Letter: Helicobacter pylori and Eosinophilic Oesophagitis-Lost in Definition?

We read with interest the meta-analysis by Spinelli et al. which reported a 46% lower risk of eosinophilic oesophagitis (EoE) and oesophageal eosinophilia in individuals infected with Helicobacter pylori. While we commend the authors for their contributions, the decision to group EoE and oesophageal eosinophilia may have introduced bias, as these entities have dissimilar diagnostic criteria. According to the most recent clinical guideline, EoE can be diagnosed in the setting of symptoms of oesophageal dysfunction that are absent in oesophageal eosinophilia, plus an eosinophil-predominant infiltrate in the oesophagus [...].