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EnglishThe liver is an estrogen-responsive organ and the administration of estrogens in humans increases the hepatic synthesis of many proteins. The existence of a circadian rhythm of estrogen receptors in the liver has been proved by different authors. We studied the presence of a different responsiveness of the human liver to the estrogens in two groups of post-menopausal women by evaluating the changes in ceruloplasmin serum level. Conjugated equine estrogens were administered at different times (A: 8 a.m. and B: 8 p.m.). The replacement therapy increased ceruloplasmin serum levels both in group A and B, but the increase was higher in group B than in group A. These data reflect indirectly the presence of a circadian rhythm of hepatic responsiveness to the estrogens.
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| Titolo: | Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times. |
| Autori: | |
| Data di pubblicazione: | 1992 |
| Rivista: | |
| Citazione: | Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times. / Clemente C; Russo F; Caruso MG; Giangrande M; Fanizza G; Di Leo A. - In: HORMONE AND METABOLIC RESEARCH. - ISSN 0018-5043. - 24:4(1992), pp. 191-193. |
| Abstract: | The liver is an estrogen-responsive organ and the administration of estrogens in humans increases the hepatic synthesis of many proteins. The existence of a circadian rhythm of estrogen receptors in the liver has been proved by different authors. We studied the presence of a different responsiveness of the human liver to the estrogens in two groups of post-menopausal women by evaluating the changes in ceruloplasmin serum level. Conjugated equine estrogens were administered at different times (A: 8 a.m. and B: 8 p.m.). The replacement therapy increased ceruloplasmin serum levels both in group A and B, but the increase was higher in group B than in group A. These data reflect indirectly the presence of a circadian rhythm of hepatic responsiveness to the estrogens. |
| Handle: | http://hdl.handle.net/11586/87540 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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