IRIS
DE BELLIS, MICHELA
 Distribuzione geografica
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Continente #
NA - Nord America 3.801
EU - Europa 796
AS - Asia 574
SA - Sud America 29
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 1
Totale 5.206
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Nazione #
US - Stati Uniti d'America 3.790
CN - Cina 350
SE - Svezia 217
SG - Singapore 162
IT - Italia 152
UA - Ucraina 91
FI - Finlandia 75
RU - Federazione Russa 68
DE - Germania 65
GB - Regno Unito 53
FR - Francia 28
BR - Brasile 24
VN - Vietnam 20
BE - Belgio 17
IN - India 12
CA - Canada 11
IE - Irlanda 11
JP - Giappone 9
CZ - Repubblica Ceca 6
HK - Hong Kong 6
NL - Olanda 5
AU - Australia 3
ES - Italia 3
ID - Indonesia 3
IR - Iran 3
CL - Cile 2
NZ - Nuova Zelanda 2
TR - Turchia 2
AR - Argentina 1
AT - Austria 1
BD - Bangladesh 1
CH - Svizzera 1
EC - Ecuador 1
EE - Estonia 1
EU - Europa 1
KG - Kirghizistan 1
KR - Corea 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
LT - Lituania 1
PK - Pakistan 1
RO - Romania 1
UY - Uruguay 1
UZ - Uzbekistan 1
Totale 5.206
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Città #
Fairfield 500
Woodbridge 385
Chandler 357
Ashburn 286
Houston 270
Cambridge 227
Jacksonville 216
Wilmington 197
Nyköping 193
Seattle 193
Ann Arbor 185
Singapore 117
Nanjing 72
Roxbury 67
Bari 66
Lawrence 66
New York 55
Los Angeles 51
Beijing 46
Des Moines 44
Princeton 40
Boardman 34
Inglewood 33
San Diego 25
Dearborn 24
Hebei 23
Nanchang 21
Dong Ket 20
Brussels 17
Jiaxing 17
Santa Clara 17
Helsinki 16
Shenyang 15
Brooklyn 14
Changsha 13
London 13
Milan 13
Guangzhou 11
Hefei 11
Redwood City 11
Dublin 10
Tianjin 9
Jinan 8
Falls Church 7
Kunming 7
San Mateo 7
Brno 6
Ningbo 6
Pune 6
Toronto 6
Wuhan 6
Monmouth Junction 5
San Francisco 5
Shanghai 5
Taranto 5
Zhengzhou 5
Chongqing 4
Hong Kong 4
Rome 4
Trani 4
Clichy 3
Fuzhou 3
Leawood 3
Marseille 3
Montignoso 3
Montreal 3
Munich 3
Nagareyama 3
Paris 3
Santa Marinella 3
Tokyo 3
Washington 3
Wuxi 3
Adelfia 2
Altamura 2
Ardabil 2
Augusta 2
Baotou 2
Brasília 2
Brescia 2
Campobello Di Mazara 2
Chengdu 2
Chicago 2
Chiswick 2
Clifton 2
Fremont 2
Hangzhou 2
Hounslow 2
Hyderabad 2
Kilburn 2
Madrid 2
Mcallen 2
Melbourne 2
Nulvi 2
Nuremberg 2
Prescot 2
Santiago 2
Sennori 2
Seveso 2
São Paulo 2
Totale 4.193
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Nome #
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 142
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 136
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 133
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 129
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 126
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 122
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 121
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 120
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 118
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 116
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 115
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 110
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 110
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 106
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 106
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 104
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 102
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 95
null 91
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 90
null 87
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels 86
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 84
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 80
null 78
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 77
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 77
null 76
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 74
null 72
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 72
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 71
null 70
null 70
null 68
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 68
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 67
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 66
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 66
Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity 63
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 61
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 61
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 58
Antitumorali 58
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 57
Large screening of newly synthesized Mexiletine and Tocanide analogs as potent use-dependent blockers of skeletal muscle sodium channels: identification of the structural requirements for improving antimyotonic activity 56
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 56
null 56
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 55
Effects of GH secretagogues on resting chloride conductance of aged rat skeletal muscle 55
Taurine administration to exercised mdx mouse ameliorates fore limb strength and electrophysiological properties of diaphragm and extensor digitorum longus muscles 55
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 54
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 51
null 49
Modification of resting chloride conductance during and after recovery from hindlimb unloading 47
Potent and stereoselective use-dependent block of skeletal muscle Na+ channels by a new proline-like tocainide derivative 47
High affinity block of skeletal muscle sodium channels by newly synthesized analogs of tocainide and its proline-like derivatives 46
Evaluation of the dual action of new derivatives of mexiletine as usedependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 44
New molecular requirements of Toc derivatives bearing a novel class of Nav1.4 blockers 42
Incresed rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the miotonic activity in vivo 42
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 41
Molecolar determinants in Mexiletine and Tocainide structure to improve therapy of miotonia 39
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 39
β‐Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation 39
Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice 36
Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 33
Evaluation of the dual action of new derivatives of mexiletine as use-dependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 33
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 30
LARGE SCREENING OF NEWLY SYNTHESIZED MEXILETINE AND TOCANIDE ANALOGS AS POTENT USE-DEPENDENT BLOCKERS OF SKELETAL MUSCLE SODIUM CHANNELS: IDENTIFICATION OF THE STRUCTURAL REQUIREMENTS FOR IMPROVING ANTIMYOTONIC ACTIVITY 29
Isosteric derivatives of mexiletine: new potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 27
Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by n-benzyl analogs of tocainide-like compounds 27
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 26
Pharmacological activity of major metabolites of mexiletine on skeletal muscle sodium currents 25
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 25
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 24
Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia 22
Blockers of Skeletal Muscle Nav1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back. 20
Statin‐induced myopathy: Translational studies from preclinical to clinical evidence 20
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ. 19
Inhibition of skeletal muscle sodium currents by Mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile 18
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy 17
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 17
Stereospecific synthesis of “para-hydroxymexiletine“ amd sodium channel blocking activity evaluation 16
N‑Aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels 15
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents 10
Toward precision medicine in myotonic syndromes 3
Totale 5.464
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Categoria #
all - tutte 24.014
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.014
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020728 0 0 0 0 0 100 166 126 142 65 101 28
2020/2021971 107 37 80 105 74 46 78 46 77 166 99 56
2021/2022548 14 65 5 19 16 42 25 25 51 50 87 149
2022/2023937 120 105 59 83 95 146 6 115 142 5 31 30
2023/2024339 23 55 22 33 31 83 16 12 4 18 11 31
2024/2025477 66 49 99 49 72 142 0 0 0 0 0 0
Totale 5.464