CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishIn an attempt to isolate protein kinase A anchoring proteins (AKAPs) involved in vasopressin-mediated water reabsorbtion, the complete sequence of the human AKAP Ht31 was determined and a partial cDNA of its rat orthologue (Rt31) was cloned. The Ht31 cDNA includes the estrogen receptor cofactor Brx and the RhoA GDP/GTP exchange factor protolymphoid blast crisis (Lbc) sequences. The Ht31 gene was assigned to chromosome 15 (region q24-q25). It encodes Ht31 and the smaller splice variants Brx and proto-Lbc. A protein of the predicted size of Ht31 (309 kDa) was detected in human mammary carcinoma and HeLa cells. Anti-Ht31/Rt31 antibodies immunoprecipitated RhoA from primary cultured rat renal inner medullary collecting duct cells, indicating an interaction between the AKAP and RhoA in vivo. These results suggest that Ht31/ Rt31. represent a new type of AKAP, containing both an anchoring and a catalytic domain, which appears to be capable of modulating the activity of an interacting partner. Ht31/Rt31 have the potential to integrate Rho and protein kinase A signaling pathways, and thus, are prime candidates to regulate vasopressin-mediated water reabsorbtion. (C) 2001 Federation of European Biochemical Societies
HT31: THE first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling / KLUSSMANN E; EDEMIR B; PEPPERLE B; TAMMA G; HENN V; KLAUSCHENZ E; HUNDSRUCKER C; MARIC K; ROSENTHAL W. - In: FEBS LETTERS. - ISSN 0014-5793. - 507:3(2001), pp. 264-268.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | HT31: THE first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling | |
| Autori: | ||
| Data di pubblicazione: | 2001 | |
| Rivista: | ||
| Citazione: | HT31: THE first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling / KLUSSMANN E; EDEMIR B; PEPPERLE B; TAMMA G; HENN V; KLAUSCHENZ E; HUNDSRUCKER C; MARIC K; ROSENTHAL W. - In: FEBS LETTERS. - ISSN 0014-5793. - 507:3(2001), pp. 264-268. | |
| Handle: | http://hdl.handle.net/11586/72587 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11586/72587
Copyright © 2021