IRIS
DE BELLIS, MICHELA
 Distribuzione geografica
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Continente #
NA - Nord America 3.795
EU - Europa 725
AS - Asia 549
SA - Sud America 20
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 1
Totale 5.095
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Nazione #
US - Stati Uniti d'America 3.784
CN - Cina 344
SE - Svezia 217
IT - Italia 151
SG - Singapore 149
UA - Ucraina 91
FI - Finlandia 74
DE - Germania 62
GB - Regno Unito 53
FR - Francia 28
VN - Vietnam 20
BE - Belgio 17
BR - Brasile 17
CA - Canada 11
IE - Irlanda 11
IN - India 11
JP - Giappone 9
CZ - Repubblica Ceca 6
NL - Olanda 5
HK - Hong Kong 4
AU - Australia 3
ES - Italia 3
ID - Indonesia 3
IR - Iran 3
RU - Federazione Russa 3
CL - Cile 2
NZ - Nuova Zelanda 2
TR - Turchia 2
AR - Argentina 1
BD - Bangladesh 1
CH - Svizzera 1
EE - Estonia 1
EU - Europa 1
KR - Corea 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
LT - Lituania 1
RO - Romania 1
Totale 5.095
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Città #
Fairfield 500
Woodbridge 385
Chandler 357
Ashburn 286
Houston 270
Cambridge 227
Jacksonville 216
Wilmington 197
Nyköping 193
Seattle 193
Ann Arbor 185
Singapore 105
Nanjing 72
Roxbury 67
Lawrence 66
Bari 65
New York 55
Los Angeles 50
Beijing 46
Des Moines 44
Princeton 40
Boardman 34
Inglewood 33
San Diego 25
Dearborn 24
Hebei 23
Nanchang 21
Dong Ket 20
Brussels 17
Jiaxing 17
Santa Clara 17
Helsinki 15
Shenyang 15
Brooklyn 14
Changsha 13
London 13
Milan 13
Guangzhou 11
Hefei 11
Redwood City 11
Dublin 10
Tianjin 9
Jinan 8
Falls Church 7
Kunming 7
San Mateo 7
Brno 6
Ningbo 6
Pune 6
Toronto 6
Wuhan 6
Monmouth Junction 5
San Francisco 5
Taranto 5
Zhengzhou 5
Chongqing 4
Rome 4
Shanghai 4
Trani 4
Clichy 3
Fuzhou 3
Leawood 3
Marseille 3
Montignoso 3
Montreal 3
Munich 3
Nagareyama 3
Paris 3
Santa Marinella 3
Tokyo 3
Washington 3
Wuxi 3
Adelfia 2
Altamura 2
Ardabil 2
Augusta 2
Baotou 2
Brasília 2
Brescia 2
Campobello Di Mazara 2
Chicago 2
Chiswick 2
Clifton 2
Fremont 2
Hangzhou 2
Hong Kong 2
Hounslow 2
Hyderabad 2
Kilburn 2
Madrid 2
Mcallen 2
Melbourne 2
Nulvi 2
Prescot 2
Santiago 2
Sennori 2
Seveso 2
Acton 1
Amsterdam 1
Auckland 1
Totale 4.172
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Nome #
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 141
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 134
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 129
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 128
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 124
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 118
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 117
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 116
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 114
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 113
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 113
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 108
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 108
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 104
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 103
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 103
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 101
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 95
null 90
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 89
null 87
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels 85
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 83
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 79
null 77
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 76
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 76
null 75
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 73
null 72
null 70
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 70
null 69
null 68
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 66
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 66
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 65
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 65
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 64
Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity 62
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 61
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 59
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 57
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 57
Antitumorali 57
null 56
Large screening of newly synthesized Mexiletine and Tocanide analogs as potent use-dependent blockers of skeletal muscle sodium channels: identification of the structural requirements for improving antimyotonic activity 55
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 55
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 54
Effects of GH secretagogues on resting chloride conductance of aged rat skeletal muscle 54
Taurine administration to exercised mdx mouse ameliorates fore limb strength and electrophysiological properties of diaphragm and extensor digitorum longus muscles 54
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 53
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 51
null 49
Modification of resting chloride conductance during and after recovery from hindlimb unloading 46
Potent and stereoselective use-dependent block of skeletal muscle Na+ channels by a new proline-like tocainide derivative 46
High affinity block of skeletal muscle sodium channels by newly synthesized analogs of tocainide and its proline-like derivatives 44
Evaluation of the dual action of new derivatives of mexiletine as usedependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 43
New molecular requirements of Toc derivatives bearing a novel class of Nav1.4 blockers 41
Incresed rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the miotonic activity in vivo 41
Molecolar determinants in Mexiletine and Tocainide structure to improve therapy of miotonia 38
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 38
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 38
β‐Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation 37
Evaluation of the dual action of new derivatives of mexiletine as use-dependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 33
Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 32
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 29
Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice 29
LARGE SCREENING OF NEWLY SYNTHESIZED MEXILETINE AND TOCANIDE ANALOGS AS POTENT USE-DEPENDENT BLOCKERS OF SKELETAL MUSCLE SODIUM CHANNELS: IDENTIFICATION OF THE STRUCTURAL REQUIREMENTS FOR IMPROVING ANTIMYOTONIC ACTIVITY 28
Isosteric derivatives of mexiletine: new potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 26
Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by n-benzyl analogs of tocainide-like compounds 26
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 25
Pharmacological activity of major metabolites of mexiletine on skeletal muscle sodium currents 24
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 24
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 23
Inhibition of skeletal muscle sodium currents by Mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile 18
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ. 18
Statin‐induced myopathy: Translational studies from preclinical to clinical evidence 17
Blockers of Skeletal Muscle Nav1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back. 16
Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia 16
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 16
Stereospecific synthesis of “para-hydroxymexiletine“ amd sodium channel blocking activity evaluation 15
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy 14
N‑Aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels 14
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents 9
Toward precision medicine in myotonic syndromes 3
Totale 5.335
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Categoria #
all - tutte 23.440
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 23.440
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020728 0 0 0 0 0 100 166 126 142 65 101 28
2020/2021971 107 37 80 105 74 46 78 46 77 166 99 56
2021/2022548 14 65 5 19 16 42 25 25 51 50 87 149
2022/2023937 120 105 59 83 95 146 6 115 142 5 31 30
2023/2024339 23 55 22 33 31 83 16 12 4 18 11 31
2024/2025348 66 49 99 49 72 13 0 0 0 0 0 0
Totale 5.335