Simultaneous determination of opiates, methadone, cocaine and metabolites, cannabinoids in hair using GC-MS

Aventaggiato, Lucia; Gagliano Candela, R.

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A procedure is presented for simultaneous analysis of morphine, codeine, 6-monoacethylmorphine, methadone, cocaine, benzoylecgonine, ecgonine methylesther, cocaethylene, tetrahydrocannabinol, cannabidiol, and cannabinol, in hair, of drug of abuse, addicts. The method involves, decontamination in sodium dodecyl sulfate 1%, distilled water and methanol, pulverization in a ball mill,addition of deuterated internals standards, heat extraction in methanol. The extracts were evaporated to dryness and analyzed with gas/chromatography/mass spectrometry(GC/MS) before and after BSTFA/TMCS 1% silylation. The extracts were analyzed using electron impact GC/MS operating in SIM mode.

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Titolo:	Simultaneous determination of opiates, methadone, cocaine and metabolites, cannabinoids in hair using GC-MS
Autori:	AVENTAGGIATO, Lucia GAGLIANO CANDELA R. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2005
Rivista:	BIOCHIMICA CLINICA
Abstract:	A procedure is presented for simultaneous analysis of morphine, codeine, 6-monoacethylmorphine, methadone, cocaine, benzoylecgonine, ecgonine methylesther, cocaethylene, tetrahydrocannabinol, cannabidiol, and cannabinol, in hair, of drug of abuse, addicts. The method involves, decontamination in sodium dodecyl sulfate 1%, distilled water and methanol, pulverization in a ball mill,addition of deuterated internals standards, heat extraction in methanol. The extracts were evaporated to dryness and analyzed with gas/chromatography/mass spectrometry(GC/MS) before and after BSTFA/TMCS 1% silylation. The extracts were analyzed using electron impact GC/MS operating in SIM mode.
Handle:	http://hdl.handle.net/11586/9754
Appare nelle tipologie:	1.5 Abstract in rivista

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