A new gene allele of the rotavirus VP4 protein has been identified by sequence analysis of strains detected in the diarrhoeic specimens of young rabbits. The Italian lapine rotavirus (LRV) (160/01, 229/01 and 308/01), identified in 2001, were highly identical (90-95%) among each other, but showed low aa identity (34-77%) to the VP4*-genotype specific sequences of representative rotavirus strains of all remaining P genotypes. One LRV strain (30/96), isolated in 1996, shared the closest amino acid (aa) identity (87-96%) with the P[14] genotype, comprised of human and LRV strains. The new allele of the VP4 gene identified in rabbit rotaviruses was tentatively proposed as genotype P[22]. The potential implications for human health of the emergence of this new allele is discussed in the view of the peculiar characteristics of rotaviruses.

Analisi di rotavirus di coniglio: identificazione di un nuovo genotipo della proteina VP4 / MARTELLA V; CAMARDA A.; TERIO V.; DECARO N.; CAMPOLO M.; MADIO A.; DESARIO C.; MONTRONE S.; TINELLI A.; ELIA G.; BUONAVOGLIA C.. - In: LARGE ANIMALS REVIEW. - ISSN 1124-4593. - 9(2003), pp. 57-62.

Analisi di rotavirus di coniglio: identificazione di un nuovo genotipo della proteina VP4

MARTELLA, Vito;CAMARDA, Antonio;TERIO, VALENTINA;DECARO, Nicola;TINELLI, ANTONELLA;ELIA, Gabriella;BUONAVOGLIA, Canio
2003

Abstract

A new gene allele of the rotavirus VP4 protein has been identified by sequence analysis of strains detected in the diarrhoeic specimens of young rabbits. The Italian lapine rotavirus (LRV) (160/01, 229/01 and 308/01), identified in 2001, were highly identical (90-95%) among each other, but showed low aa identity (34-77%) to the VP4*-genotype specific sequences of representative rotavirus strains of all remaining P genotypes. One LRV strain (30/96), isolated in 1996, shared the closest amino acid (aa) identity (87-96%) with the P[14] genotype, comprised of human and LRV strains. The new allele of the VP4 gene identified in rabbit rotaviruses was tentatively proposed as genotype P[22]. The potential implications for human health of the emergence of this new allele is discussed in the view of the peculiar characteristics of rotaviruses.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/119207
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