction between aryl methyl ketones and styrenes. The process is a dehydrogenative cyclizing coupling that involves a twofold CH activation at the a-position of the ketone. The substrate scope highlights the flexibility of the catalyst; a reaction mechanism is also proposed.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/132522
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