Leishmaniasis is expanding worldwide along with sand fly vectors. In China, particular challenges arise from its broad climatic and ecological gradients, the diversity of phlebotomine sand fly species, and numerous potential mammalian and reptilian hosts. Two ecological types of visceral leishmaniasis (VL) are recognized: anthroponotic VL (AVL) caused by Leishmania donovani and zoonotic VL (ZVL) caused by Leishmania infantum, which is subdivided into mountain-type (MT-ZVL) where dogs are the main reservoir, and desert-type (DT-ZVL) with uncertain reservoirs. Over the last decade, VL has re-emerged in central and northern regions of China, with increasing MT-ZVL notifications and evidence of canine infections in geographical areas where transmission had not previously been reported. This review synthesizes three decades of literature on canine leishmaniasis (CanL) and its vectors in China, focusing on domestic and wild reservoirs in the maintenance of zoonotic VL. Molecular studies reveal substantial genetic heterogeneity within the L. donovani complex and frequent discordance between single-locus markers (e.g., ITS1, cytb) and higher-resolution approaches (MLST/MLMT). Leishmania infection in dogs is most common in western foci, with high detection rates ranging from 24.8% to 77.2%, especially in Gansu and Sichuan Provinces, where subclinical infections predominate. Also, evidence of co-circulating unclassified Leishmania lineages related to Sauroleishmania complicates diagnosis and surveillance. Vector ecology, including the endophilic/exophilic behavior of Phlebotomus chinensis and the role of P. sichuanensis at high altitudes, overlaps with environmental change, dog management, and increasing stray dog populations, thereby amplifying transmission risk. Based on available data, dog culling is ineffective for long-term control of CanL due to poor diagnostics, rapid replacement of culled dogs, and ecological complexity. Conversely, vector control and bite prevention, using topical pyrethroid repellents (collars, spot-on pipettes) and possibly oral isoxazolines, should be implemented in dogs as control measures after appropriate field evaluation. Key gaps include insufficient canine surveillance and validation of diagnostic tools, as well as incomplete characterization of wildlife reservoirs. Strengthened One Health surveillance, integrating genomics, vector studies, and reservoir investigations, is essential to guide targeted control and predict future spread.
Zoonotic leishmaniasis in China: Current status and challenges to elimination
Barrs V.
;Mendoza-Roldan J. A.;Bezerra-Santos M. A.;Otranto D.
2026-01-01
Abstract
Leishmaniasis is expanding worldwide along with sand fly vectors. In China, particular challenges arise from its broad climatic and ecological gradients, the diversity of phlebotomine sand fly species, and numerous potential mammalian and reptilian hosts. Two ecological types of visceral leishmaniasis (VL) are recognized: anthroponotic VL (AVL) caused by Leishmania donovani and zoonotic VL (ZVL) caused by Leishmania infantum, which is subdivided into mountain-type (MT-ZVL) where dogs are the main reservoir, and desert-type (DT-ZVL) with uncertain reservoirs. Over the last decade, VL has re-emerged in central and northern regions of China, with increasing MT-ZVL notifications and evidence of canine infections in geographical areas where transmission had not previously been reported. This review synthesizes three decades of literature on canine leishmaniasis (CanL) and its vectors in China, focusing on domestic and wild reservoirs in the maintenance of zoonotic VL. Molecular studies reveal substantial genetic heterogeneity within the L. donovani complex and frequent discordance between single-locus markers (e.g., ITS1, cytb) and higher-resolution approaches (MLST/MLMT). Leishmania infection in dogs is most common in western foci, with high detection rates ranging from 24.8% to 77.2%, especially in Gansu and Sichuan Provinces, where subclinical infections predominate. Also, evidence of co-circulating unclassified Leishmania lineages related to Sauroleishmania complicates diagnosis and surveillance. Vector ecology, including the endophilic/exophilic behavior of Phlebotomus chinensis and the role of P. sichuanensis at high altitudes, overlaps with environmental change, dog management, and increasing stray dog populations, thereby amplifying transmission risk. Based on available data, dog culling is ineffective for long-term control of CanL due to poor diagnostics, rapid replacement of culled dogs, and ecological complexity. Conversely, vector control and bite prevention, using topical pyrethroid repellents (collars, spot-on pipettes) and possibly oral isoxazolines, should be implemented in dogs as control measures after appropriate field evaluation. Key gaps include insufficient canine surveillance and validation of diagnostic tools, as well as incomplete characterization of wildlife reservoirs. Strengthened One Health surveillance, integrating genomics, vector studies, and reservoir investigations, is essential to guide targeted control and predict future spread.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
