Factors that determine the course of the natural disease caused by CCoV are not well understood. CCoV is responsible for mild or moderate enteritis in dogs. Symptoms may vary, but are more severe in young pups, or in combination with other pathogens. In neonatal dogs the virus appears to replicate primarily in the villus tips of the enterocytes of the small intestine. Production of local antibodies (IgAs) restricts the spread of the virus within the intestine and arrests the progress of infection. A recent study established the common occurrence of both CCoV types I and II in infected dogs. Therefore, failure to isolate CCoV type I in vitro prevents an authentic evaluation of the immunological characteristics of this new genotype of CCoV and hinders the acquisition of key information on its pathogenetic role in dogs.
Coronaviruses in dogs: an epidemiological study
PRATELLI, Annamaria
2008-01-01
Abstract
Factors that determine the course of the natural disease caused by CCoV are not well understood. CCoV is responsible for mild or moderate enteritis in dogs. Symptoms may vary, but are more severe in young pups, or in combination with other pathogens. In neonatal dogs the virus appears to replicate primarily in the villus tips of the enterocytes of the small intestine. Production of local antibodies (IgAs) restricts the spread of the virus within the intestine and arrests the progress of infection. A recent study established the common occurrence of both CCoV types I and II in infected dogs. Therefore, failure to isolate CCoV type I in vitro prevents an authentic evaluation of the immunological characteristics of this new genotype of CCoV and hinders the acquisition of key information on its pathogenetic role in dogs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
