The occurrence of gastroenteritis in pups in the first week after canine parvovirus (CPV) vaccination is a frequent finding in the practice, so that a direct association of the onset of clinical signs to the vaccine administration could be hypothesised due to the postulated reversion to virulence of the vaccine strain. In order to investigate the causes responsible for the occurrence of severe enteric symptoms shortly after CPV vaccination, 29 faecal samples collected in years 2004-2006 from dogs displaying post-vaccination gastroenteritis were analysed. The novel molecular tools based on minor groove binder probe technology for discrimination between vaccine and field strains of CPV-2 detected field strains in 18 specimens, with 3 samples showing the co-presence of the vaccine strain administered. Additional 8 samples tested positive for other canine pathogens of the alimentary tract, whereas the remaining 3 samples were found to contain the vaccine strain without evidence of CPV-2 field strains or other pathogens. The present study shows that the occurrence of gastroenteritis shortly after CPV vaccination is mostly caused by field strains of CPV-2 or other pathogens of dogs rather than by a reversion to virulence of the virus contained in CPV vaccines.

The diagnostic dilemma related to the onset of gastroenteritis in pups after canine parvovirus vaccination [Gastroenterite in cuccioli dopo la vaccinazione per la parvovirosi del cane: un dilemma diagnostico]

DECARO, Nicola;ELIA, Gabriella;DESARIO, COSTANTINA;CAMPOLO, MARCO;CAVALLI, Alessandra;MARI, VIVIANA;MARTELLA, Vito;BUONAVOGLIA, Canio
2007

Abstract

The occurrence of gastroenteritis in pups in the first week after canine parvovirus (CPV) vaccination is a frequent finding in the practice, so that a direct association of the onset of clinical signs to the vaccine administration could be hypothesised due to the postulated reversion to virulence of the vaccine strain. In order to investigate the causes responsible for the occurrence of severe enteric symptoms shortly after CPV vaccination, 29 faecal samples collected in years 2004-2006 from dogs displaying post-vaccination gastroenteritis were analysed. The novel molecular tools based on minor groove binder probe technology for discrimination between vaccine and field strains of CPV-2 detected field strains in 18 specimens, with 3 samples showing the co-presence of the vaccine strain administered. Additional 8 samples tested positive for other canine pathogens of the alimentary tract, whereas the remaining 3 samples were found to contain the vaccine strain without evidence of CPV-2 field strains or other pathogens. The present study shows that the occurrence of gastroenteritis shortly after CPV vaccination is mostly caused by field strains of CPV-2 or other pathogens of dogs rather than by a reversion to virulence of the virus contained in CPV vaccines.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11586/116189
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