A simple, convergent synthesis of the N-carbonyloxy β-d-glucuronide of mexiletine (sodium salt) in moderate yield is described. The compound is now available as an authentic reference standard for analytical studies, enabling more detailed investigation on the metabolism of mexiletine.
First synthesis and full characterization of mexiletine N-carbonyloxy beta-D-glucuronide
CAVALLUZZI, MARIA MADDALENA;LENTINI, Giovanni;CATALANO, ALESSIA;CAROCCI, ALESSIA;FRANCHINI, Carlo
2010-01-01
Abstract
A simple, convergent synthesis of the N-carbonyloxy β-d-glucuronide of mexiletine (sodium salt) in moderate yield is described. The compound is now available as an authentic reference standard for analytical studies, enabling more detailed investigation on the metabolism of mexiletine.File in questo prodotto:
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