Normothermic machine perfusion (NMP) has emerged as a preservation strategy for liver grafts, sustaining aerobic metabolism and allowing real-time viability assessment of marginal grafts that would otherwise be discarded1. Despite these advantages, a critical procedural step remains inherited from the cold storage paradigm: after NMP, the liver is commonly recooled with cold preservation solutions before implantation. However, the physiological necessity of this step has never been validated in the context of NMP.
Multicentre parallel-group open-label non-inferiority randomized clinical trial of recooling versus no recooling after normothermic machine perfusion in liver transplantation: ARANMP-LT protocol
Tandoi, FrancescoMembro del Collaboration Group
;Scalera, IreneMembro del Collaboration Group
;
2026-01-01
Abstract
Normothermic machine perfusion (NMP) has emerged as a preservation strategy for liver grafts, sustaining aerobic metabolism and allowing real-time viability assessment of marginal grafts that would otherwise be discarded1. Despite these advantages, a critical procedural step remains inherited from the cold storage paradigm: after NMP, the liver is commonly recooled with cold preservation solutions before implantation. However, the physiological necessity of this step has never been validated in the context of NMP.File in questo prodotto:
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