IRIS
DE BELLIS, MICHELA
 Distribuzione geografica
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Continente #
NA - Nord America 5.515
AS - Asia 2.008
EU - Europa 1.367
SA - Sud America 567
AF - Africa 89
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 1
Totale 9.558
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Nazione #
US - Stati Uniti d'America 5.418
SG - Singapore 805
CN - Cina 516
BR - Brasile 455
IT - Italia 270
HK - Hong Kong 219
SE - Svezia 219
RU - Federazione Russa 185
VN - Vietnam 135
DE - Germania 127
FI - Finlandia 125
FR - Francia 118
UA - Ucraina 100
GB - Regno Unito 94
IN - India 67
CA - Canada 51
BD - Bangladesh 47
ID - Indonesia 43
AR - Argentina 33
MX - Messico 33
CI - Costa d'Avorio 26
JP - Giappone 26
NL - Olanda 25
TR - Turchia 22
EC - Ecuador 20
BE - Belgio 18
IQ - Iraq 17
AT - Austria 16
ZA - Sudafrica 16
CO - Colombia 14
VE - Venezuela 14
ES - Italia 13
IE - Irlanda 13
PK - Pakistan 13
KE - Kenya 11
MA - Marocco 11
CL - Cile 10
PL - Polonia 10
SA - Arabia Saudita 10
AU - Australia 9
IR - Iran 9
MY - Malesia 9
PH - Filippine 9
PY - Paraguay 8
AE - Emirati Arabi Uniti 7
UZ - Uzbekistan 7
CZ - Repubblica Ceca 6
DZ - Algeria 6
IL - Israele 6
CR - Costa Rica 5
KR - Corea 5
LT - Lituania 5
PE - Perù 5
EG - Egitto 4
NP - Nepal 4
OM - Oman 4
UY - Uruguay 4
AL - Albania 3
BO - Bolivia 3
ET - Etiopia 3
GR - Grecia 3
JO - Giordania 3
LB - Libano 3
PA - Panama 3
PS - Palestinian Territory 3
TN - Tunisia 3
AO - Angola 2
AZ - Azerbaigian 2
CH - Svizzera 2
EE - Estonia 2
HR - Croazia 2
HU - Ungheria 2
JM - Giamaica 2
KG - Kirghizistan 2
KZ - Kazakistan 2
LK - Sri Lanka 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
RO - Romania 2
RS - Serbia 2
SI - Slovenia 2
SN - Senegal 2
TW - Taiwan 2
AM - Armenia 1
BH - Bahrain 1
BT - Bhutan 1
CY - Cipro 1
EU - Europa 1
GM - Gambi 1
HN - Honduras 1
LA - Repubblica Popolare Democratica del Laos 1
LY - Libia 1
MM - Myanmar 1
MN - Mongolia 1
NI - Nicaragua 1
NO - Norvegia 1
PT - Portogallo 1
QA - Qatar 1
SK - Slovacchia (Repubblica Slovacca) 1
SR - Suriname 1
Totale 9.555
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Città #
Dallas 666
Ashburn 505
Fairfield 500
Singapore 409
Woodbridge 386
Chandler 351
Houston 273
Cambridge 229
Hong Kong 217
Jacksonville 216
San Jose 214
Seattle 198
Wilmington 198
Nyköping 186
Ann Arbor 185
Beijing 124
Los Angeles 98
Bari 78
New York 74
Nanjing 72
Roxbury 67
Lawrence 64
Lauterbourg 61
Helsinki 56
Des Moines 44
Ho Chi Minh City 41
São Paulo 40
Bitetto 38
Princeton 38
Council Bluffs 35
Boardman 34
Inglewood 33
Brooklyn 31
Santa Clara 30
Bitonto 28
Jakarta 28
Abidjan 25
San Diego 25
Dearborn 24
Hebei 23
Hanoi 21
Nanchang 21
Chicago 20
Dong Ket 20
Frankfurt am Main 20
London 20
Brussels 18
Jiaxing 17
Montreal 17
Munich 17
Rio de Janeiro 17
Tokyo 16
Brasília 15
Buffalo 15
Shenyang 15
Toronto 15
Milan 14
Changsha 13
Falkenstein 12
Guangzhou 12
Orem 12
Dublin 11
Hefei 11
Mexico City 11
Nuremberg 11
Redwood City 11
San Francisco 11
Turku 10
Atlanta 9
Columbus 9
Nairobi 9
Rome 9
Tianjin 9
Warsaw 9
Belo Horizonte 8
Groningen 8
Jinan 8
Johannesburg 8
North Bergen 8
Stockholm 8
The Dalles 8
Chennai 7
Denver 7
Falls Church 7
Guayaquil 7
Kunming 7
Porto Alegre 7
San Mateo 7
Santiago 7
Washington 7
Amsterdam 6
Baghdad 6
Brno 6
Charlotte 6
Fortaleza 6
Haiphong 6
Istanbul 6
Kuala Lumpur 6
Melbourne 6
Moscow 6
Totale 6.600
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Nome #
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 286
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 240
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 234
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 226
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 225
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 216
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 215
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 196
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 191
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 188
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 187
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 185
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 184
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 181
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 172
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 163
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 152
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 149
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 148
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 146
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 145
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 144
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 141
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 135
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 132
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 132
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 131
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 126
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 123
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 122
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 119
β‐Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation 118
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels 117
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 114
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 113
Antitumorali 113
Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia 110
Effects of GH secretagogues on resting chloride conductance of aged rat skeletal muscle 110
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 109
Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity 106
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 106
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy 103
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 103
Large screening of newly synthesized Mexiletine and Tocanide analogs as potent use-dependent blockers of skeletal muscle sodium channels: identification of the structural requirements for improving antimyotonic activity 98
Statin‐induced myopathy: Translational studies from preclinical to clinical evidence 98
Blockers of Skeletal Muscle Nav1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back. 97
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 96
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 96
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 94
Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice 92
Incresed rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the miotonic activity in vivo 87
null 87
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 86
Evaluation of the dual action of new derivatives of mexiletine as usedependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 85
Evaluation of the dual action of new derivatives of mexiletine as use-dependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 84
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 83
Potent and stereoselective use-dependent block of skeletal muscle Na+ channels by a new proline-like tocainide derivative 82
Taurine administration to exercised mdx mouse ameliorates fore limb strength and electrophysiological properties of diaphragm and extensor digitorum longus muscles 82
High affinity block of skeletal muscle sodium channels by newly synthesized analogs of tocainide and its proline-like derivatives 80
Modification of resting chloride conductance during and after recovery from hindlimb unloading 78
null 78
New molecular requirements of Toc derivatives bearing a novel class of Nav1.4 blockers 76
Isosteric derivatives of mexiletine: new potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 76
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 76
null 76
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 75
N‑Aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels 74
null 72
Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 71
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents 70
null 70
null 70
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ. 70
Molecolar determinants in Mexiletine and Tocainide structure to improve therapy of miotonia 69
null 68
LARGE SCREENING OF NEWLY SYNTHESIZED MEXILETINE AND TOCANIDE ANALOGS AS POTENT USE-DEPENDENT BLOCKERS OF SKELETAL MUSCLE SODIUM CHANNELS: IDENTIFICATION OF THE STRUCTURAL REQUIREMENTS FOR IMPROVING ANTIMYOTONIC ACTIVITY 67
Stereospecific synthesis of “para-hydroxymexiletine“ amd sodium channel blocking activity evaluation 63
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 61
Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by n-benzyl analogs of tocainide-like compounds 58
Pharmacological activity of major metabolites of mexiletine on skeletal muscle sodium currents 56
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 49
null 49
Inhibition of skeletal muscle sodium currents by Mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile 49
Toward precision medicine in myotonic syndromes 38
Adverse effects of antiseizure medications: a review of the impact of pharmacogenetics and drugs interactions in clinical practice 32
Towards development of Nav1.7 channel modulators for pain treatment: A comparison of mexiletine effect in two cell models by automated patch clamp 31
Insights into the Activities and Usefulness of Deoxynojirimycin and Morus alba: A Comprehensive Review 24
Novel insights into the effects of JMV2894, a growth hormone secretagogue, in Duchenne muscular dystrophy: A preclinical study in the D2-mdx mouse model. 5
Investigating the Benefit-Risk Profile of Drugs: From Spontaneous Reporting Systems to Real-World Data for Pharmacovigilance 1
Totale 9.835
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Categoria #
all - tutte 36.758
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 36.758
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021321 0 0 0 0 0 0 0 0 0 166 99 56
2021/2022548 14 65 5 19 16 42 25 25 51 50 87 149
2022/2023916 116 102 57 81 93 143 6 112 140 5 31 30
2023/2024332 23 54 22 32 31 79 16 12 4 17 11 31
2024/20251.527 65 48 97 49 71 148 173 147 105 71 203 350
2025/20263.349 474 173 778 326 346 157 368 93 337 297 0 0
Totale 9.835