IRIS
DE BELLIS, MICHELA
 Distribuzione geografica
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Continente #
NA - Nord America 5.057
AS - Asia 1.602
EU - Europa 1.167
SA - Sud America 470
AF - Africa 47
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 1
Totale 8.354
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Nazione #
US - Stati Uniti d'America 4.988
SG - Singapore 666
CN - Cina 473
BR - Brasile 409
IT - Italia 244
SE - Svezia 217
HK - Hong Kong 206
RU - Federazione Russa 180
DE - Germania 110
UA - Ucraina 94
FI - Finlandia 88
VN - Vietnam 85
GB - Regno Unito 82
FR - Francia 53
CA - Canada 38
IN - India 38
ID - Indonesia 32
CI - Costa d'Avorio 25
MX - Messico 24
AR - Argentina 22
JP - Giappone 20
BE - Belgio 18
BD - Bangladesh 16
AT - Austria 14
NL - Olanda 14
IE - Irlanda 12
TR - Turchia 12
ES - Italia 11
EC - Ecuador 10
PL - Polonia 10
IR - Iran 9
VE - Venezuela 9
AU - Australia 8
IQ - Iraq 7
CZ - Repubblica Ceca 6
MA - Marocco 6
PK - Pakistan 6
ZA - Sudafrica 6
AE - Emirati Arabi Uniti 5
PY - Paraguay 5
CL - Cile 4
KR - Corea 4
LT - Lituania 4
OM - Oman 4
CO - Colombia 3
IL - Israele 3
KE - Kenya 3
PE - Perù 3
UY - Uruguay 3
BO - Bolivia 2
CR - Costa Rica 2
DZ - Algeria 2
JM - Giamaica 2
NZ - Nuova Zelanda 2
PA - Panama 2
PH - Filippine 2
RS - Serbia 2
SA - Arabia Saudita 2
SN - Senegal 2
UZ - Uzbekistan 2
AL - Albania 1
AM - Armenia 1
AZ - Azerbaigian 1
BH - Bahrain 1
CH - Svizzera 1
EE - Estonia 1
EG - Egitto 1
EU - Europa 1
GR - Grecia 1
HR - Croazia 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
MM - Myanmar 1
MY - Malesia 1
NG - Nigeria 1
NO - Norvegia 1
NP - Nepal 1
RO - Romania 1
SK - Slovacchia (Repubblica Slovacca) 1
SV - El Salvador 1
TN - Tunisia 1
Totale 8.354
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Città #
Dallas 664
Fairfield 500
Ashburn 457
Woodbridge 386
Chandler 351
Singapore 323
Houston 273
Cambridge 229
Jacksonville 216
Hong Kong 204
Wilmington 198
Seattle 197
Nyköping 186
Ann Arbor 185
Beijing 117
Los Angeles 95
Bari 74
Nanjing 72
New York 70
Roxbury 67
Lawrence 64
Des Moines 44
Bitetto 38
Princeton 38
Boardman 34
Inglewood 33
São Paulo 33
Brooklyn 30
Bitonto 28
Ho Chi Minh City 27
Santa Clara 27
Jakarta 26
San Diego 25
Abidjan 24
Dearborn 24
Hebei 23
Nanchang 21
Chicago 20
Dong Ket 20
Helsinki 19
London 19
Brussels 18
Jiaxing 17
Munich 17
Brasília 15
Shenyang 15
Buffalo 14
Changsha 13
Hanoi 13
Milan 13
Rio de Janeiro 13
Toronto 13
Frankfurt am Main 12
Guangzhou 12
Hefei 11
Montreal 11
Redwood City 11
San Francisco 11
Tokyo 11
Dublin 10
Nuremberg 10
Turku 10
Columbus 9
Falkenstein 9
Mexico City 9
Tianjin 9
Warsaw 9
Belo Horizonte 8
Jinan 8
Stockholm 8
The Dalles 8
Atlanta 7
Falls Church 7
Kunming 7
Porto Alegre 7
Rome 7
San Mateo 7
Washington 7
Brno 6
Charlotte 6
Denver 6
Fortaleza 6
Melbourne 6
Moscow 6
Ningbo 6
North Bergen 6
Pune 6
Wuhan 6
Amsterdam 5
Boston 5
Campinas 5
Chennai 5
Goiânia 5
Johannesburg 5
Monmouth Junction 5
Mumbai 5
Phoenix 5
Poplar 5
Shanghai 5
Taranto 5
Totale 5.997
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Nome #
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 259
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 216
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 206
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 197
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 189
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 186
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 181
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 177
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 170
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 169
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 162
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 161
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 161
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 161
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 158
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 150
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 137
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 135
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 134
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 126
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 124
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 121
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 120
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 118
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 118
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 115
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels 111
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 111
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 108
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 107
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 106
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 105
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 104
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 103
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 100
Effects of GH secretagogues on resting chloride conductance of aged rat skeletal muscle 99
β‐Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation 99
Antitumorali 98
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 96
Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity 89
null 87
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 86
Large screening of newly synthesized Mexiletine and Tocanide analogs as potent use-dependent blockers of skeletal muscle sodium channels: identification of the structural requirements for improving antimyotonic activity 85
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 85
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 84
Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia 80
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 79
Taurine administration to exercised mdx mouse ameliorates fore limb strength and electrophysiological properties of diaphragm and extensor digitorum longus muscles 79
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 79
Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice 79
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy 78
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 78
High affinity block of skeletal muscle sodium channels by newly synthesized analogs of tocainide and its proline-like derivatives 78
null 78
Incresed rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the miotonic activity in vivo 76
null 76
Evaluation of the dual action of new derivatives of mexiletine as use-dependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 75
Potent and stereoselective use-dependent block of skeletal muscle Na+ channels by a new proline-like tocainide derivative 74
null 72
New molecular requirements of Toc derivatives bearing a novel class of Nav1.4 blockers 71
Modification of resting chloride conductance during and after recovery from hindlimb unloading 70
null 70
null 70
Blockers of Skeletal Muscle Nav1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back. 69
Isosteric derivatives of mexiletine: new potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 68
null 68
Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 67
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 67
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 67
Statin‐induced myopathy: Translational studies from preclinical to clinical evidence 66
Evaluation of the dual action of new derivatives of mexiletine as usedependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 65
Molecolar determinants in Mexiletine and Tocainide structure to improve therapy of miotonia 64
LARGE SCREENING OF NEWLY SYNTHESIZED MEXILETINE AND TOCANIDE ANALOGS AS POTENT USE-DEPENDENT BLOCKERS OF SKELETAL MUSCLE SODIUM CHANNELS: IDENTIFICATION OF THE STRUCTURAL REQUIREMENTS FOR IMPROVING ANTIMYOTONIC ACTIVITY 62
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents 61
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 56
N‑Aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels 56
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ. 55
Stereospecific synthesis of “para-hydroxymexiletine“ amd sodium channel blocking activity evaluation 52
Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by n-benzyl analogs of tocainide-like compounds 51
Pharmacological activity of major metabolites of mexiletine on skeletal muscle sodium currents 50
null 49
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 41
Inhibition of skeletal muscle sodium currents by Mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile 41
Toward precision medicine in myotonic syndromes 33
Towards development of Nav1.7 channel modulators for pain treatment: A comparison of mexiletine effect in two cell models by automated patch clamp 18
Adverse effects of antiseizure medications: a review of the impact of pharmacogenetics and drugs interactions in clinical practice 16
Insights into the Activities and Usefulness of Deoxynojirimycin and Morus alba: A Comprehensive Review 11
Totale 8.629
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Categoria #
all - tutte 34.347
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 34.347
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021568 0 0 0 0 0 46 78 46 77 166 99 56
2021/2022548 14 65 5 19 16 42 25 25 51 50 87 149
2022/2023916 116 102 57 81 93 143 6 112 140 5 31 30
2023/2024332 23 54 22 32 31 79 16 12 4 17 11 31
2024/20251.527 65 48 97 49 71 148 173 147 105 71 203 350
2025/20262.143 474 173 778 326 346 46 0 0 0 0 0 0
Totale 8.629