ABSTRACT. Aim of this study was the role of various determinants of urinary levels of t-t muconic acid at low environmental benzene exposure. 224 exposed and 65 non exposed workers were recruited for urinary collection and questionnaire answering related to food consumption. Personal environmental measurements of benzene were also carried out. The medians of benzene environmental determinations were significantly higher among the exposed workers (0,0039 mg/m3 /0,001 mg/m3). The medians of urinary t-t MA were higher in the exposed workers(44 μg/g creatinine / 40 μg/g creatinine). The medians food score of sorbic acid (SA) was slightly higher among the exposed workers (1999-2001). Fruit and cheese consumption produced a significant increase of the estimates of urinary t-t MA associated to the exposure; on the other hand, meat and other foods produced their reduction. A multivariate logistic unconditional well fitted model (LR χ2 = 8.84 p = 0.03) showed the persistence of significant risk [POR =1.95 (1.05-3.64)] of urinary t-t MA for the exposed workers adjusted by alcohol consumption and SA score. In conclusion, we found that benzene metabolism is modulated by food consumption at low concentrations of benzene exposure.
MONITORAGGIO AMBIENTALE E STUDIO DEI DETERMINANTI DELL’AC. T,T MUCONICO NEL MONITORAGGIO BIOLOGICO DI LAVORATORI ESPOSTI A BASSE DOSI DI BENZENE
CASSANO, Filippo;FERRI, Giovanni Maria;
2006-01-01
Abstract
ABSTRACT. Aim of this study was the role of various determinants of urinary levels of t-t muconic acid at low environmental benzene exposure. 224 exposed and 65 non exposed workers were recruited for urinary collection and questionnaire answering related to food consumption. Personal environmental measurements of benzene were also carried out. The medians of benzene environmental determinations were significantly higher among the exposed workers (0,0039 mg/m3 /0,001 mg/m3). The medians of urinary t-t MA were higher in the exposed workers(44 μg/g creatinine / 40 μg/g creatinine). The medians food score of sorbic acid (SA) was slightly higher among the exposed workers (1999-2001). Fruit and cheese consumption produced a significant increase of the estimates of urinary t-t MA associated to the exposure; on the other hand, meat and other foods produced their reduction. A multivariate logistic unconditional well fitted model (LR χ2 = 8.84 p = 0.03) showed the persistence of significant risk [POR =1.95 (1.05-3.64)] of urinary t-t MA for the exposed workers adjusted by alcohol consumption and SA score. In conclusion, we found that benzene metabolism is modulated by food consumption at low concentrations of benzene exposure.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
