IRIS
DE BELLIS, MICHELA
 Distribuzione geografica
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Continente #
NA - Nord America 5.745
AS - Asia 2.066
EU - Europa 1.692
SA - Sud America 577
AF - Africa 89
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 1
Totale 10.181
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Nazione #
US - Stati Uniti d'America 5.630
SG - Singapore 817
IT - Italia 593
CN - Cina 526
BR - Brasile 458
HK - Hong Kong 221
SE - Svezia 219
RU - Federazione Russa 185
VN - Vietnam 135
DE - Germania 127
FI - Finlandia 125
FR - Francia 118
UA - Ucraina 101
GB - Regno Unito 94
BD - Bangladesh 79
IN - India 67
CA - Canada 62
ID - Indonesia 43
AR - Argentina 36
MX - Messico 36
JP - Giappone 27
CI - Costa d'Avorio 26
NL - Olanda 25
TR - Turchia 22
EC - Ecuador 20
BE - Belgio 18
IQ - Iraq 17
AT - Austria 16
CO - Colombia 16
ZA - Sudafrica 16
VE - Venezuela 15
ES - Italia 14
IE - Irlanda 13
PK - Pakistan 13
CL - Cile 11
KE - Kenya 11
MA - Marocco 11
PL - Polonia 10
SA - Arabia Saudita 10
AU - Australia 9
IR - Iran 9
MY - Malesia 9
PH - Filippine 9
PY - Paraguay 8
AE - Emirati Arabi Uniti 7
UZ - Uzbekistan 7
CR - Costa Rica 6
CZ - Repubblica Ceca 6
DZ - Algeria 6
IL - Israele 6
KR - Corea 5
LT - Lituania 5
PE - Perù 5
EG - Egitto 4
NP - Nepal 4
OM - Oman 4
UY - Uruguay 4
AL - Albania 3
BO - Bolivia 3
ET - Etiopia 3
GR - Grecia 3
JM - Giamaica 3
JO - Giordania 3
LB - Libano 3
PA - Panama 3
PS - Palestinian Territory 3
TN - Tunisia 3
AO - Angola 2
AZ - Azerbaigian 2
CH - Svizzera 2
EE - Estonia 2
HR - Croazia 2
HU - Ungheria 2
KG - Kirghizistan 2
KZ - Kazakistan 2
LK - Sri Lanka 2
NG - Nigeria 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
RO - Romania 2
RS - Serbia 2
SI - Slovenia 2
SN - Senegal 2
SV - El Salvador 2
TH - Thailandia 2
TW - Taiwan 2
AM - Armenia 1
BH - Bahrain 1
BT - Bhutan 1
CY - Cipro 1
EU - Europa 1
GM - Gambi 1
HN - Honduras 1
LA - Repubblica Popolare Democratica del Laos 1
LY - Libia 1
MM - Myanmar 1
MN - Mongolia 1
NO - Norvegia 1
PT - Portogallo 1
QA - Qatar 1
Totale 10.178
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Città #
Dallas 669
Ashburn 521
Fairfield 500
Singapore 414
Woodbridge 386
Chandler 351
Houston 273
San Jose 238
Cambridge 229
Hong Kong 219
Jacksonville 218
Seattle 198
Wilmington 198
Nyköping 186
Ann Arbor 185
Milan 172
Beijing 128
Los Angeles 105
Bari 87
New York 85
Nanjing 72
Roxbury 67
Lawrence 64
Lauterbourg 61
Helsinki 56
Rome 56
Des Moines 44
Ho Chi Minh City 41
São Paulo 40
Bitetto 38
Princeton 38
Santa Clara 38
Boardman 35
Council Bluffs 35
Inglewood 33
Brooklyn 32
Bitonto 28
Jakarta 28
Abidjan 25
San Diego 25
Dearborn 24
Hebei 23
Chicago 21
Hanoi 21
Nanchang 21
Dong Ket 20
Frankfurt am Main 20
London 20
Montreal 20
Buffalo 19
Columbus 19
Brussels 18
Jiaxing 17
Munich 17
Rio de Janeiro 17
Tokyo 17
Toronto 17
Figino 16
Brasília 15
Shenyang 15
Changsha 13
Mexico City 13
The Dalles 13
Falkenstein 12
Guangzhou 12
Orem 12
Atlanta 11
Dublin 11
Hefei 11
Nuremberg 11
Redwood City 11
San Francisco 11
Turin 10
Turku 10
Nairobi 9
Tianjin 9
Warsaw 9
Belo Horizonte 8
Groningen 8
Jinan 8
Johannesburg 8
North Bergen 8
Santiago 8
Stockholm 8
Washington 8
Chennai 7
Denver 7
Falls Church 7
Guayaquil 7
Kunming 7
Porto Alegre 7
San Mateo 7
Taranto 7
Amsterdam 6
Baghdad 6
Brno 6
Charlotte 6
Fortaleza 6
Haiphong 6
Istanbul 6
Totale 6.945
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Nome #
Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies 290
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 249
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 246
A long-term treatment with taurine prevents cardiac dysfunction in mdx mice 243
Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, α-methyl prednisolone. 236
Contractile efficiency of dystrophic mdx mouse muscle: In vivo and ex vivo assessment of adaptation to exercise of functional end points 231
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy 231
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 206
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 202
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 201
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 200
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 197
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. 194
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 189
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 174
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 169
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 161
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 155
Ergogenic effect of bcaas and l-alanine supplementation: Proof-of-concept study in a murine model of physiological exercise 155
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading 155
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 153
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 151
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 148
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 147
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 145
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 135
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 134
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 134
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 133
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 126
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 125
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels 124
β‐Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation 122
Antitumorali 120
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy 119
Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle 119
Effects of GH secretagogues on resting chloride conductance of aged rat skeletal muscle 118
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 117
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 115
Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia 114
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 112
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 111
Statin‐induced myopathy: Translational studies from preclinical to clinical evidence 110
Large screening of newly synthesized Mexiletine and Tocanide analogs as potent use-dependent blockers of skeletal muscle sodium channels: identification of the structural requirements for improving antimyotonic activity 108
Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity 108
Blockers of Skeletal Muscle Nav1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back. 104
Protein Kinase C-Theta Controls the CLC-1 Chloride Channel Function and Skeletal Muscle Phenotype: A Biophysical and Gene Expression Study in Pkc-Theta Null Mice 104
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 102
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 100
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 97
Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice 97
Potent and stereoselective use-dependent block muscle Na+ channels by a new proline-like tocainide derivative 92
Incresed rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the miotonic activity in vivo 92
Taurine administration to exercised mdx mouse ameliorates fore limb strength and electrophysiological properties of diaphragm and extensor digitorum longus muscles 89
Potent and stereoselective use-dependent block of skeletal muscle Na+ channels by a new proline-like tocainide derivative 88
Evaluation of the dual action of new derivatives of mexiletine as usedependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 87
Evaluation of the dual action of new derivatives of mexiletine as use-dependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 87
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Modification of resting chloride conductance during and after recovery from hindlimb unloading 85
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 84
New molecular requirements of Toc derivatives bearing a novel class of Nav1.4 blockers 83
Modifications of ion channel activity and expression in soleus muscle fibers account for hypogravity-induced functional alterations 83
High affinity block of skeletal muscle sodium channels by newly synthesized analogs of tocainide and its proline-like derivatives 82
Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 80
N‑Aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels 80
Isosteric derivatives of mexiletine: new potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 79
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LARGE SCREENING OF NEWLY SYNTHESIZED MEXILETINE AND TOCANIDE ANALOGS AS POTENT USE-DEPENDENT BLOCKERS OF SKELETAL MUSCLE SODIUM CHANNELS: IDENTIFICATION OF THE STRUCTURAL REQUIREMENTS FOR IMPROVING ANTIMYOTONIC ACTIVITY 76
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Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ. 74
Molecolar determinants in Mexiletine and Tocainide structure to improve therapy of miotonia 73
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents 73
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Stereospecific synthesis of “para-hydroxymexiletine“ amd sodium channel blocking activity evaluation 70
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Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by n-benzyl analogs of tocainide-like compounds 67
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 63
Pharmacological activity of major metabolites of mexiletine on skeletal muscle sodium currents 62
Insights into the Activities and Usefulness of Deoxynojirimycin and Morus alba: A Comprehensive Review 61
Inhibition of skeletal muscle sodium currents by Mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile 59
Molecular spatial geometry of CLC-K ligands: optimal requirements towards high affinity channel block 50
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Toward precision medicine in myotonic syndromes 40
Adverse effects of antiseizure medications: a review of the impact of pharmacogenetics and drugs interactions in clinical practice 35
Towards development of Nav1.7 channel modulators for pain treatment: A comparison of mexiletine effect in two cell models by automated patch clamp 33
Novel insights into the effects of JMV2894, a growth hormone secretagogue, in Duchenne muscular dystrophy: A preclinical study in the D2-mdx mouse model. 16
Diaphragm‐specific effects of L‐citrulline in mdx mice highlight its potential as adjuvant of standard therapy in Duchenne muscular dystrophy 5
Branched-chain amino acid supplementation in a mouse model of ageing: Effects on age-related kidney fibrosis 4
Investigating the Benefit-Risk Profile of Drugs: From Spontaneous Reporting Systems to Real-World Data for Pharmacovigilance 2
Totale 10.460
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Categoria #
all - tutte 39.776
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 39.776
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022548 14 65 5 19 16 42 25 25 51 50 87 149
2022/2023916 116 102 57 81 93 143 6 112 140 5 31 30
2023/2024332 23 54 22 32 31 79 16 12 4 17 11 31
2024/20251.527 65 48 97 49 71 148 173 147 105 71 203 350
2025/20263.870 474 173 778 326 346 157 368 93 337 331 120 367
2026/2027104 104 0 0 0 0 0 0 0 0 0 0 0
Totale 10.460