Iatrogenic calcinosis cutis in a child affected by Lymphoblastic Acute Leukemia.

Iatrogenic calcinosis cutis is a rare disorder that can be due to the intravenous administration of calcium or phosphate-containing infusions such as calcium gluconate or calcium chloride with extravasation. Fortunately, the course of calci- nosis cutis is benign in immunocompetent child- ren. The treatment remains supportive therapy. After about 6 months, there is no evidence of tissue calcification. We describe a 4-year-old girl with Acute Lymphoblastic Leukemia (ALL) who developed severe calcinosis cutis in the left humerus after extravasation of calcium glu- conate during the treatment for the tumor-lysis- syndrome-related hypocalcaemia. Surgical de- bridement and local wound care were not suc- cessful, and so a temporary suspension of che- motherapy was necessary to achieve complete healing of the lesion. Notwithstanding this com- plication, her ALL is in complete hematological remission after 8 months from the diagnosis. No functional or sensitive impairment due to the cutis has persisted.