The antigenic relationships among the original canine parvovirus type 2 (CPV-2) and the variants CPV-2a, - 2b, and - 2c were evaluated. Cross-antigenic evaluation revealed clear differences among the CPV variants, which were more appreciable by serum neutralization (SN) than by hemagglutination inhibition. Antigenic differences were found mostly between the original CPV-2 and the variants, but they were also observed among the variants CPV-2a, - 2b, and - 2c. The variant CPV-2c exhibited a unique antigenic pattern, since it was poorly recognized by the sera of animals immunized with CPV-2, CPV-2a, and CPV-2b. However, animals immunized with CPV-2c exhibited higher SN titers to CPV-2b than to the homologous virus CPV-2c. The observed antigenic differences might drive selection of CPV strains by generating differential immune pressure in the canine population, which raises concerns about vaccine efficacy.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
|Titolo:||Evaluation of the antigenic relationship among the canine parvovirus (CPV-2) variants|
|Data di pubblicazione:||2008|
|Citazione:||Evaluation of the antigenic relationship among the canine parvovirus (CPV-2) variants / Cavalli, A; Martella, V; Desario, C; Camero, M; Bellacicco, A.L; DE PALO, P; Decaro, N; Elia, G; Buonavoglia, C. - In: CLINICAL AND VACCINE IMMUNOLOGY. - ISSN 1556-679X. - 15:3(2008), pp. 534-539.|
|Appare nelle tipologie:||1.1 Articolo in rivista|