IRIS
DE BELLIS, MICHELA
 Distribuzione geografica
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Continente #
NA - Nord America 5.966
AS - Asia 2.087
EU - Europa 1.710
SA - Sud America 587
Continente sconosciuto - Info sul continente non disponibili 280
AF - Africa 91
OC - Oceania 11
Totale 10.732
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Nazione #
US - Stati Uniti d'America 5.836
SG - Singapore 819
IT - Italia 607
CN - Cina 530
BR - Brasile 462
HK - Hong Kong 222
SE - Svezia 219
RU - Federazione Russa 185
VN - Vietnam 136
DE - Germania 127
FI - Finlandia 125
FR - Francia 120
UA - Ucraina 101
GB - Regno Unito 94
BD - Bangladesh 89
IN - India 67
CA - Canada 65
ID - Indonesia 43
MX - Messico 38
AR - Argentina 37
JP - Giappone 27
CI - Costa d'Avorio 26
NL - Olanda 25
EC - Ecuador 22
TR - Turchia 22
BE - Belgio 18
CO - Colombia 18
IQ - Iraq 17
AT - Austria 16
VE - Venezuela 16
ZA - Sudafrica 16
ES - Italia 14
IE - Irlanda 14
PK - Pakistan 13
CL - Cile 11
KE - Kenya 11
MA - Marocco 11
MY - Malesia 11
PL - Polonia 11
CR - Costa Rica 10
SA - Arabia Saudita 10
AU - Australia 9
IR - Iran 9
PH - Filippine 9
PY - Paraguay 8
AE - Emirati Arabi Uniti 7
UZ - Uzbekistan 7
CZ - Repubblica Ceca 6
DZ - Algeria 6
IL - Israele 6
HN - Honduras 5
KR - Corea 5
LT - Lituania 5
PE - Perù 5
EG - Egitto 4
NP - Nepal 4
OM - Oman 4
PA - Panama 4
UY - Uruguay 4
AL - Albania 3
BO - Bolivia 3
ET - Etiopia 3
GR - Grecia 3
JM - Giamaica 3
JO - Giordania 3
LB - Libano 3
PS - Palestinian Territory 3
TH - Thailandia 3
TN - Tunisia 3
AO - Angola 2
AZ - Azerbaigian 2
CH - Svizzera 2
EE - Estonia 2
HR - Croazia 2
HU - Ungheria 2
KG - Kirghizistan 2
KZ - Kazakistan 2
LK - Sri Lanka 2
NG - Nigeria 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
RO - Romania 2
RS - Serbia 2
SI - Slovenia 2
SN - Senegal 2
SV - El Salvador 2
TW - Taiwan 2
AM - Armenia 1
BF - Burkina Faso 1
BH - Bahrain 1
BT - Bhutan 1
CY - Cipro 1
EU - Europa 1
GM - Gambi 1
LA - Repubblica Popolare Democratica del Laos 1
LY - Libia 1
MM - Myanmar 1
MN - Mongolia 1
NO - Norvegia 1
PT - Portogallo 1
Totale 10.447
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Città #
Dallas 671
Ashburn 529
Fairfield 500
Singapore 416
Woodbridge 386
Chandler 351
San Jose 274
Houston 273
Cambridge 231
Hong Kong 220
Jacksonville 219
Seattle 198
Wilmington 198
Nyköping 186
Ann Arbor 185
Milan 173
Beijing 130
Los Angeles 110
Council Bluffs 109
New York 89
Bari 87
Nanjing 72
Roxbury 67
Lawrence 64
Lauterbourg 61
Rome 57
Helsinki 56
Santa Clara 46
Des Moines 45
Ho Chi Minh City 42
São Paulo 40
Bitetto 38
Princeton 38
Boardman 35
Brooklyn 33
Inglewood 33
Bitonto 28
Jakarta 28
Abidjan 25
Dearborn 25
San Diego 25
Chicago 23
Hebei 23
Buffalo 21
Hanoi 21
Nanchang 21
Dong Ket 20
Frankfurt am Main 20
London 20
Montreal 20
Columbus 19
Brussels 18
Rio de Janeiro 18
Jiaxing 17
Munich 17
Tokyo 17
Toronto 17
Brasília 16
Figino 16
Shenyang 15
Mexico City 14
Changsha 13
The Dalles 13
Falkenstein 12
Guangzhou 12
Orem 12
Atlanta 11
Dublin 11
Hefei 11
Nuremberg 11
Redwood City 11
San Francisco 11
Turin 10
Turku 10
Nairobi 9
Tianjin 9
Warsaw 9
Belo Horizonte 8
Groningen 8
Guayaquil 8
Jinan 8
Johannesburg 8
Kuala Lumpur 8
North Bergen 8
Santiago 8
Stockholm 8
Washington 8
Chennai 7
Denver 7
Falls Church 7
Kunming 7
Phoenix 7
Porto Alegre 7
San Mateo 7
Taranto 7
Amsterdam 6
Baghdad 6
Bogotá 6
Boston 6
Brno 6
Totale 7.107
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Nome #
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 297
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 258
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 252
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 250
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 238
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 237
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 235
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 208
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 205
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 204
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 204
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 199
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 197
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 193
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 177
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 169
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 165
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 161
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 161
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 158
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 156
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 155
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 154
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 150
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 148
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 137
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 137
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 136
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 135
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 128
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 127
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels 126
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy 124
Antitumorali 124
β‐Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation 124
Effects of GH secretagogues on resting chloride conductance of aged rat skeletal muscle 121
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 120
Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia 118
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 118
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 118
Statin‐induced myopathy: Translational studies from preclinical to clinical evidence 116
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 115
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 114
Large screening of newly synthesized Mexiletine and Tocanide analogs as potent use-dependent blockers of skeletal muscle sodium channels: identification of the structural requirements for improving antimyotonic activity 111
Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity 109
Blockers of Skeletal Muscle Nav1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back. 107
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 107
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 104
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 102
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 101
Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice 99
Incresed rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the miotonic activity in vivo 95
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 94
Taurine administration to exercised mdx mouse ameliorates fore limb strength and electrophysiological properties of diaphragm and extensor digitorum longus muscles 94
New molecular requirements of Toc derivatives bearing a novel class of Nav1.4 blockers 92
Potent and stereoselective use-dependent block of skeletal muscle Na+ channels by a new proline-like tocainide derivative 92
Modification of resting chloride conductance during and after recovery from hindlimb unloading 90
Evaluation of the dual action of new derivatives of mexiletine as use-dependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 89
High affinity block of skeletal muscle sodium channels by newly synthesized analogs of tocainide and its proline-like derivatives 88
Evaluation of the dual action of new derivatives of mexiletine as usedependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 87
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Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 87
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 85
Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 83
N‑Aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels 82
Isosteric derivatives of mexiletine: new potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 80
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Molecolar determinants in Mexiletine and Tocainide structure to improve therapy of miotonia 77
LARGE SCREENING OF NEWLY SYNTHESIZED MEXILETINE AND TOCANIDE ANALOGS AS POTENT USE-DEPENDENT BLOCKERS OF SKELETAL MUSCLE SODIUM CHANNELS: IDENTIFICATION OF THE STRUCTURAL REQUIREMENTS FOR IMPROVING ANTIMYOTONIC ACTIVITY 77
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ. 77
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Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents 75
Stereospecific synthesis of “para-hydroxymexiletine“ amd sodium channel blocking activity evaluation 73
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Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 69
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Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by n-benzyl analogs of tocainide-like compounds 68
Pharmacological activity of major metabolites of mexiletine on skeletal muscle sodium currents 66
Insights into the Activities and Usefulness of Deoxynojirimycin and Morus alba: A Comprehensive Review 66
Inhibition of skeletal muscle sodium currents by Mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile 61
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 53
null 49
Toward precision medicine in myotonic syndromes 40
Adverse effects of antiseizure medications: a review of the impact of pharmacogenetics and drugs interactions in clinical practice 37
Towards development of Nav1.7 channel modulators for pain treatment: A comparison of mexiletine effect in two cell models by automated patch clamp 33
Novel insights into the effects of JMV2894, a growth hormone secretagogue, in Duchenne muscular dystrophy: A preclinical study in the D2-mdx mouse model. 21
Branched-chain amino acid supplementation in a mouse model of ageing: Effects on age-related kidney fibrosis 12
Diaphragm‐specific effects of L‐citrulline in mdx mice highlight its potential as adjuvant of standard therapy in Duchenne muscular dystrophy 7
Investigating the Benefit-Risk Profile of Drugs: From Spontaneous Reporting Systems to Real-World Data for Pharmacovigilance 3
Totale 10.732
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Categoria #
all - tutte 40.993
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.993
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022469 0 0 5 19 16 42 25 25 51 50 87 149
2022/2023916 116 102 57 81 93 143 6 112 140 5 31 30
2023/2024332 23 54 22 32 31 79 16 12 4 17 11 31
2024/20251.527 65 48 97 49 71 148 173 147 105 71 203 350
2025/20263.870 474 173 778 326 346 157 368 93 337 331 120 367
2026/2027376 120 158 98 0 0 0 0 0 0 0 0 0
Totale 10.732