An Easy access to Unsymmetrically Substituted 4,4’-bi-1,2,3-Triazole

A convenient synthesis of 4-alkynyl-1,2,3-triazoles and novel unsymmetrically substituted 4,40-bi-1,2,3- triazole derivatives has been devised starting from easily available 1-trimethylsilyl-1,3-butadiyne. The starting compound was reacted with several azides, leading to 4-(silylalkynyl)-1,2,3-triazoles, which were easily transformed into 4-arylalkynyl-1,2,3-triazoles by a Pd catalyzed coupling reaction with aryl halides, or into novel 4,40-bi-1,2,3-triazole derivatives by a subsequent cyclization reaction with azides.