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Mostrati risultati da 41 a 60 di 114
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An integrated methodology to interface structure- and ligand-based drug design 1-gen-2008 Giangreco, I; Nicolotti, Orazio; Miscioscia, Tf; Tedeschi, P; Carotti, A; Leonetti, Francesco; Carotti, A.
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1-gen-2008 Stefanachi, Angela; Nicolotti, Orazio; Leonetti, Francesco; Cellamare, Saverio; Campagna, Francesco; Loza, Mi; Brea, Jm; Mazza, F; Gavuzzo, E; Carotti, Angelo
A new approach to combine ligand- and structure-based drug design. 1-gen-2008 Nicolotti, Orazio; Miscioscia, Tf; Carotti, A; Leonetti, Francesco; Giangreco, I; Carotti, A.
A multitarget approach in cancer research 1-gen-2009 Leonetti, Francesco; Stefanachi, Angela; Pellegrino, G; Nicolotti, Orazio; Catto, Marco; Muncipinto, G; Carotti, A.
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 1-gen-2009 Leonetti, Francesco; Stefanachi, Angela; Pellegrino, G; Nicolotti, Orazio; Catto, Marco; Muncipinto, G; Carotti, A.
A Multi-Objective Optimization Algorithm for Molecular Design 1-gen-2009 Giangreco, I; Nicolotti, Orazio; Miscioscia, T. F.; Convertino, M; Mangiatordi, G. F.; Siragusa, L; Catto, Marco; Leonetti, Francesco; Stefanachi, Angela; Carotti, A.
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 1-gen-2009 Pisani, Leonardo; Muncipinto, G; Miscioscia, Tf; Nicolotti, Orazio; Leonetti, Francesco; Catto, Marco; Caccia, C; Salvati, P; SOTO OTERO, R; MENDEZ ALVAREZ, E; Passeleu, C; Carotti, A.
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 1-gen-2009 Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Leonetti, Francesco; Stefanachi, Angela; Carotti, A.
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 1-gen-2009 Stolfa, A; Cellamare, Saverio; Stefanachi, Angela; Catto, Marco; Leonetti, Francesco; Nicolotti, Orazio; Carotti, A.
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 1-gen-2009 Carotti, A; Leonetti, Francesco; Catto, Marco; Stefanachi, Angela; Nicolotti, Orazio
Solid phase synthesis of potential PKs inhibitors 1-gen-2009 Pellegrino, G; Leonetti, Francesco; Nicolotti, Orazio; Catto, Marco; Stefanachi, Angela; Pisani, Leonardo; Carotti, A.
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 1-gen-2009 Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Leonetti, Francesco; Stefanachi, Angela; Carotti, A.
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 1-gen-2010 Nicolotti, Orazio; Giangreco, I; Miscioscia, Tf; Convertino, M; Leonetti, Francesco; Pisani, Leonardo; Carotti, Angelo
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 1-gen-2010 Nicolotti, Orazio; Giangreco, I; Pisani, Leonardo; Catto, Marco; Leonetti, Francesco; Stefanachi, Angela; Cellamare, Saverio; Carotti, A.
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 1-gen-2010 Leonetti, Francesco; Muncipinto, G; Stefanachi, Angela; Pellegrino, G; Nicolotti, Orazio; Catto, Marco; Cellamare, Saverio; Pisani, Leonardo; Carotti, A.
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 1-gen-2010 Pisani, Leonardo; Catto, Marco; Giangreco, I; Leonetti, Francesco; Nicolotti, Orazio; Stefanachi, Angela; Cellamare, Saverio; Carotti, Angelo
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 1-gen-2010 Pellegrino, G; Leonetti, F; Carotti, Angelo; Nicolotti, Orazio; Pisani, Leonardo; Stefanachi, Angela; Catto, Marco
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 1-gen-2011 Giangreco, I; Lattanzi, Gianluca; Nicolotti, Orazio; Catto, Marco; Laghezza, Antonio; Leonetti, Francesco; Stefanachi, Angela; Carotti, Angelo
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 1-gen-2011 CONEJO GARCÍA, A; Pisani, Leonardo; DEL CARMEN NÚÑEZ, M; Catto, Marco; Nicolotti, Orazio; Leonetti, Francesco; Campos, J; Gallo, M; Espinosa, A; Carotti, Angelo
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 1-gen-2011 Pisani, Leonardo; Catto, Marco; Leonetti, Francesco; Nicolotti, Orazio; Stefanachi, Angela; Campagna, Francesco; Carotti, Angelo
Mostrati risultati da 41 a 60 di 114
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